Researches the genetics of aging and lifespan, seeking to understand the basic mechanisms of aging, and adult stem cells, with the goal of delaying normal aging processes.
Pathology is the mother of medicine.
The study of structural genomic variation in human biology, evolution and disease
Bridging the digital biology divide, integrating computation with biomedical research.
I lead a collaborative and interinstitutional research program that uses a multidisciplinary approach to identify early causative events underlying ‘normal’ nonpathological age-related memory decline and Alzheimer’s dementia.
Analyzing sequence and assay data to better understand genome function.
Researches human pancreatic islet cells and the genetic and environmental bases of type 2 diabetes.
Models genome regulation using computational and statistical methods.
Elucidating the structures and dynamics of complex genomes.
Investigating the mechanisms of autoimmune disease to devise therapeutic approaches.
Develops immunodeficient mouse models and optimizes technologies for effective human cell and tissue engraftment.
Enabling the development of novel therapies for serious illnesses.
Researching the fundamental genomics of breast cancer.
Studying the mechanisms of human immunity and developing cancer immunotherapies.
Studies neural circuits in the brain and associated behavioral abnormalities.
Studies the genetics of kidney function and disease, particularly in the context of aging.
Investigates the early stages of age-related neurodegenerative diseases.
Leverages advanced technologies to investigate infectious diseases, human and other mammalian microbiomes, and their clinical impact.
Investigating the genetic basis of autoimmunity and type 1 diabetes.
The Unutmaz Lab investigates the biology of the human immune system.
Researching the mechanisms of DNA damage detection and repair and their implications for cancer patients.
Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.
Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.
Researches genome informatics with a focus on gene ontology.
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
Researching the mechanisms that generate genetic diversity through the lens of evolution
Investigating the genetics of health and disease with a systems approach.
Investigates how RNA splicing contributes to breast and ovarian cancer progression, metastasis and drug-resistance.
Uses advanced methods to research glaucoma and other neurodegenerative diseases.
We are passionate about the development and application of computational modeling methods to study the operating mechanisms of cancer genetic networks.
Functional genomics and epigenetic modification
Investigating the genetic mechanisms of craniofacial development and developing new genetic tools and resources for the scientific community.
Researches the genetics underlying behavior and identifies relationships among behavioral traits.
The Oh Lab studies the human microbiome for its potential to deliver treatments for infectious and other diseases. (Image by Alex Valm, NHGRI)
The Cheng lab develops technologies based on artificial DNA and RNA binding proteins and applies them to sense or induce sequence or epigenetic changes at target genomic loci or target transcripts.
Researches blood formation with a focus on red blood cells and the genetics underlying defects leading to anemias.
Uses mathematical algorithms to model and simulate molecular networks.
Investigates the genetics of metabolic syndrome and ciliopathies.
Investigates the molecular mechanisms shaping hair cell architecture in the inner ear
Researches the molecular pathways of human degenerative muscle diseases.
Investigates the genetic regulation of meiosis and the mechanisms of male fertility to understand how errors in meiosis can lead to developmental abnormalities.
Studies synapse development and function relevant to human neuromuscular disorders.
Researches genetic recombination, exploring the mechanisms that determine its location and DNA binding specificity.
Investigating gamete development with a focus on spermatogenesis.
Researches the molecules and pathways important to the development and physiology of the ear, with a focus on hearing loss and impairment.
Bridges immunology, genomics research and bioinformatics to develop a deeper understanding of asthma pathogenesis.
Develops computational methods to study the epigenetic regulation of gene expression and its implications in important human conditions including aging and common diseases.
Captures gene expression data and disseminates it to the research community.
Studying the development and function of neural circuits and dysfunctions related to autism spectrum disorders.
Developing new computational strategies to understand complex genetic systems.
Dr. Reinholdt’s research focuses on comparative and functional mammalian genomics, reproductive development and stem cell biology.
Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders.
Brain tumors, sequencing, computational biology.
Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.
Assessing the performance of next-generation sequencing techniques in accurate genome/epigenome/transcriptome profiling and understanding the clinical and functional role of epigenome heterogeneity in the cancer evolution.
Human pluripotent stem cells and the human embryo: Human pluripotent stem cells (hPSC) have opened up a previously inaccessible phase of the human life cycle to experimental study.