The Dumont Lab
Researching the mechanisms that generate genetic diversity through the lens of evolution
Principal Investigator
Location
Topics
Our Research Focus
The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.
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Research HighlightSeptember 28, 2022Tipping the scale toward favorable outcomes in cancer and beyond
Jennifer Trowbridge and her team reveal the molecular signaling pathway most associated with clonal hematopoiesis and how blocking a specific cell-surface receptor in the pathway can tip the balance toward positive health outcomes. -
Research HighlightSeptember 08, 2022Measuring frailty in mice to examine aging
Vivek Kumar is using machine learning and computational science to examine frailty in mice to study the biology of aging. -
Featured ArticleSeptember 06, 2022Connecting life-long dietary restrictions and loss of cognitive function
Andrew Ouellette is helping to discover new connections between life-long dietary restriction and the loss of cognitive function. -
Blog PostJuly 26, 2022Postbacc fellows at JAX preparing for MD PhDs
In 2017 JAX Genomic Education expanded to include recent college graduates in our new Postbaccalaureate Fellows Program. Let's meet six current 2022 Fellows.
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Featured ArticleSeptember 15, 2022JAX undertakes nationwide study to evaluate impact of genomic tumor boards on cancer care
The Jackson Laboratory announced today that it will take its cornerstone genomic tumor board program to oncologists across the nation as part of a SWOG Cancer Research Network study, in collaboration with Columbia University. -
Featured ArticleSeptember 06, 2022Developing machine learning and deep learning at JAX
Matthew Gerring is applying the machine learning and deep learning revolution at JAX. -
Press ReleaseAugust 31, 2022Peter Robinson to serve on NHGRI Advisory Council
Peter Robinson of the Jackson Laboratory was sworn in to the National Human Genome Research Institute’s (NHGRI) Advisory Council on Aug 19, 2022. -
Research HighlightJuly 21, 2022Investigating endometriosis, cell by cell
Many women worldwide are affected by endometriosis, though there has been relatively little research into causes or possible therapies. Elise Courtois, associate director of the Single Cell Biology group at The Jackson Laboratory, is a leading proponent for increasing awareness of and funding for endometriosis.