Utilizing the most translationally-relevant in vivo model is crucial to generating meaningful data and getting a potential therapeutic closer to Investigational New Drug Application (IND) filing. With the availability of the MSNASH/PcoJ mouse from JAX, which can be used to study obesity, diabetes, and metabolic syndrome—including NASH, researchers worldwide can access and include this in vivo model that offers several benefits over the previously published models.
An elegant clinicopathologic characterization of a Diet-Induced Animal Model of Non-alcoholic fatty liver Disease (DIAMOND) reminds us of a simple truth about how many discoveries are made: by paying attention and being prepared to recognize the value of an unexpected finding.
Studies in mice suggest that resveratrol, a plant-derived compound, may be beneficial in treating or preventing a host of cardiovascular, metabolic, autoimmune and neurodegenerative diseases.