Jackson Laboratory

The Dumont Lab

Principal Investigator: Beth Dumont, Ph.D.

The Jackson Laboratory
Bar Harbor, ME

Contact me at: 207-288-6647

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Researching the mechanisms that generate genetic diversity through the lens of evolution

Our Research Focus

The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.

Full Scientific Report

Research HighlightNovember 08, 2018
Working with uncertainty in cell populations
JAX researchers have developed a new computational algorithm that is capable of modeling the effects of both stochastic gene expression and cell-to-cell variability in a cell population.
Press ReleaseOctober 24, 2018
Data provides new hope for pediatric brain tumor patients
Using computer models, researchers have identified a potential new therapy that would reduce the long-term side effects of radiation therapy in pediatric brain cancer patients.
Search MagazineOctober 09, 2018
Of mighty mice and men
Pioneering scientist Se-Jin Lee, a leader in the study of muscle development, moves his groundbreaking research program to JAX.
Press ReleaseOctober 02, 2018
Addiction: The microbiome link
The National Institute on Drug Abuse has made a $4M grant to JAX scientists to explore the roles of the microbiome and genetics in substance use disorders.

Blog PostOctober 31, 2018
Can we do a better job of preserving fertility and ovarian function for young breast cancer survivors?
Young women with a new cancer diagnosis are faced with a number of challenges. These patients (and their providers) are often anxious to begin treatment right away. The problem is that many young women haven’t started or completed their families at the time of their diagnosis.
Tech CornerOctober 11, 2018
Precision medicine and making sense of data
JAX professor calls for concerted effort to align data across patients and systems with comparable and consistent formats and contextual meaning.
Press ReleaseOctober 09, 2018
Advancing therapeutic gene editing
NIH awards $3.5M to JAX under multi-institution Somatic Cell Genome Editing program.
Search MagazineSeptember 11, 2018
Jumping genes and where to find them
Assistant Professor Christine Beck, Ph.D., is uncovering how recurring sequences in our genomes might shed light on genome stability, as well as diseases like cancer.

JaxWeb.L.LabStaff

Uma Arora

PhD Student

Investigating the composition and diversity of centromeric sequence amongst Mus musculus subspecies and autosomes vs sex chromosomes to understand their significance in evolution.
Beth Dumont, Ph.D.

Assistant Professor
Brett Haines, B.S.

Research Assistant

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Open Positions

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Selected Publications

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