Metabolic Diseases

Leverage the world's largest collection of diabetes and obesity mouse models and more than 80 years of research expertise by using one of our metabolic disease strains for your investigations.

Featured JAX® Mice models of type 2 diabetes & obesity

Detailed phenotypes for the most popular and newly emerging models of human type 2 diabetes & obesity.

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Choosing mice for diabetes and obesity research

Factors to consider when choosing diabetes and obesity mouse models

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Comparison of mouse & human phenotypes

Comparison of the major type 2 diabetes and obesity phenotypes among humans and 7 widely used mouse models.

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Diabetes & Obesity Research Tools and Online Resources

Discover the Mouse Phenome Database and other online resources for type 2 diabetes and obesity research.

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STZ-induced diabetes models

The streptozotocin (STZ) model of diabetes is available for C57BL/6J, NOD scid and NSG™ males. Protocols can be modified for other strains and sexes.

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Type 1 Diabetes Resource

The National Center for Research Resources (NCRR) at NIH has funded a Type 1 Diabetes Resource at The Jackson Laboratory.

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Additional selected JAX® Mice

Models that may be used as tools in diabetes & obesity research.

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All JAX® Mice for diabetes & obesity research

Find comprehensive strain options based on phenotype and/or disease manifestation.

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Diet-Induced Obesity Models

JAX maintains an inventory of diet-induced obesity (DIO) models, and can place any strain on any fully customized diet so that your mice are ready when you need them.

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Metabolic Disease Models Poster

This poster compares the benefits and considerations for the top 10 metabolic disease mouse models from JAX.
- Metabolic Diseases
- Diabetes

Webinar: Everything but the Experiment: Tips for Working with Diabetic Mice

Genetic alterations predispose mice to develop human-like diabetes phenotypes. However, overlooking the environmental factors that influence those phenotypes can confound research results.
- Diabetes