Our CRISPR/Cas mouse model creation service offers an all-in-one customized package, rapidly delivering KO and KI models for your research.
JAX® Mice are the highest quality and most-published mouse models in the world. Take advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.
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Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief guide we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.
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NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. This guide explains why the interactions between human immune cells and tumors are paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.