In this webinar, learn how mouse models are leveraged to evaluate the efficacy of cytokine (IL-15) biologics with a focus on Tri-specific Killer Engagers (TriKE) with an NK cell binding arm (anti-CD16), a tumor associated binding arm (TAA), and an IL-15 moiety. See how NSG mice are used to develop cancer models to explore how TriKE molecules impact tumor growth through NK cells. JAX state-of-the-art CD34+ huNSG-FLT3-IL15 (NSG-F15) platform is used to explore therapeutic efficacy in more complex immune systems and NK cell activation within the tumor microenvironment.
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