Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., F.Med.Sci

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

View all research positions

Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in how genetic background influences the function of the immune system in tumors and visceral fat.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Olivia Hon

Research Assistant II

Cardiovascular Research
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Nadia Rosenthal, Ph.D., F.Med.Sci

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Selected Publications

Highlighted Abstract

Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.

View full list of publications

Tech CornerJuly 17, 2019
Improved methods, expanded capabilities: Analyzing cells one at a time
Researchers are able to do many things today that were impossible five, three, even one year ago. Some of the new options are science-fiction-level impressive.
Press ReleaseJuly 15, 2019
Research team creates new research models for Snyder-Robinson Syndrome
Two new mouse models created to study neurological developments in Snyder-Robinson Syndrome to advance global understanding of this rare disease.
Tech CornerJune 17, 2019
The genome of Eve (the mouse)
C57BL/6—aka Black 6—is the most widely used mouse strain in research. Its reference genome was published in 2003 and has been carefully curated over the years since.
Press ReleaseMay 20, 2019
Must a high-fat diet lead to obesity-related metabolic syndrome?
Researchers say that harnessing a specific immune response to prevent inflammation could prevent insulin resistance, cardiovascular disease.

Research HighlightJuly 17, 2019
JAX postdoc Kira Young lands ASH Scholar Award
JAX postdoctoral associate Kira Young, Ph.D., has received the ASH Scholar Award from the American Society for Hematology to support her research studying “old blood.” Young is using the award to understand the different types of white blood cells that make up the immune system and how they change as we age.
- Aging
- Cancer
Search MagazineJune 18, 2019
Connected through Science
When Isabelle Chen, a senior at The Ethel Walker School in Simsbury, Conn., met Ann Bresnahan ‘69 during a science alumnae panel discussion at Bresnahan’s 50-year high school reunion, the two knew that they shared a passion for science.
Search MagazineMay 22, 2019
JAX scientists speak out on the crisis of opioid addiction
JAX scientists are intensifying their efforts to shed light on the genetic and neurobiological causes of addiction, along with the impact of environmental influences.
Research HighlightMay 20, 2019
Revealing cellular traits, one cell at a time
Scientists have developed an expanded toolkit that enables investigations of cellular traits at the single cell level at an unprecedented level of detail.