The Li Lab
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins.
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins. This revolutionary information fills a major gap between genome and environment, with broad applications to diseases and precision medicine. We combine experimental approaches with computational algorithms that identify pathway patterns and integrate chemical reactions and biology.
Current projects:
- Probabilistic metabolite and network models for metabolomics. This includes the Mummichog Project, and addresses challenges in the assembly of information in metabolomics.
- Reconstruction of biochemical networks and application to immunometabolism. The goal is to upgrade genome scale metabolic models by mass spectrometry data, via a combination of computational, genetic, cellular and isotope tracing techniques.
- Multi-omics, multiscale modeling of human immunology. We are generating lakes of data from vaccine studies. Coupled with large-scale data mining and new generation of artificial intelligence, the resulting models shall aid vaccine development, immunotherapy and the fight against many diseases.
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Featured ArticleOctober 13, 2022Retraining the immune system to fight against cancer
With a new tactic in immunotherapy, Derya Unutmaz and his team has successfully engineered an atypical type of immune cell, the human mucosal-associated T cell, with the capabilities to overcome challenges in standard CAR-T cell treatment. -
Research HighlightSeptember 08, 2022Measuring frailty in mice to examine aging
Vivek Kumar is using machine learning and computational science to examine frailty in mice to study the biology of aging. -
Press ReleaseAugust 31, 2022Peter Robinson to serve on NHGRI Advisory Council
Peter Robinson of the Jackson Laboratory was sworn in to the National Human Genome Research Institute’s (NHGRI) Advisory Council on Aug 19, 2022. -
Featured ArticleApril 05, 2022Making sense of the universe in three dimensions
glue solutions inc., a firm specializing in data science and visualization, grew out of a project to visualize astronomy data and is now working with JAX to do the same for genomics, providing ways to bring the genetic data to life.
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Research HighlightOctober 04, 2022Defining lung cancer
Carol Bult is leading a team that has laid the groundwork for advancements in non-small cell lung cancer research using patient derived xenograft (PDX) mice. -
Featured ArticleSeptember 06, 2022Developing machine learning and deep learning at JAX
Matthew Gerring is applying the machine learning and deep learning revolution at JAX. -
Research HighlightApril 20, 2022Fibroblasts may hold the keys to regeneration
New research from JAX indicates that fibroblasts may hold the ability to jump start human tissue repair and regeneration capabilities. -
Research HighlightDecember 13, 2021Examining the immune response to cancer on a genetic level
The V Foundation for Cancer Research has awarded a grant to JAX's Lucas Chang for genetic studies of the immune response to cancer.