NOD-scid IL2rgnull (NSG) and NOD-Rag1null IL2rgnull (NRG) mice support heightened levels of engraftment with human cells and tissues. These engrafted mice allow research on human disease processes without putting individuals at risk.
The Cre Portal contains curated data about all recombinase-containing transgenes and knock-ins developed in mice to provide a comprehensive resource delineating known recombinase activity patterns and allowing users to find relevant mouse resources for their studies.
Tools for automatic glomerulus identification and histological quantification from scanned PAS slides
Phenotype and RNAseq data from approx. 200 (B6-Col4a5 KO x DO)F1 mice
Describes mouse models for ocular research available at The Jackson Laboratory and provides a list of known mouse mutations that affect vision.
Professor, Karl Gunnar Johansson Chair
Genetic Resource Science initiates and develops resource-generating research. Our team: identifies and implements innovative technologies for genetic research; makes and distributes new mouse models; and provides extensive genetic and phenotypic information on JAX mouse strains.
This tool calculates the glomerular filtration rate in mice using the FITC-inulin method
Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders.
Integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure
ATAC-seq is a new protocol to capture open chromatin sites by performing adaptor ligation and fragmentation of open chromatin regions. Due to its efficiency in requirement of biological sample and in library preparation time, many scientists are generating ATAC-seq libraries to decipher the chromatin landscape of DNA in a given cell type and condition of interest.
Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse Project (KOMP) which is providing critical tools for understanding gene function and the genetic causes of human diseases.
MAV-seq (Management, Analysis, Visualization of Sequence data) is an interactive, user friendly, cross platform, secure, encrypted, automated, customized, centralized, multi-roles based database application for the management of sample repertoires and automation of the data pre-processing of epigenomic and transcriptomic data.
The Mouse Models of Human Cancer Database (formerly, the Mouse Tumor Biology database) integrates data on the frequency, incidence, genetics, and pathology of neoplastic disorders, emphasizing data on tumors that develop characteristically in different genetically defined strains of mice.
Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. The Mouse Mutant Resource maintains over 700 established mutant strains.
This resource provides mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial syndromes.
The Parkinson’s Disease Mouse Model Resource characterizes and distributes new mouse models of Parkinsonism and Parkinson’s disease.
The SMSR maintains mice that are important tools for genetic analysis of complex diseases, including consomic strains.
The WORM Human OrthoLogy Explorer is a meta-tool that uses machine learning to predict novel least diverged orthologs (LDOs) by integrating ortholog predictions from 17 algorithms.