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Research HighlightSeptember 27, 2023Exploring how genetics affects Alzheimer's disease
A research team led by Assistant Professor Erik Bloss and Professor Gareth Howell, and including predoctoral associate Sarah Heuer, explores how different genetic contexts affect the impact of early-stage Alzheimer's disease on neuronal circuits. -
Blog PostJune 22, 2020How to address secondary findings from genomic testing
Consider this scenario: Jayne is 50 years old and has experienced progressing neurological symptoms over the past two years with no diagnosis. She recently had exome testing which show no genetic variants that explain her symptoms, but identifies a pathogenic variant (mutation) in MSH6. -
Blog PostMay 31, 2019The Versatile Mouse Model for Rare Disease Research
There are more than 7,000 rare (also known as orphan) diseases affecting over 350 million people worldwide. Developing new therapies for rare diseases is very challenging, given the small patient populations available for clinical trials. Therefore, animal models, in particular genetically engineered mice, have become one of the most valuable assets in all of the phases of preclinical orphan drug development. -
Press ReleaseDecember 27, 2018New Alzheimer's mouse models show how human diversity affects disease onset
A new genetically diverse mouse population is opening possibilities for translational research into Alzheimer’s disease that accurately recreates human disease symptoms and progression.
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Featured ArticleOctober 01, 2020Virtual forum: Finding resilience-based targets for Alzheimer's disease
The key to discovering a therapeutic for Alzheimer’s disease is identifying resilience, according to The Jackson Laboratory researcher who created the first-ever Alzheimer’s disease mouse population. -
Search MagazineDecember 02, 2019Mighty Mice in the classroom
A Jackson Laboratory mission to study muscle and bone loss on the International Space Station also launches a STEM project for students here on Earth. -
Research HighlightMarch 08, 2019Long-range connectivity and gene regulation networks
A complicated three-dimensional network involving proteins and specific DNA sequences helps regulate the expression of genes. New work led by JAX’s Chia-Lin Wei shows how one protein, SOX2, plays a significant role in neural stem cells, affecting many aspects of development and function. -
Research HighlightDecember 14, 2018Gene knockdown induces deficits reminiscent of aging and Alzheimer's
JAX researchers find that reducing Hp1bp3 expression mimics age-related cognitive decline through mechanisms reminiscent of aging and Alzheimer's disease
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