The broad objective of my research program is to understand the causes and consequences of variation in the cellular mechanisms that govern DNA inheritance: genetic recombination, chromosome segregation, and de novo mutation. To date, my work has combined wet-bench and computational approaches in multiple mammalian model systems to investigate variation in two recombination mechanisms, crossing-over and gene conversion. Over the next several years, my research group will work at the leading edge of genomics, evolutionary genetics, and cytogenetics to advance our understanding of recombination rate variation from diverse biological perspectives.
Campbell CD, Chong JX, Malig M, Ko A, Dumont BL, Han L, Vives L, O'Roak BJ, Sudmant PH, Shendure J, Abney M, Ober C, Eichler EE. Estimating the human mutation rate using autozygosity in a founder population. Nat Genet. 44(11):1277-81, 2012
Dumont BL, White MA, Steffy B, Wiltshire T, Payseur BA. Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps. Genome Res. 21(1):114-25, 2011
Dumont BL, Payseur BA. Genetic analysis of genome-scale recombination rate evolution in house mice. PLoS Genet. 7(6):e1002116, 2011
Borodin PM, Basheva EA, Torgasheva AA, Dashkevich OA, Golenishchev FN, Kartavtseva IV, Mekada K, Dumont BL. Multiple independent evolutionary losses of XY pairing at meiosis in the grey voles. Chromosome Res. 20(2):259-68 ,2012
Dumont BL. Interlocus gene conversion explains at least. 7% of single nucleotide variants in human segmental duplications. BMC Genomics. 16:456, 2015