Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

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Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in how genetic background influences the function of the immune system in tumors and visceral fat.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Olivia Hon

Research Assistant II

Cardiovascular Research
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.
Daniel Skelly, Ph.D.

Research Scientist

Studying genetic variation and its effects on cellular phenotypes and observable traits. Developing statistical models to analyze large genomics datasets.

Selected Publications

Highlighted Abstract

Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.

View full list of publications

Press ReleaseNovember 12, 2019
Amy Dunn: Wunderkind
STAT taps Jackson Laboratory postdoc Amy Dunn for 2019 class of future science superstars.
- Alzheimer's Disease
- Neurodegenerative and Neuromuscular Diseases
Blog PostOctober 28, 2019
New US Preventive Services Task Force recommendations
The USPSTF updated this important screening recommendation in August, 2019. It now recommends screening for potentially harmful BRCA1 and BRCA2 gene mutations in women with a personal or family history of breast, ovarian, tubal, or peritoneal cancer or an ancestry associated with BRCA1/2 gene mutations.
Search MagazineOctober 11, 2019
Sherlock Holmes of the inner ear
JAX scientist Vidhya Munnamalai investigates the complex puzzle of cochlear development in an effort to cure hearing loss.
Search MagazineOctober 02, 2019
Maximizing research potential
Six JAX early-career faculty members receive major grant awards.

Research HighlightOctober 31, 2019
Improving transgene research with split selectable markers
JAX Assistant Professor Albert Cheng led a team to develop split selectable markers, a method that can indicate the successful integration of multiple transgenes.
Featured ArticleOctober 28, 2019
Cancer researchers embrace AI to accelerate development of precision medicine
Using Microsoft AI, The Jackson Laboratory is empowering researchers and medical professionals with a powerful digital encyclopedia that has the potential to change the way we study and treat cancer.
Research HighlightOctober 03, 2019
Abnormal splicing and brain disease
JAX Associate Professor Zhong-wei Zhang explores the effects of abnormal alternative RNA splicing during neurodevelopment, which can lead to increased susceptibility to seizures in adults.
Press ReleaseSeptember 25, 2019
Looking for clues to longer, healthier life
$7.9 million grant to JAX scientists extend an important testing program for age-retarding agents