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Neurodegenerative Disease

The Jackson Laboratory addresses a wide range for research topics regarding neurological function and dysfunction, from developmental processes and sensory disorders to neuron degeneration.

JAX researchers identify mutations in Charcot-Marie-Tooth disease that worsen peripheral nerve damage

Press Release March 30, 2017 Learn More

Our mouse model paved the way for a new SMA drug

The Search Magazine Article February 28, 2017 Learn More

News and Insights

Press ReleaseMarch 30, 2017

JAX researchers identify mutations in Charcot-Marie-Tooth disease that worsen peripheral nerve damage

The Search Magazine ArticleFebruary 28, 2017

Our mouse model paved the way for a new SMA drug

eNewsAugust 17, 2016

MicroRNAs and Parkinson's Disease

Press ReleaseAugust 17, 2016

NIH grant will fund new JAX resource for peripheral neuropathy research

Press ReleaseMay 09, 2016

New insight in sphingolipid formation reveals neurodegenerative process

eNewsMay 08, 2016

Memory loss reversed in mouse models of early Alzheimer’s Disease

eNewsApril 12, 2016

Reduced MeCP2 signaling leads to hypoalgesia in a mouse model of Rett syndrome

eNewsMarch 29, 2016

Electron microscopy reveals dark microglia and their novel phenotype

Research HighlightMarch 16, 2016

More than beta amyloid

eNewsMarch 02, 2016

Copper therapy halts disease progression in ALS mice

Research HighlightFebruary 26, 2016

Hyperactive Somatostatin Interneurons

eNewsFebruary 11, 2016

Postdoctoral fellowships to study the complex etiology of Alzheimer's disease

eNewsJanuary 21, 2016

Toward more predictive genetic mouse models of Alzheimer's disease

Blog Post December 28, 2015

What to watch for in precision medicine in 2016

eNewsDecember 21, 2015

Which comes first, synapse loss or dendritic remodeling during glaucoma?

Related Services

Neurobiology

Most popular JAX Mice strains

Mouse Biospecimens

Breeding Services

Education Resources

Aug 20 - 27
Workshop

Workshop on Techniques in Modeling Human Cancer in Mice

Endocrinology, Genetic Tools, Rare Diseases, Neurodegenerative Disease, Cancer/Tumors, Genetics and Genomics, Cancer
Oct Nov 30 - 03
Short Course

21st Century Mouse Genetics

Genetic Tools, Model Development, Neurodegenerative Disease, Rare Diseases, Reproductive Biology, Aging, Developmental Biology, Cancer/Tumors, Diabetes, Bioinformatics, Complex Traits, Cancer, Computational Biology, Genetics and Genomics
Oct 22 - 28
Workshop

Principles and Techniques in Mouse Behavioral Phenotyping and Pharmacology

Model Development, Neurodegenerative Disease, Neuroscience, Behavioral and Cognitive Impairment, Optogenetics and Pharmacogenetics, Ataxia Movement Defects, Neuromuscular Defects, Autism, Learning deficits, Rett Syndrome, Neurodevelopmental Defects, Behavioral Disorders, Complex Traits, Developmental Disorders, Neurodegenerative and Neuromuscular Diseases, Resource Development and Dissemination

Research & Faculty

Postdoctoral Associate

Postdoctoral Associate

The Cox Lab

Researches the molecular pathways of human degenerative muscle diseases.

Cynthia Smith, Ph.D.

Research Scientist

David Hill, Ph.D.

Research Scientist

Director, Center for Biometric Analysis

James Kadin, Ph.D.

Senior Research Scientist

Jurgen Naggert, Ph.D.

Professor

Kenneth Johnson, Ph.D.

Associate Professor

Kevin Seburn, Ph.D.

Research Scientist

Study Director

Michael Sasner, Ph.D.

Research Scientist

Molly Bogue, Ph.D.

Research Scientist

Mouse Genome Informatics

International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.

The Ouyang Lab

Models genome regulation using computational and statistical methods.

Parkinson's Disease Mouse Model Resource

The Parkinson’s Disease Mouse Model Resource characterizes and distributes new mouse models of Parkinsonism and Parkinson’s disease.

Peripheral Neuropathy Resource

Serves as a centralized resource for mouse models and tools that have been validated for use in preclinical studies of peripheral neuropathy.

Simon John, Ph.D.

Professor and Howard Hughes Medical Investigator

Yair Dorsett, Ph.D.

Associate Research Scientist

Zhengqing Ouyang, Ph.D.

Assistant Professor