Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., F.Med.Sci

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

View all research positions

Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in the intersection of tissue regeneration, cancer, and the mammalian immune system.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Nadia Rosenthal, Ph.D., F.Med.Sci

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Selected Publications

Highlighted Abstract

Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.

View full list of publications

Press ReleaseFebruary 18, 2019
A crystal ball for looking at the complexity of the 3D genome
A team led by Jackson Laboratory Professor Yijun Ruan, Ph.D., has developed a new method, called ChIA-Drop, that allows researchers to investigate 3D genomic structures with unprecedented precision and clarity.
Research HighlightJanuary 29, 2019
Tracing a pathway to leukemia
New research led by Jennifer Trowbridge provides insight into risk factors for clonal hematopoiesis-to-leukemia progression.
- Cancer/Tumors
- Leukemia
- Aging
- Cancer
Press ReleaseJanuary 09, 2019
Linking therapy to an asthma-driving molecule
Recent research suggests long non-coding RNAs (lncRNAs) contribute to immune dysfunction, and JAX Assistant Professor Adam Williams is investigating the roles they may play in asthma.
Press ReleaseDecember 27, 2018
New Alzheimer's models show how human diversity affects disease onset
A new genetically diverse mouse population is opening possibilities for translational research into Alzheimer’s disease that accurately recreates human disease symptoms and progression.

Search MagazineFebruary 11, 2019
The engines of genetic diversity
JAX Assistant Professor Beth Dumont, Ph.D., is working to better understand the processes that give rise to genetic diversity, and how specific variations can contribute to disease susceptibility.
Minute to UnderstandingJanuary 11, 2019
Minute to Understanding: What is gene therapy?
Mutations in our genes can cause life-threatening diseases, and sometimes there is no drug or surgery available for your doctor to prescribe. Enter gene therapy.
- Precision medicine
- Genetics and Genomics
Press ReleaseJanuary 07, 2019
JAX researcher lands Department of Defense grant to study endometriosis
Supported by a grant from the U.S. Department of Defense, Elise Courtois is researching the genetic mechanisms underlying endometriosis, a painful disease with no non-surgical treatment.
Research HighlightDecember 14, 2018
Gene knockdown induces deficits reminiscent of aging and Alzheimer's
JAX researchers find that reducing Hp1bp3 expression mimics age-related cognitive decline through mechanisms reminiscent of aging and Alzheimer's disease