Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., F.Med.Sci

The Jackson Laboratory
Bar Harbor, ME

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

Lab Staff

Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Associate Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
James Godwin, Ph.D.

Research Scientist

Investigates the molecular mechanisms underpinning regeneration and scarring in adult tissues using comparative biology approaches that combine mouse repair models with salamander-based tools for discovery.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in the intersection of tissue regeneration, cancer, and the mammalian immune system.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Mike McLellan

Ph.D. Student
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Alexander Pinto, Ph.D.

Research Scientist
Nadia Rosenthal, Ph.D., F.Med.Sci

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Selected Publications

View full list of publications

Research HighlightAugust 03, 2017
Immune cells play key role in cardiac regeneration
Recently, a team led by JAX Professor and Scientific Director Nadia Rosenthal, Ph.D., F.Med.Sci., and Research Scientist James Godwin, Ph.D., explored the role of the immune response in heart regeneration in the axolotl (salamander).
Blog PostJanuary 23, 2017
The Economist: The Mischief of Mice
The world’s favorite lab animal has been found wanting, but there are new twists in the mouse’s tale
Press ReleaseDecember 02, 2015
JAX Professor, Scientific Director Nadia Rosenthal named AAHMS Fellow
The Australian Academy of Health and Medical Sciences (AAHMS) has named Nadia Rosenthal, Ph.D., F.Med.Sci., professor and scientific director of The Jackson Laboratory’s headquarters mammalian genetics campus, as a 2015 Fellow.
Press ReleaseNovember 17, 2015
JAX Scientific Director Nadia Rosenthal named editor in chief of new Nature journal
Nadia Rosenthal, Ph.D., F.Med.Sci., professor and scientific director of mammalian genetics at The Jackson Laboratory, is the editor in chief of npj Regenerative Medicine, a new addition to the prestigious Nature journal group.

Research HighlightJuly 06, 2017
‘Guardians of the heartbeat’
Cardiac macrophages could be key to treating heart disease or damage
Research HighlightMarch 29, 2017
Focusing on mechanics may be key in unlocking the heart’s ability to heal itself
Developmental processes may prevent the human heart's ability to regenerate.
The Search Magazine ArticleJuly 06, 2015
Big thinker
Renaissance woman Nadia Rosenthal, a distinguished scientist, mentor and leader, will oversee the scientific pursuits of JAX’s Bar Harbor campus.
Press ReleaseMarch 24, 2015
International mammalian genetics leader Nadia Rosenthal joins The Jackson Laboratory as Scientific Director
International mammalian genetics leader Nadia Rosenthal joins The Jackson Laboratory as Scientific Director