Ron Korstanje, Ph.D.
Associate Professor
Studies the genetics of kidney function and disease, particularly in the context of aging, using genetically diverse mouse models.
Chronic kidney disease (CKD) is a growing medical problem, and the number of patients progressing to end-stage renal disease has increased by 95 percent over the last 10 years in the United States. There are currently over half a million Americans on dialysis, a procedure that severely reduces quality of life and comes with much comorbidity. Furthermore, the impact of CKD is not limited to impairments related to renal failure. CKD is also recognized as an important risk factor for other ailments such as cardiovascular disease, including myocardial infarction, atherosclerosis, stroke and hypertension. A critical and unavoidable contributor to CKD is normal kidney aging.
Our goal is to identify key genetic factors that contribute to the decline of function and damage in the aging kidney, to learn their role in the kidney, and to understand why variations of these factors lead to different outcomes. We do this by studying the natural genetic variation in mice and their association with different kidney phenotypes. Once causal genes are identified, we develop precision disease models for further study of the gene and to develop therapeutics that will slow down the decline of kidney function and development of disease.
Current Grants
P30 AG038070, NIH/NIA The Jackson Laboratory Nathan Shock Center of Excellence in the Basic Biology of Aging
Role: Co-Principal Investigator and Core Leader
T32 AG062409, NIH/NIA Training Program in Precision Genetics of Aging, Alzheimer’s Disease and Related Dementias
Role: Co-Principal Investigator
RO1 ES029916, NIH/NIEHS, Genetic Factors that Influence Arsenic Toxicity
Role: Co-Principal Investigator
Alport Syndrome Foundation, Pharmaceutical Targeting of Alport Syndrome Modifier Genes.
Role: Principal Investigator
Junior Diabetes Research Foundation, Resequencing and functional analyses of two candidate genes contributing to progression to ESRD in Type 1 diabetes
Role: Co-Investigator
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Research HighlightJune 05, 2020Training the next generation of precision geneticists for aging and dementia research
Jackson Laboratory faculty have secured grant funding that will help train predoctoral students in cutting edge genetic theory and practice in the “Training Program in Precision Genetics of Aging, Alzheimer’s Disease and Related Dementias." -
Profile StoryMay 29, 2018The future of aging
University of Arizona researcher George Sutphin had never touched a mouse before he arrived as a postdoctoral associate in the Korstanje lab at The Jackson Laboratory. Now he depends on the mouse and other models as he works to develop new clinical interventions to extend healthy human lifespan and treat age-associated disease. -
Press ReleaseApril 12, 2017C. elegans reveal aging-related genes, JAX researchers report
In a paper published in Aging Cell, Jackson Laboratory Assistant Professor Ron Korstanje, Ph.D., Postdoctoral Fellow George Sutphin, Ph.D., and colleagues discovered 46 novel longevity-related genes and identified three genes that especially warrant further study. -
Research HighlightOctober 23, 2015
The transcriptional landscape of age in human blood
As we age, it becomes more difficult to maintain good health, and we become more susceptible to diseases such as cancer, heart disease and stroke with each passing year. That fact seems so basic that it’s surprising that no one really understands the basic mechanisms underlying aging and why the aging process has such a large impact on wellbeing. And as researchers delve deeper into the subject, answers remain elusive.
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Research HighlightDecember 03, 2018Hibernating bears provide clues for kidney regeneration
JAX researcher Ron Korstanje is closer to understanding exactly how bear kidneys recover from the damage caused by hibernation. -
Search MagazineMay 03, 2017Conservation and genetics
The word "conservation" has come to be associated with the environmental movement, and for good reason. For geneticists, however, conservation has an entirely different connotation. -
Search MagazineJuly 07, 2016Aerospace to Aging
It’s not rocket science — George Sutphin’s exploration of the processes underlying how and why we age is far more complicated. -
Profile StoryOctober 22, 2015A better way to find a cure for kidney disease
Learn how Diversity Outbred mice allow Assistant Professor Ron Korstanje, Ph.D., to zero in on the genetic factors of chronic kidney disease—a disease that costs Americans $42 billion a year.
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Bearing down on kidney disease at The Jackson Laboratory
Ron Korstanje, Ph.D., is researching the nephrons of mice, zebrafish, and black bears, in order to find new ways to treat kidney damage and disease. -
UNE Keynote
The UNE Keynote address by Ron Korstanje.
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Selena Neptune-Bear
Selena Neptune-Bear, JAX Summer Student Class of 2017