Researching the mechanisms that generate genetic diversity through the lens of evolution
The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.
Researching the mechanisms that generate genetic diversity through the lens of evolution
To study the evolution of genes related to fertility and sexual reproduction, and to use this information to understand infertility in...
This hands-on workshop teaches participants to make and manipulate mouse embryos to generate new genetic models and efficiently manage...
Interested in genetic diversity and evolution of wild and wild-derived mice
Unraveling the evolutionary forces that give rise to the observed genetic diversity in the house mouse
Developing new computational strategies to understand complex genetic systems.
Developing novel CRISPR protocols to isolate and sequence recalcitrant regions of the genome
Investigating the composition and diversity of centromeric sequence amongst Mus musculus subspecies and autosomes vs sex chromosomes to...
Conducting research to elucidate and compare the transcriptional network structure and dynamics driving organogenesis.
The JAX Scholar award offers exceptional early-career scientists the opportunity to develop their independent research program at The...
Machine learning platforms can be fed data to "teach" them to learn patterns and predict outcomes, and they are becoming...
This JAX short course brings together world-renowned experts in addiction, human genetics, and mouse genetics. Through a combination of...
For many, testing provides a window into their innermost self, their genome, and a new way to learn about themselves.
My work utilizes a combination of high-performance parallel and distributed computing resources, machine learning, and algorithm...
Discoveries in JAX-founded Collaborative Cross, Diversity Outbred populations show value of multi-parent model organism...
Maintaining experimental mouse colonies is a lot like juggling. There are a lot of balls that you have to keep in the air all the time. You...
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