Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

View all research positions

Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Associate Research Scientist

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in how genetic background influences the function of the immune system in tumors and visceral fat.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Olivia Hon

Research Assistant II

Cardiovascular Research
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Aimee Picard

Assistant to the Scientific Director and Sr. Manager Research Administrative Support Services
Alexander Pinto, Ph.D.

Research Scientist
Natalie Powers, Ph.D.

Postdoctoral Associate

Interested in how regulatory and epigenetic factors can influence the inheritance and expression of heritable traits, especially complex traits.
Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.
Daniel Skelly, Ph.D.

Research Scientist

Studying genetic variation and its effects on cellular phenotypes and observable traits. Developing statistical models to analyze large genomics datasets.
Kyuson Yun, Ph.D.

Affiliated Scientist

Focused on understanding mechanisms that regulate stem cell self-renewal and transformation in brain tumors.

Selected Publications

Highlighted Abstract

Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including heart failure. Physiological factors leading to cardiac fibrosis have been recognized for decades. However, the specific cellular and molecular mediators that drive cardiac fibrosis, and the relative effect of disparate cell populations on cardiac fibrosis, remain unclear.

View full list of publications

Blog PostMarch 01, 2021
When should you seek clinical confirmation of consumer genomic test results?
For many, testing provides a window into their innermost self, their genome, and a new way to learn about themselves.
Search MagazineFebruary 23, 2021
Help for the smallest and rarest
A JAX research team led by Cat Lutz launched a project to develop gene therapy strategies and to test small molecules for the treatment of multiple sulfatase deficiency, a rare genetic disorder.
- Rare Diseases
- Neurodegenerative and Neuromuscular Diseases
Research HighlightFebruary 09, 2021
Alzheimer’s disease, microglia and genetic diversity
Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease.
- Alzheimer's Disease
- Neurodegenerative and Neuromuscular Diseases
Tech CornerFebruary 01, 2021
New coronavirus variants spark concerns
Mutations in SARS-CoV-2 are generating viral variants that change the properties of the virus and affect the response to the COVID-19 pandemic.

Press ReleaseFebruary 25, 2021
A new reference for global genomic diversity
Exactly 20 years after the successful completion of the "Human Genome Project," an international group of researchers, the Human Genome Structural Variation Consortium (HGSVC), has now sequenced 32 human genomes at high resolution.
Press ReleaseFebruary 16, 2021
International research team to explore immune therapy for heart disease
Nadia Rosenthal joins international team to study the immune system’s effects on the heart’s connective tissue.
Research HighlightFebruary 01, 2021
Novel antibody tests reveal complexity of immune response to covid-19
The interaction of SARS-CoV-2, the novel coronavirus causing the global COVID-19 pandemic, and the human immune system has been the focus of intensive research.
Tech CornerFebruary 01, 2021
Machine learning: Shining a light on genomic function
Machine learning platforms can be fed data to "teach" them to learn patterns and predict outcomes, and they are becoming more important all the time in biomedical research. But what are they? How do they work? And can we peer into the black box of their inner functions to make them more powerful for prediction and discovery?

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

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Contact The Rosenthal Lab

Open Positions

Selected Publications

Highlighted Abstract

When should you seek clinical confirmation of consumer genomic test results?

Help for the smallest and rarest

Alzheimer’s disease, microglia and genetic diversity

New coronavirus variants spark concerns

A new reference for global genomic diversity

International research team to explore immune therapy for heart disease

Novel antibody tests reveal complexity of immune response to covid-19

Machine learning: Shining a light on genomic function