The Beck lab uses genomics, bioinformatics and molecular biological techniques to investigate the ways in which repetitive DNA elements, such as transposons, affect human genomes.
The mechanisms governing non-recurrent human structural variation (SV) are diverse and often poorly understood. I am investigating how human DNA maintains fidelity in the context of a repetitive genome. Human Alu elements number over one million copies per human genome, and recent studies have found that these repeat sequences often mediate SVs in some loci. Through computational, molecular biological and genomic techniques, we will identify regions susceptible to this form of SV and investigate the enzymes that limit or promote Alu-mediated rearrangements. These lines of inquiry could find regions prone to instability in human cancers and lead to targets for therapy.
We take a look at the history of genomic sequencing, where it's going in the future, and the power it has to potentially treat diseases...
A research team at JAX is boosting the speed and accuracy of tumor sample image analysis, for multiple cancer types,...
I am investigating splicing-derived neo-antigens in breast and lung cancer using long-read RNA-sequencing in collaboration with the Palucka...
The Jackson Laboratory is proud to announce the 2022 recipients of the JAX Postdoctoral Scholar award. Eric Bogenschutz, Jayna Mistry, and...
Combines computational and wet lab techniques to investigate the impact of transposable elements on disease transcriptomes.
Developing tools for genome variant discovery with a focus on complex rearrangements and long-read sequencing.
Investigating the mechanisms and consequences of genomic rearrangements with a focus on repetitive elements.
Interested in the impact of structural variants and transposable elements on gene regulation
JAX researchers used long-read mRNA sequencing to catalog all mRNAs in primary breast cancer samples and revealed previously undocumented...
Investigates the impact of structural variants in diverse genomes with a focus on transposable elements in early...
A recent Cell paper uses long-read DNA sequencing and other advanced genomics tools and methods to shed light on genomic...
Roel Verhaak is leading an international group of clinicians and researchers, investigating why gliomas develop resistance and recur after...
Roel Verhaak has joined the global Cancer Grand Challenges team, receiving $25M to take on the challenge of extrachromosomal...
The new technique of methylome profiling, now available from The Jackson Laboratory, provides more precise tumor classification for cancers...