Steven Munger, Ph.D., uses a systems genetics approach and advanced computational methods to study development and complex disease in advanced mouse populations.
The genetic origins of most developmental disorders and diseases are complex and remain poorly understood. Rather than a single deleterious mutation, genetic susceptibility to common diseases is conferred by many variants that individually assert subtle effects but in certain combinations perturb cellular networks sufficiently to bias them to a disordered/diseased state. Classic single-gene experimental approaches fail to elucidate these interactions, but new integrative genomic and genetic approaches from the emerging field of “Systems Genetics” hold considerable promise.
The Munger lab combines experimental and computational methods with advanced mouse mapping populations to solve these complex genetic puzzles.
We examine the natural genetic variation driving individual differences in 1) susceptibility to sex reversal during primary sex determination of the gonad, 2) disease severity in a mouse model of Cornelia de Lange Syndrome, and 3) transcript and protein expression in the adult liver. We apply our genetic and genomics toolkit to predict causal variants and genetic interactions underlying phenotypic variability, validate these predictions at the bench with functional genomics methods, and ultimately seek to extend these results to inform patient diagnosis and treatment.
Chick JM*, Munger SC*, Simecek P, Huttlin EL, Choi KB, Gatti DM, Raghupathy N, Svenson KL, Churchill GA§, and Gygi SP§. Defining the consequences of genetic variation on a proteome-wide scale. Nature. 2016, In Press.
Munger SC, Natarajan A, Looger LL, Ohler U, Capel B. Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. PLoS Genet. 2013;9(7):e1003630.
Musser MA, Munger SC, Gunn TM. Meeting report of the 26th International Mammalian Genome Conference. Mamm Genome. 2013 Jun;24(5-6):179-89.
Munger SC, Raghupathy N, Choi K, Simons AK, Gatti DM, Hinerfeld DA, Svenson KL, Keller MP, Attie AD, Hibbs MA, Graber JH, Chesler EJ, Churchill GA. RNA-Seq alignment to individualized genomes improves transcript abundance estimates in multiparent populations. Genetics. 2014 Sep;198(1):59-73.
My studies focus on evolution and function implications of structural variations in human population.
Sabriya studies how genomic and epigenomic factors impact chromatin organization.
The Jackson Laboratory has appointed Steven Munger, Ph.D., to its research faculty as an assistant professor, after three...
Bioinformatics, Cloud/High Performance Computing, Pipeline Development, Microbiome, Cancer biology, Precision Medicine, Genetics, and...
I develop tools to describe the phenotypic features of neurodevelopmental disorders and discover their associated genotypes.
Assistant Professor Steve Munger’s long road to embracing research has led to a life of open-ended questions.
My research interest combines genetic diversity with human disease presentation, prevention, and treatment.
Conducting research to elucidate and compare the transcriptional network structure and dynamics driving organogenesis.
Develops and enhances the Gene Expression Database (GXD), which captures, integrates and displays mouse developmental expression data...
I use image processing and shape quantification methods to extract information from imaging data and link them to phenotypes by machine...
Research into lung development and role of miRNAs to better understand cancer, other lung diseases.
This poster is a great resource for accurately aging mouse pups of various coat colors.
This double sided laminated poster allows you to quickly and easily identify your mice by visual examination of the external...
I am currently working on developing a panel of genetically diverse mouse embryonic stem cell lines for use in future...
My research interest lie at the intersection of genetic diversity and environmental variability, with the goal of elucidating how GxE...
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