Bar Harbor, ME
Bridges the digital biology divide, by integrating computation and informatics with biomedical research.Visit The Bult Lab
The primary theme of my personal research program is “bridging the digital biology divide,” reflecting the critical role that informatics and computational biology play in modern biomedical research. I am a Principal Investigator in the Mouse Genome Informatics (MGI) consortium that develops knowledgebases to advance the laboratory mouse as a model system for research into the genetic and genomic basis of human biology and disease (http://www.informatics.jax.org). Recent research initiatives in my research group include computational prediction of gene function in the mouse and the use of the mouse to understand genetic pathways in normal lung development and disease.
My institutional responsibilities at The Jackson Laboratory include serving as the Deputy Director of the Cancer Center and as the Scientific Director of our Patient Derived Xenograft (PDX) and Cancer Avatar program. The PDX program is a resource of deeply characterized and well-annotated "human in mouse" cancer models with a focus on bladder, lung, colon, breast and pediatric cancer. This resource is a powerful platform for research into basic cancer biology (such as tumor heterogeneity and evolution) as well as for translational research into mechanisms of therapy resistance and therapeutic strategies to overcome resistance.
August 2013 - Jackson Laboratory National Council Award for Scientific Achievement
May 2013 - Jackson Laboratory Community Award
March 2011 - Roy H. Behnke Distinguished Lecturer, University of South Florida
June 8, 1998 - Bult et al., 1996. Science 273:1058 cited as a "Hot Paper in Genetics" by The Scientist
1997 - "Hottest Research of 1996" (based on numbers of literature citations), The Institute for Scientific Information (ISI)
1997 - Carl Von Linneaus Lecturer, Uppsala University, Uppsala, Sweden
1996 - Discover magazine top 100 science stories for 1996
1994 - National Science Foundation Travel Grant recipient to attend the 6th Congreso Latino Americano de Botanica, Mar del Plata, Argentina
1993-1996 - Appointed an honorary Research Associate at the Smithsonian Institution, Laboratory of Molecular Systematics, Washington, D.C.
1989 - Elected full member of the Sigma Xi Research Honor Society
1989 - Awarded full tuition to attend the Sloan Foundation sponsored "Workshop on Molecular Evolution."
1989 - UNH Women's Commission Award for "significant contributions to the advancement of women in the sciences at UNH"
1988 - UNH Dissertation Fellowship Award
1984 - Faculty Award for "Outstanding Senior in Biology," GMU
1984 - Elected to the Beta Beta Beta Biological Honor Society
Ananda G, Mockus S, Lundquist M, Spotlow V, Simons A, Mitchell T, Stafford G, Philip V, Stearns T, Srivastava A, Barter M, Rowe L, Malcolm J, Bult C, Karuturi RK, Rasmussen K, Hinerfeld D. Development and validation of the JAX Cancer Treatment Profile™ for detection of clinically actionable mutations in solid tumors. Exp Mol Pathol. 2015 Feb;98(1):106-12.
Bult CJ, Krupke DM, Begley DA, Richardson JE, Neuhauser SB, Sundberg JP, Eppig JT. Mouse Tumor Biology (MTB): a database of mouse models for human cancer. Nucleic Acids Res. 2015 Jan;43(Database issue):D818-24.
Eppig JT, Blake JA, Bult CJ, Kadin JA, Richardson JE; Mouse Genome Database Group. The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease. Nucleic Acids Res. 2015 Jan;43(Database issue):D726-36.
The MGD provides free access to a wealth of genetic, genomic and biological data to the worldwide biomedical research community, and is a critical resource for advancing the emerging field of precision genomic medicine.
As part of a comprehensive relationship to advance cancer research and accelerate personalized genomic medicine, The Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) and The Jackson Laboratory (JAX) have launched seven joint research projects to study a variety of cancer types, including multiple myeloma, lung, breast, prostate and brain cancers. The projects bring together 28 scientists – 14 from each institution – to lead investigations ranging from basic science to the development of clinical therapies.
New research from the University of California Davis and The Jackson Laboratory provides more evidence that patient-derived xenografts (PDXs), human tissues implanted in immunocompromised mice, can provide powerful insight into cancer mechanisms and therapies.
Professor Carol Bult, Ph.D., investigates relationships between genes, cancer, pain and other health issues.
It's time to update the old “bench-to-bedside” shorthand, researchers at JAX, NHGRI and institutions across the U.S. declare.
Last week, leaders from multinational pharmaceutical and biotechnology companies, major academic cancer centers, health insurance companies, and other key players, announced the launch of Cancer Moonshot 2020. The program’s sole purpose: accelerating the potential of combination immunotherapies as the next generation standard of care in patients with cancer.
Jackson Laboratory (JAX) cancer researcher Carol Bult, Ph.D., has been appointed to the Knowlton Family Chair, an endowed professorship newly established by Winthrop Knowlton, chairman emeritus of the Laboratory’s board of trustees.
The Jackson Laboratory is launching a two-year, statewide “virtual clinical trial” with $212,000 in grant funding from the Maine Cancer Foundation, with the goal of finding effective drug treatments for triple-negative breast cancer patients.
The NOD scid gamma mouse uniquely supports the engraftment of human hematopoietic cells, enabling the creation of “humanized” NSG™...
Advance your research in genetics by harnessing the power of the mouse! This new graduate-level advanced genetics course will provide a...
Join this webinar to learn about cutting edge preclinical mouse platforms used to evaluate immuno-modulatory therapies for...
This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the...
New collaboration expands access to leading-edge research capabilities to find new treatments for life-threatening diseases.
Kevin Johnson, Ph.D., a postdoc in the Verhaak lab, recently received the prestigious American Cancer Society Postdoctoral...
A JAX-led research team detects gene expression patterns distinct from those of the surrounding immune cells, and characterizes the effects...
Establishing PDX cohorts from frozen samples can extend drug efficacy studies 6-12 weeks or more. The inventoried PDX Live tumor program at...
We are committed to providing academic PIs the most innovative pre-clinical models and services to delineate the mechanisms underlying...
We provide access to many bladder cancer PDX models, including muscle-invasive options. Models are currently available for efficacy testing...
We provide access to several different AML PDX models currently available in the highly immunodeficient NSG-SGM3 mouse strain, which...
Over 20 unique breast cancer PDX models are currently available within our PDX model cancer collection, including the most common and...
Our PDX collection has over 50 unique lung cancer PDX models representing a diverse set of clinically relevant mutations currently observed...
We provide access to a large collection of ovarian PDX models currently available for efficacy testing at our facility or for distribution...
We provide access to a large collection of pancreatic cancer PDX models currently available for efficacy testing at our facility or for...
The Jackson Laboratory has played a critical role in cancer and genetic research since 1929.