Our central goal is to investigate how our microbes contribute to our health. We seek to use diverse technologies like genomics, synthetic biology, and genome engineering to target and manipulate the microbiota for therapeutic purposes.
Dr. Oh's main research interests focus on the human microbiome—the diverse bacteria, fungi, and viruses that inhabit our bodies—for its potential to deliver treatments for infectious and other diseases. Dr. Oh comes to the microbiome world by way of fungal chemogenomics with technologist and geneticist Dr. Ronald Davis at Stanford and comparative genomics of wild wine yeast at the FAS Center for Systems Biology at Harvard. Prior to joining the Jackson Laboratory, she was a postdoctoral fellow at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health. Dr. Oh's research, exploring the complex interactions between the host and its microbes has lead to important implications for the contribution of the microbiome to disease.
More information at http://ohlabjax.weebly.com
Assistant Professor, The Jackson Laboratory for Genomic Medicine
Postdoc, National Human Genome Research Institute, National Institutes of Health
Ph.D., Stanford University
B.A., Harvard University
Oh, J., Byrd, A., Park, M., NISC Comparative Sequencing Program, Kong, H.H., Segre, J.A. Temporal stability of the human skin metagenome. Cell 2016 May;165:854–866.
Tsai, Y.C., Conlan, S., Deming, C. Segre, J.A., Kong, H.H., NISC Comparative Sequencing Program, Korlach, J., Oh, J.* Resolving the complexity of human skin metagenomes using single molecule sequencing. mBio 7(1):e01948-15. 2016. *corresponding author
Oh, J., Byrd, A., Deming, C., Conlan, S., NISC Comparative Sequencing Program, Kong, H.H., Segre, J.A. Biogeography and individuality shape function in the human skin metagenome. Nature. 514: 59–64, 2014. *with News and Views feature
Oh, J., Freeman, A.F., NISC Comparative Sequencing Program, Park, M., Sokolic, R., Candotti, F., Holland S.M., Segre, J.A., Kong, H.H. The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Research. 23:2103-2114, 2013. *featured in Nature Reviews Microbiology
Findley, K., Oh J., Yang, J., Conlan, S., Deming C., Meyer, J.A., Schoenfeld, D., Nomicos E., Park, M., NISC Comparative Sequencing Program, Kong, H.H., Segre, J.A. Topographic diversity of fungal and bacterial communities in human skin. Nature. 498(7454):367-70, 2013.
Oh, J., Segre, J.A. Genomics: Resident risks. Nature. 490:44-46, 2016.
Oh, J., Conlan, S., Polley, E., Segre, J.A., Kong, H.H. Shifts in human skin and nares microbiota of healthy children and adults. Genome Medicine 4(10): 77, 2016. *winner of BioMed Central’s Annual Microbiology, Immunology, Infection and Inflammation category Research Award
Kong, H.H., Oh, J., Deming, C., Conlan, S.P., Grice, E.A., Beatson, M.A., Nomicos, E. Polley E., Udey, M., Murray, P.R., Turner, M.L., Segre, J.A. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Research. 22(5): 850-9, 2012.