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Featured ArticleApril 25, 2024Postdocs discuss neurodegenerative conditions for 'Scientifically Speaking'
JAX’s 'Scientifically Speaking' virtual series continues May 7, featuring two postdoctoral associates taking on the challenge of neurodegenerative disease. -
Research HighlightSeptember 27, 2023Exploring how genetics affects Alzheimer's disease
A research team led by Assistant Professor Erik Bloss and Professor Gareth Howell, and including predoctoral associate Sarah Heuer, explores how different genetic contexts affect the impact of early-stage Alzheimer's disease on neuronal circuits. -
Blog PostJune 22, 2020How to address secondary findings from genomic testing
Consider this scenario: Jayne is 50 years old and has experienced progressing neurological symptoms over the past two years with no diagnosis. She recently had exome testing which show no genetic variants that explain her symptoms, but identifies a pathogenic variant (mutation) in MSH6. -
Blog PostMay 31, 2019The Versatile Mouse Model for Rare Disease Research
There are more than 7,000 rare (also known as orphan) diseases affecting over 350 million people worldwide. Developing new therapies for rare diseases is very challenging, given the small patient populations available for clinical trials. Therefore, animal models, in particular genetically engineered mice, have become one of the most valuable assets in all of the phases of preclinical orphan drug development.
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Featured ArticleNovember 21, 2023Advancing Alzheimer's disease research
To solve Alzheimer’s disease, JAX's Kristen O'Connell is working to understand the biological factors that cause it. -
Featured ArticleOctober 01, 2020Virtual forum: Finding resilience-based targets for Alzheimer's disease
The key to discovering a therapeutic for Alzheimer’s disease is identifying resilience, according to The Jackson Laboratory researcher who created the first-ever Alzheimer’s disease mouse population. -
Search MagazineDecember 02, 2019Mighty Mice in the classroom
A Jackson Laboratory mission to study muscle and bone loss on the International Space Station also launches a STEM project for students here on Earth. -
Research HighlightMarch 08, 2019Long-range connectivity and gene regulation networks
A complicated three-dimensional network involving proteins and specific DNA sequences helps regulate the expression of genes. New work led by JAX’s Chia-Lin Wei shows how one protein, SOX2, plays a significant role in neural stem cells, affecting many aspects of development and function.
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