Muneer Hasham leads a team that is facilitating research into cancer biology and tumor microenvironments in the context of genetic diversity.
Carol Bult is leading a team that has laid the groundwork for advancements in non-small cell lung cancer research using patient derived xenograft (PDX) mice.
Jennifer Trowbridge and her team reveal the molecular signaling pathway most associated with clonal hematopoiesis and how blocking a specific cell-surface receptor in the pathway can tip the balance toward positive health outcomes.
Kristen Onos is a key player in developing drug testing pipelines to determine outcomes of potential Alzheimer’s disease treatments and preventatives.
Vivek Kumar is using machine learning and computational science to examine frailty in mice to study the biology of aging.
Peter Robinson is working with hospital systems across the U.S. to pool COVID patient data and better define the scope of the long COVID problem and provide better clinical insight for patients.
Guangwen “Gary” Ren's new research shows that the structural cells in the lung (fibroblasts) drive myeloid cell dysfunction to create a more welcoming environment for metastatic cancer.
Many women worldwide are affected by endometriosis, though there has been relatively little research into causes or possible therapies. Elise Courtois, associate director of the Single Cell Biology group at The Jackson Laboratory, is a leading proponent for increasing awareness of and funding for endometriosis.
David Serreze's latest paper, published in the Journal of Immunology, was named a Top Read in the July issue for its findings regarding a protective mechanism against type 1 diabetes in an important mouse model for the disease.
A team led by JAX's Edison Liu and Francesca Menghi used patient data, patient-derived xenograft (PDX) mouse models, and engineered cancer cell lines to investigate why people with BRCA mutations respond better and are less likely to develop platinum-based therapy resistance than patients with BRCA1 promoter methylation.
A research team led by Professor Gareth Howell, Ph.D., and Kate Foley, Ph.D., a former graduate student in his lab, used mice to investigate just how exercise, in this case running, affects many traits associated with Alzheimer’s disease in their brains and their bodies.
JAX Professor Peter Robinson has spearheaded an effort to make phenotypic data (a collection of our traits) accessible and computable across platforms. The result, called the Phenopacket schema, is now freely available.
Roel Verhaak is leading an international group of clinicians and researchers, investigating why gliomas develop resistance and recur after initial therapies.
Ryan Tewhey, Ph.D., is leading efforts to apply high-throughput analyses to understand both how non-coding genome regulation works and its many roles in disease.
Using sophisticated labeling methods, a team led by Professor Karolina Palucka, M.D., Ph.D., and Jan Martinek, Ph.D., analyzed patient samples of metastatic melanoma for further insight into how cancer cells are able to escape immune response and grow elsewhere in the body.
New research from JAX indicates that fibroblasts may hold the ability to jump start human tissue repair and regeneration capabilities.
MODEL-AD is working to develop and make accessible mouse models useful for Alzheimer's disease and dementia research.
A new Jackson Laboratory-Stanford Medicine research project will develop plasma protein ‘clocks’ to measure aging in mice and humans.
JAX Professor Patsy Nishina and her colleagues have developed mouse models for translational vision research that are now available to the wider biomedical research community.
Sleep affects our health in a multitude of ways and JAX researchers are working to figure out how on a genetic level.
Some people carry mutations that would usually predispose them to Alzheimer's disease but instead remain healthy. Now JAX researcher Catherine Kaczorowski is studying this phenomenon and identifying future approaches that may lead to resilience-based therapeutics.
Ron Korstanje at JAX is searching for genetic clues to slowing the progress of end-stage renal disease in patients with Alport syndrome and other kidney diseases.
Duygu Ucar of JAX is teaming up with infectious disease and aging experts to lead a study to understand influenza vaccine responsiveness in older adults.
Catherine Kaczorowski of JAX to launch study of genetic factors involved in sleep disturbances in patients with Alzheimer’s disease and other dementias.
JAX researchers used long-read mRNA sequencing to catalog all mRNAs in primary breast cancer samples and revealed previously undocumented mRNA isoforms that can change protein function and may contribute to cancer progression and therapy response.
Catherine Kaczorowski's new grant will help her study the genetic mechanisms controlling resilience to Huntington's disease.
The V Foundation for Cancer Research has awarded a grant to JAX's Lucas Chang for genetic studies of the immune response to cancer.
Extrachromosomal DNA elements (ecDNAs) are frequently detected in cancer and drive activation of oncogenes (cancer-promoting genes) via increased gene expression.
Researchers are working to broaden the genetic diversity of mice used in biomedical research.
Understanding how we use our brain to make decisions is a daunting task, given our brain's extensive webs of neural wiring and circuitry. Now, JAX researchers are using a surprising tool to investigate goal-directed behaviors: the rabies virus.
Type 2 diabetes, a major health problem throughout much of the world, is being targeted on a genetic level by JAX researchers.
Using advanced mouse populations and newly developed research protocols for measuring proteins, JAX researchers are exploring how proteome is regulated, why it varies on individual genetics, and how consistent this is across different populations.
Jennifer Trowbridge of JAX seeks to thwart the mutations and inflammation that accumulate in aging bone marrow to maintain production of healthy blood cells and reduce blood cancer risk.
Gliomas, malignant brain tumors, are considered incurable by current science. What, then, makes them so adaptable and dangerous? A JAX research team featuring Kevin Johnson, Kevin Anderson, and Roel Verhaak use single-cell genetics to examine how gliomas handle stress so well.
New mouse models are key to designing better therapeutic interventions for people at risk for addiction.
Chia-Lin Wei looked at SARS-CoV-2 RNA genomes and sub-genomic viral RNA in symptomatic and asymptomatic patients and found distinct, consistent differences between the patient groups. The findings have important implications for developing better COVID-19 risk mitigation and clinical strategies.
Mice with different genetic backgrounds exhibit highly variable responses to SARS-CoV-2 infection, mirroring the large differences in COVID-19 disease severity seen in humans.
JAX Professor Robert Burgess, Ph.D., investigates the genetic and molecular mechanisms underlying peripheral nerve degeneration in CMT, and his new findings may advance cutting edge genetic treatments for this and other rare disease.
In a paper published in Cell Reports, a team including JAX assistant professor Travis Hinson, M.D, present a detailed portrait of one of actinin’s interprotein interactions and provide a compendium of proteins that could be the focus of further study.
A team of JAX and Broad Institute researchers, led by Ryan Tewhey, Ph.D., has developed HCR-FlowFISH, a method that provides high throughput characterization of regulatory elements and their complex interactions in nearly any expressed gene and cell system. The researchers investigated nearly 300,000 candidate regulatory locations and provided detailed functional insight for those that affect expression of a family of four specific genes associated with cholesterol levels.
Cancer cells have significant differences from normal cells, and the differences can serve as treatment targets. Recent progress in immuno-oncology, which leverages our own immune systems to kill cancer cells, has provided a powerful new clinical option.
Professor Peter Robinson, M.D., MSc., and Associate Computational Scientist Daniel Danis, Ph.D., used machine learning and datasets of splice variants associated with Mendelian (single-gene, inherited) disorders to develop a new algorithm to develop a new algorithm to improve clinical diagnostics.
A team led by Roel Verhaak analyzed patient cancers before and after radiotherapy and found a deletion signature in many post-treatment samples. The finding indicates that combining radiotherapy with DNA repair inhibition may improve efficacy.
Assistant Professor J. Travis Hinson, M.D., is using the latest cellular technologies to engineer human cells to investigate the molecular mechanisms preventing human heart regeneration.
Coordinated, proper hair cell orientation is vital for both hearing and motion detection, because each cell only detects motion in one direction. But how is that achieved? Basile Tarchini reveals the complex molecular cascade that yields proper hair cell arrangement in a new paper in Nature Communications.
JAX Scientific Director Nadia Rosenthal was featured in a Nature article and podcast about scientists' efforts to solve the mystery of long-haul COVID.
New research done by a JAX researcher suggests that certain cells can act as a biomarker for metastatic melanoma as well as provide a potential therapeutic target to block metastatic spread.
JAX researchers report in Cancer Cell further insight into yet another way extrachromosomal, circular DNA (ecDNA) may promote cancer.
JAX Assistant Professor Olga Anczuków, Ph.D., has shed new light on the role of MYC in regulating alternative RNA splicing, a process in which genes called splicing factors enable a single gene to code for multiple unique proteins, or isoforms.
New research done by JAX scientists investigates how bone marrow affects our health as we age.
JAX researcher Dr. Vivek Kumar trains computers (using machine learning) to analyze specific mouse behaviors.
Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease.
The interaction of SARS-CoV-2, the novel coronavirus causing the global COVID-19 pandemic, and the human immune system has been the focus of intensive research.
Five-year grant funds first study of genetic diversity and function of S. epidermidis strains to reveal a shift from benign to infectious.
A JAX team developed CUP-AI-Dx, a machine learning tool that uses RNA sequence data for analysis. The researchers show that CUP-AI-Dx provides an important clinical tool to help guide therapies for CUP patients.
JAX Professor Sheng Li, Ph.D., presents a tool, epihet, that automates the epigenetic analysis of AML cells. epihet allows researchers to assess epigenetic differences between cells, identify genomic locations where the differences occur, and associate cellular epigenetic profiles with cancer-related biological function.
PDX models provide researchers with the ability to work with tumors directly from patients within a living (in vivo) system, making them a preeminent platform for preclinical cancer research.
A team led by JAX Associate Professor Jeffrey Chuang, Ph.D., has developed image processing and convolutional neural network software that can combine images of cancers from different organs to reveal how they are related to one another.
JAX researchers are developing a valuable new cytokine release syndrome research tool.
Olga Anczukow describes a network of regulation for splicing factors, key proteins for controlling protein production. Dysfunction can cause a variety of diseases, including cancer.
Cancer researchers have identified the enhanced expression of many signaling pathways implicated in cancer initiation and maintenance.
New research reveals significant cellular differences between adult female and male mouse hearts.
A team of JAX scientists led by Tanmoy Bhattacharyya, Ph.D. and Natalie Powers, Ph.D. found that in mice with very low or no PRDM9in some genetic backgrounds are fertile and a protein called CHK2 can act as a modifier promoting redundancy of PRDM9 in mice.
Acute myeloid leukemia (AML) is an aggressive, difficult-to-treat cancer. Nonetheless, researchers have found that there are not as many genetic mutations associated with AML as with most other cancers. Aberrant epigenetic patterning, on the other hand, is emerging as a hallmark of AML.
New JAX research brings significant elements of immunology and neurodegeneration research into play.
JAX researchers are probing the mysteries of pluripotent stem cells; the earliest stages of life.
The quest to find a cure for Alzheimer’s disease (AD) has almost entirely met with failure at the clinical trial stage. Nonetheless, there have been research advances, particularly during the last few years, that are laying the foundation for progress in the years ahead.
New JAX research shows that inhibiting neutrophil lipid accumulation could provide a valuable anti-metastatic therapy target for cancer patients.
National Institute on Aging grant funds annual interdisciplinary science meeting focused on systems immunology of aging at JAX Genomic Medicine.
JAX Associate Professor Greg Cox discovered that mutations in NEMF, a key component of RQC, cause neuromuscular disorders in mice. He also identified human patients with pathogenic variants in NEMF who exhibit both motor neuron dysfunction and intellectual disabilities, underscoring RQC’s clinical importance.
Cross-species analyses identify Dlgap2 as a regulator of age-related cognitive decline and Alzheimer’s dementia.
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
Muneer Hasham is working to improve the odds of success in one of the most difficult drug development areas of all: cancer.
The role(s) that extra-chromosomal DNA (ecDNA) may play in cancer have been the subject of speculation, but details have been elusive. Now, a paper in Nature Genetics implicates ecDNA in a wide variety of cancers, and associates it with aggressive, difficult-to-treat cases.
Genetically varied mouse populations revealing genetic elements contributing to SARS-CoV-2 infection risk.
JAX Professor Jacques Banchereau led a multi-institutional team that profiled more than 360,000 cells from children and adult SLE patients and healthy controls, finding a distinctive interferon gene expression signature across a wide variety of blood cells. The data provides a road map for further exploration and identifies potential targets for therapeutic development.
ChIA-PIPE expands the capabilities of previous analysis pipelines that identified chromatin loops, the DNA sequences of linked DNA, and protein binding peaks within the DNA sequences.
JAX Professor Derya Unutmaz, M.D., led an effort to develop an assay that determines how well anti-SARS-CoV-2 antibodies are able to neutralize binding with ACE-2, the human receptor for the coronavirus.
A new discovery by JAX cancer researcher Sheng Li points to the possibility of new lymphoma treatments that would restore the protective effect of TET2 in tumors where it has been mutated.
A research team led by Albert Cheng developed a new method, CASFx, that leverages CRISPR technology to alter messenger RNA splicing and precisely control protein isoform production.
Jackson Laboratory faculty have secured grant funding that will help train predoctoral students in cutting edge genetic theory and practice in the “Training Program in Precision Genetics of Aging, Alzheimer’s Disease and Related Dementias."
Working with human patient data, a research team led by JAX Associate Professor Greg Carter and summer student Nikhil Milind have identified two distinct subtypes, inflammatory and non-inflammatory, of Alzheimer’s disease. The finding provides important insights for identifying disease biomarkers and therapeutic targets.
To understand microbiome dynamics, it’s important to identify not only which microbial species are present in a given sample, but also to determine their growth rates.
More than 98% of the genome doesn’t code for proteins, but recent findings show that many non-coding sequences play important roles in health and disease.
Human pluripotent stem cells have enormous potential as research tools and as a platform for creating new therapies for intractable medical conditions.
Using a new meta-knowledgebase, cancer researchers have demonstrated improved matching between a patient cohort and variant interpretations of potential clinical significance, from an average of 33% per individual knowledgebase to 57% in aggregate.
Jackson Laboratory professor Dr. Roel Verhaak performed a study of cancer in dogs, looking for symptoms and cause of dog cancerous tumors on dogs, and in doing so, found some surprising connections to cancer in people.
The results of a new PDXNet consortium study provide a key validation toward translating xenograft findings into clinical treatments for cancer patients.
Three-dimensional genomic compartments and sub-compartments help regulate gene expression across the genome. As more data comes out about 3D genomic structures, there is an increasing need to efficiently identify and characterize sub-compartments and their roles in genome function. Sheng Li and her team developed a new computational tool, SCI, that outperforms previously developed algorithms for this purpose.
Commonly used wild-type mouse strains are not optimal for studying infections of the newly discovered coronavirus. Fortunately, a transgenic model at JAX is now available to fill the unmet need for an in vivo experimental platform for COVID-19 research.
New research shows that silencers modify 3D chromatin organizations to suppress the expression of certain genes at certain time points during development. Disruption of the process can lead to developmental disorders and has also been implicated in certain cancers.
JAX Professor Roel Verhaak has thoroughly analyzed sporadic canine gliomas and found that their molecular characteristics, including gene mutations and duplications, resemble those of humans.
A research team led by Duygu Ucar and Jacques Banchereau analyzed immune cells from a large cohort of healthy people spanning the adult life span and found significant differences in immune gene regulation and function between the sexes that increased with age.
To assess how microbial species are derived and their importance, a team led by JAX Assistant Professor Julia Oh took a hard look at the dynamics of strain diversity for a specific bacterium in human skin, Staphylococcus (S.) epidermidis.
In a paper in Genes & Development, Assistant Professor Chris Baker led a team that shows two proteins, PRDM9 and HELLS, form a complex that binds to hot spots and opens the site to the DNA breakage and repair needed for recombination. As “pioneer factors” in the process, both proteins are needed for successful meiosis and fertility.
A research team led by JAX Assistant Professor Basile Tarchini investigates the genetic basis of vestibular organization to understand better what causes dizziness.
Splicing factors, comparable to gene editors in our DNA, could hold the key to treating the worst type of breast cancer.
Cancer cells behave in much the same way as an invasive species on an island, and the efforts to eradicate those species can inform the development of cancer therapies.
JAX Assistant Professor Albert Cheng led a team to develop split selectable markers, a method that can indicate the successful integration of multiple transgenes.
JAX Associate Professor Zhong-wei Zhang explores the effects of abnormal alternative RNA splicing during neurodevelopment, which can lead to increased susceptibility to seizures in adults.
The genome editing tool, Casilio, can be used to efficiently remove methyl groups from DNA and activate expression of methylation-silenced genes in experimental systems. Casilio was created by Jackson Laboratory Assistant Professor Albert Cheng.
This year, science luminaries came to Maine for an additional special symposium that celebrated the McKusick Short Course's 60th anniversary. The symposium title, “The Future of Human and Experimental Genetics,” foreshadowed the theme of the talks.
A research team led by Professor and Janeway Distinguished Chair Robert Braun, Ph.D., and Associate Research Scientist Manju Sharma, Ph.D., found a rare subpopulation of spermatogonial cells expressing a specific protein, EOMES, that appear to represent the elusive long-lived spermatogonial stem cells that support continued spermatogenesis.
Online analysis tool, Protein-RNA Association Strength (PRAS), free for academic researchers.
JAX postdoctoral associate Frederick Varn, Ph.D., has received a prestigious fellowship from the Jane Coffin Childs Memorial Fund for Medical Research.
An interview with 2019 Chen Award winner Li Jin about his goals for the International Human Phenome Consortium and its value to the research community.
JAX postdoctoral associate Kira Young, Ph.D., has received the ASH Scholar Award from the American Society for Hematology to support her research studying “old blood.” Young is using the award to understand the different types of white blood cells that make up the immune system and how they change as we age.
New genetically diverse mouse populations mirror human genetic variation, providing a powerful new experimental platform to complement human data insights, particularly for complex trait and complex disease research.
New research shows that wild-derived mouse strains show human-like variety in Alzheimer’s gene effects.
Scientists have developed an expanded toolkit that enables investigations of cellular traits at the single cell level at an unprecedented level of detail.
Advances in data resource aggregation and analytics will enable the research community to readily identify convergent molecular evidence for novel mechanisms of aging and other health and disease-related processes.
Study: Mice that exercised avoided the kind of damage that in humans has been associated with dementia, stroke and other negative outcomes, despite being fed a western-like diet and gaining significant weight.
There has been an explosion of digital medical data in recent years, taking many forms. Much of the most valuable data—clinical patient data—is currently stored in electronic health record (EHR) systems, providing a theoretical gold mine for large-scale integration and analyses of patient traits, diseases, treatments, progression over time, outcomes and more.
Supported by a recent two-year grant from the National Institutes of Health, JAX researchers are developing a new form of gene intercept methodology to deplete mouse macrophages but not other cells.
A research team led by Nadia Rosenthal, Ph.D., documented large differences in survival, cardiac dilation and scar size among a population of genetically-diverse mice.
A new paper in PNAS offers new insights into the proteins that influence our ability to perceive sound direction and intensity.
Recently developed diversity mouse strains and outbred mouse populations have created research options that parallel or even exceed human genetic diversity.
A recent paper from a team including JAX Professor Se-Jin Lee shows that a signaling pathway once thought to protect heart cells from damage actually promotes breakdown with aging.
A recent Cell paper uses long-read DNA sequencing and other advanced genomics tools and methods to shed light on genomic structural variants.
New research shows that proteins work together to enable DNA double-strand breaks during meiosis.
A complicated three-dimensional network involving proteins and specific DNA sequences helps regulate the expression of genes. New work led by JAX’s Chia-Lin Wei shows how one protein, SOX2, plays a significant role in neural stem cells, affecting many aspects of development and function.
Cancer cells need energy. A lot of it. Their aggressive growth, not surprisingly, is therefore largely fueled by an abnormal metabolism.
A research team led by Basile Tarchini has found two new proteins that are essential to the correct elongation of stereocilia, tiny hair-like cellular protrusions in the inner ear.
A paper published in Molecular Biology of the Cell leads to important implications for both reproductive biology and data science.
Michael L. Stitzel and collaborators thoroughly characterize an important new cell line for type 2 diabetes research.
New research led by Jennifer Trowbridge provides insight into risk factors for clonal hematopoiesis-to-leukemia progression.
A roundup of the latest research news and upcoming courses at The Jackson Laboratory.
Using PDX mouse models, JAX Associate Professor Jeff Chuang has tracked the evolution of triple negative breast cancer cells following administration of common forms of chemotherapy.
A roundup of the latest research news and upcoming courses at The Jackson Laboratory.
JAX researchers find that reducing Hp1bp3 expression mimics age-related cognitive decline through mechanisms reminiscent of aging and Alzheimer's disease
Recently developed outbred mouse populations, such as the diversity outbred (DO) mice at The Jackson Laboratory (JAX), have created research options that parallel or even exceed human genetic diversity. Research with DO mice offers a full range of genetic diversity, and therefore more generalizability of responses across populations.
JAX researchers have developed a growth rate index that helps scientists estimate growth rates of microbial communities.
JAX researcher Ron Korstanje is closer to understanding exactly how bear kidneys recover from the damage caused by hibernation.
A team led by JAX researcher Mauro Costa, Ph.D. has uncovered potential links between genetic heart defects and metabolism in adults. Their findings could be the first steps toward treatments to prevent the progression of heart failure.
JAX researchers have developed a new computational algorithm that is capable of modeling the effects of both stochastic gene expression and cell-to-cell variability in a cell population.
Research into autoimmune mechanisms in type 1 diabetes adds complexity but offers direction for new immune system treatments for patients.
Paper provides important insight for B-cell lymphomagenesis from mouse models to human disease.
$2.2M grant to JAX Professor David Serreze will fund search for new approaches to fighting autoimmune destruction
New JAX research offers insight into how our immune cells are able to tell the difference between helpful bacterial strains and potentially inflammatory or pathogenic strains.
The National Institute of General Medical Sciences has awarded Petko Petkov a four-year grant totaling $1,385,337 to exploit the new methods he has developed to profile and investigate zinc finger proteins and their binding sites.
JAX researchers have demonstrated the ability to target and disrupt specific genes and/or alter their expression levels, which has important implications for both immunology research and clinical treatments.
The five-year grant enables studies exploring ways to boost the hematopoietic system for better regenerative capacity, immune cell function during aging.
UConn, JAX researchers classify 40 subtypes of RGCs and identify additional subtypes, markers and transcription factors.
A new paper further explains the genomic disruption known as the tandem duplicator phenotype (TDP), a common attribute in some of the most deadly cancers of women.
Cancer cell immortality leads to massive tumors, metastatic spread, and potentially re-emergence. Researchers are working to determine how cancer cells achieve immortality.
Jackson Laboratory Assistant Professor Ewelina Bolcun-Filas, Ph.D., is looking at how multiple genetic factors regulating oocyte development determine the differences in each woman’s ovarian reserve.
JAX Associate Professor Jeffrey Chuang, Ph.D., has been awarded a five-year grant totaling $2,650,484 from the National Cancer Institute for research that could pave the way for the first evolution-based approaches to cancer treatment.
Postdoctoral Associate Price Dickson, Ph.D., is working to discover the genetic underpinnings that make individuals susceptible or resistant to addiction in the face of chronic stress.
Genetically diverse mouse population mirrors humanity in prediabetic genetic changes, point the way to new treatment possibilities.
The latest developments in cancer research and their translation to oncology practice offer truly exciting potential for better therapies in the near future.
Structural variants, or SVs, are large DNA sequences that are inserted, inverted, deleted or duplicated within genomes. Finding SVs with short-read seq and analysis methods is difficult, but a new SV identification tool, FusorSV, sets a gold standard for SV detection and analysis.
New research provides an intriguing therapy target for some forms of Charcot-Marie-Tooth disease type 2.
An invisible ally in the fight against cancer? Researchers find evidence that healthy skin microbiomes contain a bacterial strain that helps prevent cancer from growing.
Researchers have found important timing and gene expression differences between the different forms of allodynia (persistent pain following nerve damage).
Researchers recently dove deeper into the biology of human weight fluctuation and insulin resistance than ever before.
A team led by researchers at Boston University and Harvard University, and including JAX Assistant Professor Travis Hinson, M.D., used a newly developed model system, cultured human cardiomyocytes derived from induced pluripotent stem cells (iPSCs), to study the role of titin and other aspects of sarcomere assembly.
A review in the journal Cell Stem Cells by two JAX scientists reports on the latest efforts to isolate and culture the elusive populations of stem cells that most closely resemble very early (two-cell stage) totipotent cells.
A $500,000 gift by an anonymous donor from Connecticut has helped JAX launch the Tallwood Cancer Canine Research Initiative, which is focused on finding cures for human and canine cancers.
A team including JAX Professor Roel Verhaak, Ph.D., investigated genes implicated in self-renewal and therapy resistance in glioblastoma multiforme.
BRCA mutations are well-known cancer risk factors, but a particular genomic perturbation, called tandem duplications , is associated with loss of BRCA1 but not BRCA2.
A research team finds a better way to culture mouse lung progenitor cells so that they can differentiate along all epithelial lineages.
Which mutations drive cancer initiation and, in cases of recurrence, which provided therapy resistance?
Scientists at The Jackson Laboratory and UCONN Health used advance genomic profiling techniques to uncover a distinctive genomic pattern associated with aging of the immune system.
The Roopenian lab has identified cell populations that might shed light on origins of autoimmune diseases.
A recent paper in Immunity describes the complex mechanisms underlying innate lymphoid cell subset differentiation and function.
Receiving a Ph.D. in a scientific field generally involves a lot of very hard work. How does this rigorous process translate to job performance and satisfaction when so many now pursue non-traditional research paths?
Two clinical trials are testing whether vaccination boosts the likelihood of IVF pregnancy.
Does the composition of highly trained athletes’ microbiomes differ from that of other people, and what role might microbes play in the competitive landscape?
Recently, a team led by JAX Professor and Scientific Director Nadia Rosenthal, Ph.D., F.Med.Sci., and Research Scientist James Godwin, Ph.D., explored the role of the immune response in heart regeneration in the axolotl (salamander).
Cardiac macrophages could be key to treating heart disease or damage
Precisely characterizing the resulting mouse strains is crucial for learning the functions and biological mechanisms of the genes.
A team that included JAX researchers Kevin Peterson, Ph.D., and Steve Murray, Ph.D., identified two new mutations implicated in hypoplastic left heart syndrome and described the first known animal models for the disease, providing new insights into its multigenic etiology.
A cancer patient’s genetic profile may influence whether or not he or she will have a toxic response to a given chemotherapy, Jackson Laboratory researchers report in The Pharmacogenomics Journal.
JAX researcher Ewelina Bolcun-Filas, Ph.D., contributed to a study that could advance development of drugs to prevent infertility caused by cancer-treating radiation.
Where do a baby’s first microbes come from and what controls which bugs stick around?
New research shows that combination therapy of vitamin B3 and a fusion gene variant called the Wallerian degeneration slow allele prevented glaucoma in 94 percent of tested eyes.
While the human body's response to potentially carcinogenic stimuli has been extensively investigated, the exact timing and underlying mechanisms of these processes remain unclear.
The knowledge scientists like V. Narry Kim gain studying micro RNA will be useful for translational and applied research in the years ahead.
A trivalent flu vaccine outperforms a monovalent one produced by the same manufacturer, in part by triggering early interferon responses in the blood, according to Jackson Laboratory researchers and their collaborators.
An immune response triggered by high pressure in the eye occurs early in glaucoma and has a protective effect on retinal cells, a Jackson Laboratory (JAX) research team led by Professor and Howard Hughes Medical Institute Investigator Simon W.M. John, Ph.D., reports in the Proceedings of the National Academy of Sciences.
Bacteria swap viruses during intestinal infection in the mouse.
How FcRn interacts with albumin and determines its fate was previously unknown.
Developmental processes may prevent the human heart's ability to regenerate.
JAX Associate Professor Gareth Howell, Ph.D., is teaming up with the University of Rochester Medical Center’s Richard Libby, Ph.D., to determine how the endothelin system contributes to retinal cell death in glaucoma.
Many different mutations linked to Type 2 diabetes all occur in key stretches of active DNA within pancreatic islet cells, interfering with the activity of a master regulator.
The possible role of the microbiome — the bacteria, fungi and viruses living on and in us — in cancer is an intriguing area for research.
In a paper published in Cell Reports, a team of researchers including JAX Assistant Professor Travis Hinson, M.D., report how they used human cell lines in addition to an animal model to study the mechanisms of the PRKAG2 mutation.
In a commentary on the paper also appearing in Nature, Jackson Laboratory Professors Karolina Palucka, M.D., Ph.D., and Jacques Banchereau, Ph.D., show how a four-pronged therapeutic strategy led to complete responses for large tumors.
Using mice spanning a spectrum of ages, a Jackson Laboratory research team led by Assistant Professor Jennifer Trowbridge, Ph.D., investigated changes in the maturation process of hematopoietic stem cells over time.
Researchers at JAX and the University of Texas Southwestern Medical Center have identified two genes that play significant roles in maintaining regular sleep.
A research team led by JAX Assistant Professor Michael Stitzel, Ph.D., isolated single cells from the pancreatic islets of both non-diabetic and type 2 diabetic subjects to obtain transcriptomes for each cell.
New research shows autoimmune events early in life in the spleen can drive later autoimmunity and disease pathology in local tissues.
Work by a team including JAX Assistant Professor Basile Tarchini, Ph.D., is shedding light on the mechanism that directs the assembly of the staircase pattern of the hair bundle.
Scientists have developed and implemented a new microscopy method that allows resolution of three-dimensional structures to 10-20 nm throughout entire cells, in samples up to 10 microns thick.
A form of benign lung tumor known as pulmonary sclerosing hemangioma (PSH) has been shown to share its origin with malignant lung adenocarcinoma.
Researchers led by JAX Professor Peter Robinson, Ph.D., developed “Genomiser,” a new tool that combines machine learning and an algorithm for ranking non-coding variants.
Researchers describe an automated, high-throughput platform that allows simultaneous investigation of genotype, gene expression and DNA methylation at multiple locations in the genomes of single cells.
A long-standing question in the study of thalamic function is whether TRN neurons form GABAergic synapses with other TRN neurons.
Circulating tumor cells in the blood of cancer patients have attracted intense scrutiny because of the potential they offer as easily accessible biomarkers and indicators of therapeutic response.
Vaccines represent some of the most effective preventive medical advances ever. They have greatly reduced or all but eliminated many of our most feared and dangerous infectious diseases and have saved countless lives. And that’s how most people think of them—as preventing infectious diseases by priming the body’s immune system to immediately recognize and eliminate pathogens.
New sequencing tools are uncovering how the unpacked sections of DNA can interact with each other in three-dimensional space, leading to new insights in the relationships between distant sections of DNA.
Despite near-constant assaults from bacteria, the microbial community on your hands is remarkably stable.
Estimates of the precise numbers vary, but it’s widely known that we have several times more microbial cells on and in our bodies than our own cells. And overall those microbial cells express a nearly 30-fold greater variety of protein-encoding genes than ours do, often working in concert with our own systems.
When cells come under environmental stress, they employ a variety of molecular adjustments to survive, new research from The Dai Lab reveals.
The Y chromosome is pretty amazing. In humans, it determines male sex, but for a long time it was given short shrift due to its paucity of protein coding, which some researchers found uninteresting. Furthermore, its abundance of short tandem repeats (STRs) made sequencing and subsequent positioning difficult.
Researchers including Jacques Banchereau of The Jackson Laboratory have uncovered seven major molecular subgroups of patients with systemic lupus erythematosus (SLE), providing an explanation for the failure of treatments for the disease in clinical trials and opening opportunities for new and more targeted treatments of the disease. Their findings are published in the journal Cell.
Vascularization defects contribute to neuron loss in a mouse model for Alzheimer’s disease
In addition to sequence, three-dimensional (3D) genome structure contributes to vital functions, including transcriptional regulation, DNA replication and DNA methylation.
One of the most exciting fields in all of biomedical research right now is oncoimmunology. The premise is simple: Get a cancer patient’s immune system to recognize cancer cells as foreign, as they do a virus or bacterium, and mount a response to kill them.
We carry genetic traits from both our parents. But did you know that we are often healthy even when we have two faulty copies of the same gene?
The processes leading to many neurodegenerative diseases remain unknown despite intense research scrutiny. For example, we still don’t know why, in some people, enough neural cells die to impair movement (in neuromuscular diseases such as amyotrophic lateral sclerosis (ALS)) and cognition (in neurodegenerative diseases such as Alzheimer’s and other dementias).
JAX research provides insight into the role of the western diet in Alzheimer’s disease.
“Microbial dark matter" undoubtedly contains key information about how our microbiome contributes to human health and disease. But how do you study something you can’t see?
Effective interpretation and identification of causative and actionable mutations in disease states is still a major hurdle to the delivery of personalized genomics.
Assistant Professor Zhengqing Ouyang, Ph.D., received a one-year, $100,000 Research Starter Grant in Informatics from the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation.
In an article published the week in the journal Human Molecular Genetics, Gayle Collin, working in the laboratory of Patsy Nishina at the Jackson Laboratory in Bar Harbor, describes a new murine model of the human vision disorders.
Most cases of amyotrophic lateral sclerosis (ALS) are sporadic, meaning that there is no family history of the disease.
The National Institute of Biomedical Imaging and Bioengineering, an institute of the National Institutes of Health (NIH), awarded Associate Professor Jeffrey Chuang was awarded a three-year, $390,000 grant for “Big Genomic Data Skills Training for Professors.”
In an article published in Nature Genetics in November, Candice Baker and Stephen Murray of JAX Bar Harbor were members of a team investigating genes that may be responsible for heterotaxy in humans.
New multi-institutional group of leading microbiome researchers seeks to deepen our knowledge of the microbiome and apply lessons from this emergent area of research.
Charcot-Marie-Tooth (CMT) diseases are the most common family of inherited diseases called peripheral neuropathies. The junctions between muscles and nerves and the nerves themselves that carry signals between brain and muscles degenerate over time, leading to impaired movement, including balance problems and difficulty walking. CMT diseases have a range of severity but are rarely life-threatening.
As we age, it becomes more difficult to maintain good health, and we become more susceptible to diseases such as cancer, heart disease and stroke with each passing year. That fact seems so basic that it’s surprising that no one really understands the basic mechanisms underlying aging and why the aging process has such a large impact on wellbeing. And as researchers delve deeper into the subject, answers remain elusive.
Retroviruses are known to spread between cells in vitro, but mechanisms for spread in vivo are not well understood. Knowledge of how the spread occurs is important for improving HIV prevention and therapies.
Assistant Professor Gareth Howell, Ph.D., received a two-year grant from the National Institute of Neurological Disorders and Stroke (NINDS) to more accurately model the role of the human complement cascade for disease research.
The single-cell technology, methods and expertise Paul Robson brings to JAX have the potential to advance many of the ongoing research programs.
New research from the University of California Davis and The Jackson Laboratory provides more evidence that patient-derived xenografts (PDXs), human tissues implanted in immunocompromised mice, can provide powerful insight into cancer mechanisms and therapies.
Professor Karolina Palucka, M.D., received an RO1 grant award for “Humanized mouse models to dissect in vivo the interplay between melanoma and the immune system."
Mice that receive sporadic, high-level doses of antibiotics—emulating typical prescriptions for children—experience significant changes in body composition and microbiome.
Working with research partners, the Jackson Laboratory genetically engineers new mouse models, from construct creation and microinjection to evaluation and characterization.
CHDI Foundation, The Jackson Laboratory, and PsychoGenics, Inc. have developed a new field guide for researchers studying Huntington's disease.
The term epilepsy refers to a spectrum of brain disorders resulting from a disturbance of the normal pattern of neuron activity.
According to the CDC, approximately 1 in 88 U.S. children has an autism spectrum disorder. Scientists are using mouse models to better understand the disorder.
The Jackson Laboratory develops models for Friedreich’s ataxia that are well-standardized, genetically stable, and available to the scientific community.
Spinal muscular atrophy (SMA) is a recessive disease and the leading genetic cause of infant and toddler death worldwide, affecting 1 in every 10,000 live births.