The Shuzhao Li Lab
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins.
The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins. This revolutionary information fills a major gap between genome and environment, with broad applications to diseases and precision medicine. We combine experimental approaches with computational algorithms that identify pathway patterns and integrate chemical reactions and biology.
Current projects:
- Probabilistic metabolite and network models for metabolomics. This includes the Mummichog Project, and addresses challenges in the assembly of information in metabolomics.
- Reconstruction of biochemical networks and application to immunometabolism. The goal is to upgrade genome scale metabolic models by mass spectrometry data, via a combination of computational, genetic, cellular and isotope tracing techniques.
- Multi-omics, multiscale modeling of human immunology. We are generating lakes of data from vaccine studies. Coupled with large-scale data mining and new generation of artificial intelligence, the resulting models shall aid vaccine development, immunotherapy and the fight against many diseases.
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Press ReleaseOctober 21, 2021JAX Ellsworth welcomes its 125th employee
The Jackson Laboratory has hired its 125th employee at the Charles E. Hewett Center in Ellsworth. The Center opened just three years ago to enable wider access to vital JAX mouse resources for the worldwide biomedical research community. -
Research HighlightSeptember 20, 2021Variable COVID-19 pathology depends on host genetic backgrounds
Mice with different genetic backgrounds exhibit highly variable responses to SARS-CoV-2 infection, mirroring the large differences in COVID-19 disease severity seen in humans. -
Search MagazineSeptember 08, 2021Aging and immune function: a weakening line of defense
Why do we become ever more susceptible to various diseases over time? And do we all age in the same way, or are there differences? -
Research HighlightJuly 20, 2021Finding splice variants of clinical importance with SQUIRLS
Professor Peter Robinson, M.D., MSc., and Associate Computational Scientist Daniel Danis, Ph.D., used machine learning and datasets of splice variants associated with Mendelian (single-gene, inherited) disorders to develop a new algorithm to develop a new algorithm to improve clinical diagnostics.
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Press ReleaseSeptember 23, 2021Innovation awarded to a ‘scientist’s scientist’
James Keck has been recognized as JAX President’s Innovation Fellow for inventions to accelerate drug development. -
Featured ArticleSeptember 09, 2021Programming CKB: bringing clinical expertise to the world
Dan Durkin, technical team lead on the Clinical Knowledgebase (CKB), gives a first hand explanation of this powerful tool (available to anyone) that allows clinicians and researchers to better interpret complex cancer genomic profiles. -
Search MagazineSeptember 08, 2021How can we win the battle against late-onset Alzheimer's disease?
The need to find an effective therapy or preventative treatment for Alzheimer's disease is growing. -
Press ReleaseJune 21, 2021JAX center helps develop new genomic technology
JAX and principal investigator Mark Adams were chosen by the National Human Genome Research Institute to form the Technology Development Coordinating Center. The center will help accelerate genomics research through focused coordination and outreach programs.