Research & Faculty
Featured
Human Y chromosome variability revealed
The human Y chromosome sequence was only completed this year, the last chromosome to be fully sequenced. Charles Lee has led an effort to generate 43 full sequences, and the results show large Y chromosome differences between individuals in both size and structure, with potential implications for function and health.
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Realizing the promise of the genomic era
For more than 90 years, research at JAX has expanded knowledge of mammalian genetics and contributed to medical progress. Now, at its Bar Harbor, Maine, and Farmington, Connecticut, research campuses, JAX is poised to bridge the gaps between biological knowledge and medical progress. With unmatched model organism research expertise and resources and modern research methods and tools in hand, JAX scientists are accelerating both basic discovery and clinical translation for patient benefit.
Fast facts about JAXSearch Labs
The Jalili Lab
The Jalili Research Group at The Jackson Laboratory (JAX) is focused on interrogating the host immunity, microbiome and their interface using different engineering tools in the…
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The Varn Lab
Integrates genomic and molecular pathology approaches to investigate how the tumor microenvironment drives development and treatment resistance in brain tumors
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The Wang Lab
The Wang Laboratory at The Jackson Laboratory for Genomic Medicine is interested in understanding gene regulatory mechanisms that regulate leukemia survival, differentiation and…
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The Pera Lab
Human pluripotent stem cells and the human embryo: Human pluripotent stem cells (hPSC) have opened up a previously inaccessible phase of the human life cycle to experimental study.
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The Agoro Lab
The Agoro lab uses systems biology approaches to determine how iron-driven kidney oxidative stress influences FGF23-mediated phosphate excretion in aging, chronic kidney disease and…
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The West Lab
The West Lab investigates how mitochondria shape immune and inflammatory responses in genetic disorders and aging-related diseases.
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The Peters Lab
Researches blood formation with a focus on red blood cells and the genetics underlying defects leading to anemias.
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The Lee Lab
The overall focus of my research program has been to understand the molecular and cellular mechanisms underlying tissue growth and tissue regeneration with the long-term goal of…
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The Reinholdt Lab
Dr. Reinholdt’s research focuses on comparative and functional mammalian genomics, reproductive development and stem cell biology.
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The Palucka Lab
Studying the mechanisms of human immunity and developing cancer immunotherapies.
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The Robinson Lab
Develops algorithms and software for the analysis of exome and genome sequences.
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The Anczukow Lab
Investigates how alternative RNA splicing contributes to cancer with the goal of identifying novel clinical biomarkers and targets for precision medicine.
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The Ringwald Lab
Captures gene expression data and disseminates it to the research community.
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The O'Connell Lab
The overarching goal of my NIH-funded research program is to understand the neural control of appetite and how diet and body weight affect the excitability of the neurons in key …
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The Ren Lab
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
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The Roopenian Lab
Investigating the mechanisms of autoimmune disease to devise therapeutic approaches.
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The Nishina Lab
Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.
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The Tewhey Lab
Our lab is focused on identifying and understanding the precise genetic mechanisms influencing human complex traits and risk to disease. To accomplish this our work spans several…
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The Trowbridge Lab
Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.
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The Beck Lab
The Beck lab uses genomics, bioinformatics and molecular biological techniques to investigate the ways in which repetitive DNA elements, such as transposons, affect human genomes.
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The Ucar Lab
Develops computational methods to study the epigenetic regulation of gene expression and its implications in important human conditions including aging and common diseases.
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The Li Lab
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental…
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The Shultz Lab
Investigates human immunological diseases and malignancy through the development and leveraging of novel humanized mouse models
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The Wei Lab
We develop and apply innovative genome technologies to understand chromatin structure and genome function pertinent to lineage specification and disease process.
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The Burgess Lab
Studies synapse development and function relevant to human neuromuscular disorders.
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The Adams Lab
The Adams lab develops new approaches for human and mouse microbiome analysis, seeks to understand the evolution of antibiotic resistance in Gram-negative pathogens, and contributes …
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The Stitzel Lab
Researches human pancreatic islet cells and the genetic and environmental bases of type 2 diabetes.
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The Tarchini Lab
Investigates the molecular mechanisms shaping hair cell architecture in the inner ear
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The Murray Lab
Investigating the genetic mechanisms of craniofacial development and developing new genetic tools and resources for the scientific community.
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The Chesler Lab
Researches the genetics underlying behavior and identifies relationships among behavioral traits.
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The Churchill Lab
Investigating the genetics of health and disease with a systems approach.
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The Bloss Lab
The Bloss Lab leverages high resolution imaging, observation and manipulation of in vivo neural activity, and genetic perturbations in specific neurons to define how neural circuits…
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The Joy Lab
The Joy Lab is interested in understanding how circuits in the brain rewire after a stroke and other CNS injuries, with the goal of identifying molecular and circuit principles for…
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The Dumont Lab
Researching the mechanisms that generate genetic diversity through the lens of evolution.
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The Handel Lab
Investigates the genetic regulation of meiosis and the mechanisms of male fertility to understand how errors in meiosis can lead to developmental abnormalities.
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The Harrison Lab
Researches the genetics of aging and lifespan, seeking to understand the basic mechanisms of aging, and adult stem cells, with the goal of delaying normal aging processes.
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The Bolcun-Filas Lab
Researching meiosis, the mechanisms of DNA damage detection and repair during normal development of gametes, and implications for fertility of cancer patients after radiation …
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The Bult Lab
Bridging the digital biology divide, integrating computation with biomedical research.
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The Hinson Lab
Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders.
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The Lau Lab
Using genomic technologies and mouse modeling including patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM), we are discovering and validating novel…
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The Lee Lab
The Lee Lab studies structural genomic variation in human biology, evolution and disease.
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The Robson Lab
The Robson lab utilizes advanced molecular, cellular, and stem cell biology approaches to study evolution, development, and disease relevant to the human condition.
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The Munger Lab
Steven Munger, Ph.D., uses a systems genetics approach and advanced computational methods to study development and complex disease in advanced mouse populations.
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The Kaczorowski Lab
I lead a collaborative and interinstitutional research program that uses a multidisciplinary approach to identify early causative events underlying ‘normal’ nonpathological…
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The Kumar Lab
We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the…
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The Korstanje Lab
Studies the genetics of kidney function and disease, particularly in the context of aging.
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The Munnamalai Lab
We investigate how signaling programs instruct in vivo stem cells of the cochlea to differentiate into a highly specialized, organized sensory epithelium.
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The Li Lab
Assessing the performance of next-generation sequencing techniques in accurate genome/epigenome/transcriptome profiling and understanding the clinical and functional role of epigenome…
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The Chang Lab
The Chang Lab delves into the intricate realm of immune cell metabolism and its profound impact on diseases like cancer and lupus, forging effective treatments through in-depth…
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The Paust Lab
Members of the Paust laboratory are interested in the development and testing of novel immunotherapies that elicit clinically relevant Natural Killer cell-mediated anti-pathogen or…
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The Oh Lab
The Oh Lab studies the human microbiome for its potential to deliver treatments for infectious and other diseases. (Image by Alex Valm, NHGRI)
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The Carter Lab
Developing new computational strategies to understand complex genetic systems.
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The Rosenthal Lab
Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.
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Leadership
Nadia Rosenthal
Ph.D., FMedSci, FAAHMS
Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics, the Maxine Groffsky Endowed Chair
Meet Nadia
Charles Lee
Ph.D., FACMG
Scientific Director and Professor, The Jackson laboratory for Genomic Medicine, Robert Alvine Family Endowed Chair
Meet Charles
Voices of JAX
“I was attracted by how diverse the research programs are at JAX, beyond just cancer. I think it’s great to benefit from researchers with diverse expertise and backgrounds.”
– Assistant Professor Eric Wang, Ph.D., leukemia researcher
Latest News
Endometriosis Research at JAX
The Jackson Laboratory is working on multiple efforts related to endometriosis, including research to discovery causes and therapy targets, to increase…
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JAX hires first chief data science officer
Paul Flicek, D.Sc., joins JAX as its inaugural chief data science officer to build a global data science initiative.
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Identifying the functional mechanisms of ME/CFS
Derya Unutmaz and Julia Oh are helping to remove the obstacles for diagnosing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
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