The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.
Researching the mechanisms that generate genetic diversity through the lens of evolution
My primary areas of interest are software engineering, bioinformatics, and genomics.
Comparing mutagenesis techniques to probe the logic underlying cis-regulatory elements.
Interested in genetic diversity and evolution of wild and wild-derived mice
Developing novel CRISPR protocols to isolate and sequence recalcitrant regions of the genome
Unraveling the patterns of genetic mechanisms that give rise to genetic diversity in house mouse populations.
A research team led by Albert Cheng developed a new method, CASFx, that leverages CRISPR technology to alter messenger RNA...
The Maine Cancer Genomics Initiative at The Jackson Laboratory is pleased to offer a special virtual event on genomic tumor...
Developing new computational strategies to understand complex genetic systems.
Investigating the composition and diversity of centromeric sequence amongst Mus musculus subspecies and autosomes vs sex chromosomes to...
The JAX Scholar award offers exceptional early-career scientists the opportunity to develop their independent research program at The...
Conducting research to elucidate and compare the transcriptional network structure and dynamics driving organogenesis.
My primary research focus is on leveraging genetically diverse mouse populations to uncover genetic and epigenetic mechanisms that govern...
My work utilizes a combination of high-performance parallel and distributed computing resources, machine learning, and algorithm...
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