Research Labs

Elucidating the structures and dynamics of complex genomes.

The Adams lab develops new approaches for human and mouse microbiome analysis, seeks to understand the evolution of antibiotic resistance in Gram-negative pathogens, and contributes to clinical assay development for the JAX CLIA Laboratory.

Investigates how alternative RNA splicing contributes to cancer with the goal of identifying novel clinical biomarkers and targets for precision medicine.

Functional genomics and epigenetic modification

The Beck lab uses genomics, bioinformatics and molecular biological techniques to investigate the ways in which repetitive DNA elements, such as transposons, affect human genomes.

Researches genome informatics with a focus on gene ontology.

The Bloss Lab leverages high resolution imaging strategies with activity and genetic perturbations of specific neurons in behaving mice to define how the synaptic architecture of neural circuits supports goal-directed behavior.

Researching meiosis, the mechanisms of DNA damage detection and repair during normal development of gametes, and implications for fertility of cancer patients after radiation and chemotherapy.

Investigating gamete development with a focus on spermatogenesis.

Bridging the digital biology divide, integrating computation with biomedical research.

Studies synapse development and function relevant to human neuromuscular disorders.

Developing new computational strategies to understand complex genetic systems.

Researches the genetics underlying behavior and identifies relationships among behavioral traits.

Analyzing sequence and assay data to better understand genome function.

Investigating the genetics of health and disease with a systems approach.

Researches the molecular pathways of human degenerative muscle diseases.

Researching the mechanisms that generate genetic diversity through the lens of evolution

Investigates the genetic regulation of meiosis and the mechanisms of male fertility to understand how errors in meiosis can lead to developmental abnormalities.

Researches the genetics of aging and lifespan, seeking to understand the basic mechanisms of aging, and adult stem cells, with the goal of delaying normal aging processes.

Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders.

Investigates the early stages of age-related neurodegenerative diseases.

I lead a collaborative and interinstitutional research program that uses a multidisciplinary approach to identify early causative events underlying ‘normal’ nonpathological age-related memory decline and Alzheimer’s dementia.

Studies the genetics of kidney function and disease, particularly in the context of aging.

We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.

Using genomic technologies and mouse modeling including patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM), we are discovering and validating novel biomarkers and therapeutic targets of pediatric cancers

The Lee Lab studies structural genomic variation in human biology, evolution and disease.

Assessing the performance of next-generation sequencing techniques in accurate genome/epigenome/transcriptome profiling and understanding the clinical and functional role of epigenome heterogeneity in the cancer evolution.

Researching the fundamental genomics of breast cancer.

Steven Munger, Ph.D., uses a systems genetics approach and advanced computational methods to study development and complex disease in advanced mouse populations.

We investigate how signaling programs instruct in vivo stem cells of the cochlea to differentiate into a highly specialized, organized sensory epithelium.

Investigating the genetic mechanisms of craniofacial development and developing new genetic tools and resources for the scientific community.

Investigates the genetics of metabolic syndrome and ciliopathies.

Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.

The overarching goal of my NIH-funded research program is to understand the neural control of appetite and how diet and body weight affect the excitability of the neurons in key CNS circuits responsible for food intake.

The Oh Lab studies the human microbiome for its potential to deliver treatments for infectious and other diseases. (Image by Alex Valm, NHGRI)

Studying the mechanisms of human immunity and developing cancer immunotherapies.

Human pluripotent stem cells and the human embryo: Human pluripotent stem cells (hPSC) have opened up a previously inaccessible phase of the human life cycle to experimental study.

Researches blood formation with a focus on red blood cells and the genetics underlying defects leading to anemias.

Dr. Reinholdt’s research focuses on comparative and functional mammalian genomics, reproductive development and stem cell biology.

To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse

Captures gene expression data and disseminates it to the research community.

Develops algorithms and software for the analysis of exome and genome sequences.

Investigating the mechanisms of autoimmune disease to devise therapeutic approaches.

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

The overall focus of my research program has been to understand the molecular and cellular mechanisms underlying tissue growth and tissue regeneration with the long-term goal of developing new strategies for treating human diseases.

Investigating the genetic basis of autoimmunity and type 1 diabetes.

Investigates human immunological diseases and malignancy through the development and leveraging of novel humanized mouse models

The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins.

Researches human pancreatic islet cells and the genetic and environmental bases of type 2 diabetes.

Investigates the molecular mechanisms shaping hair cell architecture in the inner ear

Our lab is focused on identifying and understanding the precise genetic mechanisms influencing human complex traits and risk to disease. To accomplish this our work spans several areas of interest.

Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.

Develops computational methods to study the epigenetic regulation of gene expression and its implications in important human conditions including aging and common diseases.

The Unutmaz Lab investigates the biology of the human immune system.

Brain tumors, sequencing, computational biology

We develop and apply innovative genome technologies to understand chromatin structure and genome function pertinent to lineage specification and disease process.

Leverages advanced technologies to investigate infectious diseases, human and other mammalian microbiomes, and their clinical impact.