The Dumont Lab
Researching the mechanisms that generate genetic diversity through the lens of evolution
Principal Investigator
Location
Topics
Our Research Focus
The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.
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Research HighlightJanuary 27, 2023Improving iPSC research with new cell lines
A stable iPSC line, KOLF2.1J, has been established to act as a high-quality baseline platform for modeling human disease. -
Press ReleaseJanuary 09, 2023New property licensing agreement with General Biomics announced
New licensing agreement between General Biomics and JAX aims to better understanding the microbiome in human disease. -
Research HighlightDecember 19, 2022New method for finding gene silencers
A group led Ryan Tewhey and Kousuke Mouri developed a method to detect silencer activity at a genome-wide scale to address the imbalance and improve understanding of the full gene regulatory landscape. -
Press ReleaseDecember 16, 2022Global Biodata Coalition announces the first set of Global Core Biodata Resources
JAX's Mouse Genome Database (MGD) will be included in the first list of Global Core Biodata Resources (GCBRs).
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Research HighlightJanuary 27, 2023Transposable elements within the dynamic human genome
Christine Beck is examining transposable elements within the human genome. -
Research HighlightDecember 20, 2022Revealing the biology of senescent cells
JAX is playing a major role to bridge experimental mouse and human data and reveal the biology of senescent cells. -
Press ReleaseDecember 19, 2022An outstanding year of growth at The Jackson Laboratory
2022 has been a notable year for The Jackson Laboratory, with great achievements and many reasons to celebrate continued momentum for JAX’s mission. -
Press ReleaseDecember 07, 2022New Endowed Chair marks a milestone for JAX
Professor Nadia Rosenthal is the inaugural chairholder of the The Maxine Groffsky Endowed Chair, made possible through a generous gift commitment by Maxine Groffsky.