The Shuzhao Li Lab
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins.
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins. This revolutionary information fills a major gap between genome and environment, with broad applications to diseases and precision medicine. We combine experimental approaches with computational algorithms that identify pathway patterns and integrate chemical reactions and biology.
Current projects:
- Probabilistic metabolite and network models for metabolomics. This includes the Mummichog Project, and addresses challenges in the assembly of information in metabolomics.
- Reconstruction of biochemical networks and application to immunometabolism. The goal is to upgrade genome scale metabolic models by mass spectrometry data, via a combination of computational, genetic, cellular and isotope tracing techniques.
- Multi-omics, multiscale modeling of human immunology. We are generating lakes of data from vaccine studies. Coupled with large-scale data mining and new generation of artificial intelligence, the resulting models shall aid vaccine development, immunotherapy and the fight against many diseases.
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Research HighlightApril 20, 2022Fibroblasts may hold the keys to regeneration
New research from JAX indicates that fibroblasts may hold the ability to jump start human tissue repair and regeneration capabilities. -
Research HighlightDecember 13, 2021Examining the immune response to cancer on a genetic level
The V Foundation for Cancer Research has awarded a grant to JAX's Lucas Chang for genetic studies of the immune response to cancer. -
Research HighlightNovember 19, 2021Exploring the functional genetic diversity of wild mice
Researchers are working to broaden the genetic diversity of mice used in biomedical research. -
Press ReleaseOctober 21, 2021JAX Ellsworth welcomes its 125th employee
The Jackson Laboratory has hired its 125th employee at the Charles E. Hewett Center in Ellsworth. The Center opened just three years ago to enable wider access to vital JAX mouse resources for the worldwide biomedical research community.
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Featured ArticleApril 05, 2022Making sense of the universe in three dimensions
glue solutions inc., a firm specializing in data science and visualization, grew out of a project to visualize astronomy data and is now working with JAX to do the same for genomics, providing ways to bring the genetic data to life. -
Blog PostDecember 09, 2021Studying CRS in a Diverse Population
To understand the future of these preclinical studies, we sat down with James Keck, Ph.D., who was recently recognized as a JAX President’s Innovation Fellow for his work creating mouse-based platforms to study the immune system, and evaluate new therapeutics for both safety and efficacy. -
Tech CornerNovember 19, 2021100,000 Genomes Project: Applying genome sequencing to rare disease diagnoses
Findings from a new pilot study published in the New England Journal of Medicine support the case for using whole-genome sequencing for diagnosing rare disease patients. -
Press ReleaseSeptember 23, 2021Innovation awarded to a ‘scientist’s scientist’
James Keck has been recognized as JAX President’s Innovation Fellow for inventions to accelerate drug development.