The journalist's source for JAX related news and information
Learn how Diversity Outbred mice allow Assistant Professor Ron Korstanje, Ph.D., to zero in on the genetic factors of chronic kidney disease—a disease that costs Americans $42 billion a year.
JAX researchers say structural deterioration associated with old age can be prevented by long-term aerobic exercise starting in mid-life.
In work involving several new generations of mouse model development, Jackson Laboratory (JAX) researchers have tested a therapeutic intervention for spinal muscular atrophy (SMA) that restores some function lost due to a mutation in one gene (SMN1) and amplifies the levels of protective genes (SMN2). Moreover, unlike current interventions, the therapy appears to work after symptoms of SMA have already appeared, and may not need to be administered directly into the central nervous system.
As we age, it becomes more difficult to maintain good health, and we become more susceptible to diseases such as cancer, heart disease and stroke with each passing year. That fact seems so basic that it’s surprising that no one really understands the basic mechanisms underlying aging and why the aging process has such a large impact on wellbeing. And as researchers delve deeper into the subject, answers remain elusive.