The genetic origins of most developmental disorders and diseases are complex and remain poorly understood. Rather than a single deleterious mutation, genetic susceptibility to common diseases is conferred by many variants that individually assert subtle effects but in certain combinations perturb cellular networks sufficiently to bias them to a disordered/diseased state. Classic single-gene experimental approaches fail to elucidate these interactions, but new integrative genomic and genetic approaches from the emerging field of “Systems Genetics” hold considerable promise.
The Munger lab combines experimental and computational methods with advanced mouse mapping populations to solve these complex genetic puzzles.
We examine the natural genetic variation driving individual differences in 1) susceptibility to sex reversal during primary sex determination of the gonad, 2) disease severity in a mouse model of Cornelia de Lange Syndrome, and 3) transcript and protein expression in the adult liver. We apply our genetic and genomics toolkit to predict causal variants and genetic interactions underlying phenotypic variability, validate these predictions at the bench with functional genomics methods, and ultimately seek to extend these results to inform patient diagnosis and treatment.
Chick JM*, Munger SC*, Simecek P, Huttlin EL, Choi KB, Gatti DM, Raghupathy N, Svenson KL, Churchill GA§, and Gygi SP§. Defining the consequences of genetic variation on a proteome-wide scale. Nature. 2016, In Press.
My primary areas of interest are software engineering, bioinformatics, and genomics.
The Jackson Laboratory has appointed Steven Munger, Ph.D., to its research faculty as an assistant professor, after three...
Comparing mutagenesis techniques to probe the logic underlying cis-regulatory elements.
A research team led by Albert Cheng developed a new method, CASFx, that leverages CRISPR technology to alter messenger RNA...
Assistant Professor Steve Munger’s long road to embracing research has led to a life of open-ended questions.
Conducting research to elucidate and compare the transcriptional network structure and dynamics driving organogenesis.
The Maine Cancer Genomics Initiative at The Jackson Laboratory is pleased to offer a special virtual event on genomic tumor...
The health of mouse models can impact the timelines of research studies and interpretation of experimental results. During this...
Research into lung development and role of miRNAs to better understand cancer, other lung diseases.
Develops and enhances the Gene Expression Database (GXD), which captures, integrates and displays mouse developmental expression data...
High Throughput Image analysis of histological data.
This poster is a great resource for accurately aging mouse pups of various coat colors.
This double sided laminated poster allows you to quickly and easily identify your mice by visual examination of the external...
My research interest lie at the intersection of genetic diversity and environmental variability, with the goal of elucidating how GxE...
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