The Joy Lab is interested in understanding how circuits in the brain rewire after a stroke and other CNS injuries, with the goal of identifying molecular and circuit principles for recovery.
Stroke causes death of brain tissue leading to long-term motor and cognitive deficits, making it the leading cause of serious-long term disability. With the loss of brain regions after a stroke, surviving circuits rewire and attempt to adapt to this loss. There is little understanding on fundamental mechanisms of how circuits rewire and the consequence of these rewiring processes on brain function. The focus of the Joy lab is to understand mechanisms of circuit reorganization, identify maladaptive and adaptive processes and determine how these processes change the way the brain encodes motor and cognitive functions. Our investigations span synaptic, molecular, circuit and behavioral domains to identify circuit mechanisms and molecular signatures that drive recovery and identify therapeutic targets for stroke. We are also interested in translating these findings to other disease models of CNS injuries. We use a host of techniques including but not limited to large-scale mesoscopic calcium imaging, widefield imaging, optogenetics, transcriptomics, gene/protein targeting with viral vectors or drugs and ethological measurements of behavior.
In MODEL-AD we are working to build new Late-onset Alzheimer's mouse models that are available to the scientific community.
Interested in studying regeneration and functional connectivity in the brain after an ischemic stroke and developing methods to improve...
Administrative support to research faculty and their lab personnel
With support from the Human Frontier Science Program, J. Travis Hinson aims to determine the fundamental biophysical and structural...
We invite you to join us for an immersion workshop focusing on the improvement of preclinical translation in Alzheimer’s Disease research....
This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the...
During this one-of-a-kind workshop on mouse stereotaxic surgery, participants will learn how to: use different types of stereotaxic...
This is a four-day, professional development course geared towards senior graduate students and postdoctoral fellows, which will help you...