The Dumont Lab
Researching the mechanisms that generate genetic diversity through the lens of evolution
Principal Investigator
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Our Research Focus
The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.
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Search MagazineOctober 26, 2021Reshaping brain cells for Alzheimer's study
By isolating and reprogramming brain cells with dementia-causing genetic mutations, a team at JAX offers a powerful new research tool. -
Research HighlightOctober 06, 2021Exploring the complex regulation of protein abundance
Using advanced mouse populations and newly developed research protocols for measuring proteins, JAX researchers are exploring how proteome is regulated, why it varies on individual genetics, and how consistent this is across different populations. -
Research HighlightSeptember 22, 2021JAX is tracking sub-genomic SARS-CoV-2 variation
Chia-Lin Wei looked at SARS-CoV-2 RNA genomes and sub-genomic viral RNA in symptomatic and asymptomatic patients and found distinct, consistent differences between the patient groups. The findings have important implications for developing better COVID-19 risk mitigation and clinical strategies. -
Featured ArticleSeptember 09, 2021Programming CKB: bringing clinical expertise to the world
Dan Durkin, technical team lead on the Clinical Knowledgebase (CKB), gives a first hand explanation of this powerful tool (available to anyone) that allows clinicians and researchers to better interpret complex cancer genomic profiles.
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Blog PostOctober 25, 2021Assessing patient health risks with limited or unknown family history
With November designated as Family Health History month, clinicians are sure to have seen lots of messaging encouraging their patients to discuss family health history around the Thanksgiving table. But what if there is no family history to be gathered? -
Press ReleaseSeptember 30, 2021Genomic Innovator Award to JAX's Ryan Tewhey
Special 5-year, $2.5M National Human Genome Research Institute grant funds “highly innovative work” by early-career scientists. -
Featured ArticleSeptember 21, 2021Hartford Business Journal honors Albert Cheng
Assistant Professor at The Jackson Laboratory for Genomic Medicine, Albert Cheng, receives award from the Hartford Business Journal -
Search MagazineSeptember 08, 2021How can we win the battle against late-onset Alzheimer's disease?
The need to find an effective therapy or preventative treatment for Alzheimer's disease is growing.