J. Travis Hinson, M.D.
Assistant Professor
Utilizes genomic approaches like CRISPR/CAS to interrogate mechanisms of inherited cardiovascular disorders especially those that lead to heart failure.
J. Travis Hinson, M.D., utilizes genomic approaches like CRISPR/CAS to interrogate mechanisms of inherited cardiovascular disorders especially those that lead to heart failure. He is particularly interested in developing single cell and cardiac microtissue assays derived from disease-specific, human induced pluripotent stem cells (iPScs) in combination with in vivo mouse models. His lab’s current research focus is:
- To define the role of AMP-activated protein kinase in physiologic and pathologic forms of cardiac remodeling.
- To engineer cardiac microtissues to study the most common forms of familial hypertrophic and dilated cardiomyopathies due to sarcomere mutations.
- To develop assays for high-throughput functional genomic screens to predict pathogenicity of genetic variation in cardiomyopathy genes.
These studies capitalize on the Laboratory’s expertise in human genetics, stem cell biology, tissue engineering and computational methods. While my laboratory is at the Jackson Lababoratory, I also maintain a clinical practice treating patients with inherited cardiovascular diseases at the University of Connecticut Cardiology division.
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Research HighlightAugust 30, 2023Global collaboration powers understanding of muscle development
With support from the Human Frontier Science Program, J. Travis Hinson aims to determine the fundamental biophysical and structural principles that form the sarcomere during biogenesis. -
Research HighlightMay 21, 2021Unlocking our heart’s capacity to regenerate
Assistant Professor J. Travis Hinson, M.D., is using the latest cellular technologies to engineer human cells to investigate the molecular mechanisms preventing human heart regeneration. -
Research HighlightJanuary 22, 2018Assembly required: New insight into cardiac cell development
A team led by researchers at Boston University and Harvard University, and including JAX Assistant Professor Travis Hinson, M.D., used a newly developed model system, cultured human cardiomyocytes derived from induced pluripotent stem cells (iPSCs), to study the role of titin and other aspects of sarcomere assembly. -
Research HighlightJanuary 05, 2017Identifying a pattern of metabolic remodeling in the heart
In a paper published in Cell Reports, a team of researchers including JAX Assistant Professor Travis Hinson, M.D., report how they used human cell lines in addition to an animal model to study the mechanisms of the PRKAG2 mutation.
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Research HighlightAugust 10, 2021New actinin research focuses on the heart
In a paper published in Cell Reports, a team including JAX assistant professor Travis Hinson, M.D, present a detailed portrait of one of actinin’s interprotein interactions and provide a compendium of proteins that could be the focus of further study. -
Press ReleaseAugust 01, 2018
$2M NIH Grant to Study Genetic Mechanisms of Inherited Heart Muscle Disorders
Travis Hinson, M.D., has received more than $2 million from the National Institutes of Health National Heart, Lung, and Blood Institute to study the mechanisms responsible for a serious and often fatal heart condition. -
Search MagazineFebruary 15, 2017Your family could benefit from cardiovascular genetic testing
Patients who know they have a genetic predisposition to heart disease can take extra precautions and alert their health care providers to try to prevent symptoms before they occur. -
Blog PostAugust 26, 2016At the heart of clinical genetics
Travis Hinson, M.D. discusses what his joint appointment with UConn Health and JAX means for his research into the genomic basis of cardiovascular disorders.