The Jackson Laboratory is at the forefront of the new thinking about how the body’s immune response and inflammation contribute to a variety of diseases, including cancer and diabetes.
NOD-scid IL2rgnull (NSG) and NOD-Rag1null IL2rgnull (NRG) mice support heightened levels of engraftment with human cells and tissues. These engrafted mice allow research on human disease processes without putting individuals at risk.
The Cheng lab develops technologies based on artificial DNA and RNA binding proteins and applies them to sense or induce sequence or epigenetic changes at target genomic loci or target transcripts.
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. The Mouse Mutant Resource maintains over 700 established mutant strains.
Develops computational methods to study the epigenetic regulation of gene expression and its implications in important human conditions including aging and common diseases.
