JAX researchers are at the forefront of advancing the understanding of the genetic factors involved in individuals’ vulnerability to addiction. Researchers have established a strong genetic component for addictive behaviors through studying animal models, including laboratory mice. Different mouse strains, which have different genetic backgrounds, show different levels of preference for addictive substances.
By blending classical and cutting-edge genetic approaches, Vivek Kumar, Ph.D.Understand the genetic and neurobiological basis of complex behaviors that are important in psychiatric conditions such as addiction, ADHD, and depression using genomic, neural circuit, and computational tools.Vivek Kumar is unveiling the genes at work within the brain to control complex behaviors, such as anxiety and addiction. By understanding the biological reasons some people are at greater risk for addiction, Kumar hopes to find new ways to prevent people from being addicted and get help for those who are already addicted and need help now.
In her lab, Elissa Chesler, Ph.D.Develops software tools and resources for multi-species data integration in the study of health and disease and researches the genetic and biological basis for relationships among behavioral traits including addiction and other behaviors.Elissa Chesler researches the genetics underlying behavior and is pinpointing the relationships among behavioral traits. Her research has led to a gene library for researchers around the world, where they can mine archived genetic data for new insights into alcoholism and addiction research.
Our goal is to find new ways to prevent addiction in people who are at risk and give doctors the tools they need to guide the choices of medications patients should take before addiction takes hold and ruins lives.