We are interested in targeting circuits in the brain for repair in neurological diseases such as stroke. With intersectional tools that employ large-scale recordings of neural activity, quantitative measurements of motor control and transcriptomics, we hope to determine how circuits that control motor actions reorganize in disease and use molecular information to identify therapeutic targets.
I received my PhD in Neuroscience from University College London (UCL) where I trained with Dr. Patrick Anderson. My work focused on understanding molecular mechanisms that can be targeted for axonal regeneration in the injured spinal cord. Towards the end of my PhD, I became interested in projections upstream of the spinal cord, in the brain, where connections are more plastic. To further my understanding in reparative mechanisms in the brain, I undertook postdoctoral training with Dr. S.Thomas Carmichael at UCLA, where I studied molecular mechanisms that underlie plasticity during learning and memory as targets for stroke. In addition to molecular targets, I became interested in how neural circuits interact during movement, a domain that is compromised in stroke patients. For further training, I was awarded a visiting fellowship at Janelia, HHMI, where I worked with Dr. Adam Hantman, where I used a unique imaging platform to visualize and target circuit activity across multiple regions in the brain to determine how motor information is encoded in real-time in the normal brain. In my current lab, using a combination of techniques, we will determine how circuits re-organize after a stroke, how these re-organizational processes contribute to changes in motor function, molecular mechanisms that enhance plasticity in these circuits and therapeutic targets that can be clinically translated.