Conducting research to elucidate and compare the transcriptional network structure and dynamics driving organogenesis.
It has become clear that genetic background, including both common and rare variants, significantly influences disease susceptibility, severity, prognosis and even treatment effectiveness. Most genetic variants assert subtle effects in isolation, but certain combinations can disrupt normal homeostasis and sensitize an individual to disorder. Thus, many complex diseases have resisted classification by single-gene experimental and/or statistical modeling approaches. A comprehensive characterization of the genetic etiology of complex disorders and disease must account for the effects of all inputs (e.g. genetic variation) on all outputs (e.g. transcription, measures of structure/function) in the context of the affected system.
My overarching research goals are to 1) characterize the transcriptional network architecture underlying normal organ development and homeostasis, 2) predict the genes, gene-gene interactions, and coregulated gene cohorts with major roles in this process, and 3) identify and validate genetic mutations with individual small effects that together disrupt the buffering capacity of the transcriptional network and cause a disordered/disease state. To that end, I take a systems genetics approach that integrates advanced computational methods and experimental validation techniques to next-generation genetic mapping populations, including the mouse Collaborative Cross and Diversity Outcross, to elucidate and compare the transcriptional network structure and dynamics driving organogenesis (the embryonic gonad at the critical time point of primary sex determination) and adult tissue homeostasis (liver).
2015-2017 term - Elected to Secretariat of the International Mammalian Genome Society
2013-2015 - Ruth L. Kirschstein National Research Service Award, Individual postdoctoral fellowship
2013 - Chicago Prize for Outstanding Oral Presentation, 12th Annual Meeting of the Complex Trait Community
2012 - Best Oral Presentation by a Post-Doctoral Fellow, 11th Annual Meeting of the Complex Trait Community
2011 - Verne Chapman Memorial Young Scientist Award, International Mammalian Genome Society
2008 - Best Oral Presentation by a Graduate Student, 7th Annual Meeting of the Complex Trait Consortium
2004-2006 - NIH Predoctoral Training Grant, Institution-awarded fellowship
Chick JM*, Munger SC*, Simecek P, Huttlin EL, Choi KB, Gatti DM, Raghupathy N, Svenson KL, Churchill GA§, and Gygi SP§. Defining the consequences of genetic variation on a proteome-wide scale. Nature. 2016, In Press.
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