J. Travis Hinson, M.D., utilizes genomic approaches like CRISPR/CAS to interrogate mechanisms of inherited cardiovascular disorders especially those that lead to heart failure. He is particularly interested in developing single cell and cardiac microtissue assays derived from disease-specific, human induced pluripotent stem cells (iPScs) in combination with in vivo mouse models. His lab’s current research focus is:
To define the role of AMP-activated protein kinase in physiologic and pathologic forms of cardiac remodeling.
To engineer cardiac microtissues to study the most common forms of familial hypertrophic and dilated cardiomyopathies due to sarcomere mutations.
To develop assays for high-throughput functional genomic screens to predict pathogenicity of genetic variation in cardiomyopathy genes.
These studies capitalize on the Laboratory’s expertise in human genetics, stem cell biology, tissue engineering and computational methods. While my laboratory is at the Jackson Lababoratory, I also maintain a clinical practice treating patients with inherited cardiovascular diseases at the University of Connecticut Cardiology division.
Travis Hinson, M.D., has received more than $2 million from the National Institutes of Health National Heart, Lung, and Blood Institute to study the mechanisms responsible for a serious and often fatal heart condition.
Dr. Travis Hinson, a joint faculty member at The Jackson Laboratory and UConn Health, discusses his work in cardiovascular genetics as both a physician and a scientist to advance translational medicine and enhance patient outcomes for heart diseases including cardiomyopathy and heart failure.
A team led by researchers at Boston University and Harvard University, and including JAX Assistant Professor Travis Hinson, M.D., used a newly developed model system, cultured human cardiomyocytes derived from induced pluripotent stem cells (iPSCs), to study the role of titin and other aspects of sarcomere assembly.
In a paper published in Cell Reports, a team of researchers including JAX Assistant Professor Travis Hinson, M.D., report how they used human cell lines in addition to an animal model to study the mechanisms of the PRKAG2 mutation.
Dr. Travis Hinson, a joint faculty member at The Jackson Laboratory and UConn Health, discusses his work in cardiovascular genetics as both...