In a paper published in the Proceedings of the National Academy of Sciences, researchers show that JAX Mighty Mice stayed relatively mighty during their time in microgravity, while the normal control mice lost considerable muscle mass and bone density.
Humanized mouse models serve as an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in combination, and produce predictive data. But, there are a number of questions that frequently arise with this model. Here are some of the more frequent questions and answers to using CD34+ hematopoietic stem cell humanized mice.
A review in the journal Cell Stem Cells by two JAX scientists reports on the latest efforts to isolate and culture the elusive populations of stem cells that most closely resemble very early (two-cell stage) totipotent cells.
Using mice spanning a spectrum of ages, a Jackson Laboratory research team led by Assistant Professor Jennifer Trowbridge, Ph.D., investigated changes in the maturation process of hematopoietic stem cells over time.