The Jackson Laboratory is at the forefront of the new thinking about how the body’s immune response and inflammation contribute to a variety of diseases, including cancer and diabetes.
NOD-scid IL2rgnull (NSG) and NOD-Rag1null IL2rgnull (NRG) mice support heightened levels of engraftment with human cells and tissues. These engrafted mice allow research on human disease processes without putting individuals at risk.
Develops computational methods to study the epigenetic regulation of gene expression and its implications in important human conditions including aging and common diseases.
The Mouse Peroxisome Research Resource (MPRR) at the Jackson Laboratory serves as a centralized resource for mouse models and monoclonal antibodies for basic and translational research relevant to peroxisome biology and disorders caused by peroxisome dysfunction.
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. The Mouse Mutant Resource maintains over 700 established mutant strains.