Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

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Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in how genetic background influences the function of the immune system in tumors and visceral fat.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Olivia Hon

Research Assistant II

Cardiovascular Research
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Selected Publications

Highlighted Abstract

Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.

View full list of publications

Research HighlightSeptember 20, 2019
An epigenetic eraser
The genome editing tool, Casilio, can be used to efficiently remove methyl groups from DNA and activate expression of methylation-silenced genes in experimental systems. Casilio was created by Jackson Laboratory Assistant Professor Albert Cheng.
Press ReleaseSeptember 13, 2019
The microbiome and the nursing home
JAX, UConn researchers explore how patients’ microbiome, and risk of infection, change after time in a skilled nursing facility.
Research HighlightAugust 21, 2019
The long-term maintenance of sperm production in mammals
A research team led by Professor and Janeway Distinguished Chair Robert Braun, Ph.D., and Associate Research Scientist Manju Sharma, Ph.D., found a rare subpopulation of spermatogonial cells expressing a specific protein, EOMES, that appear to represent the elusive long-lived spermatogonial stem cells that support continued spermatogenesis.
Search MagazineJuly 23, 2019
Unraveling the genetics of heart failure
JAX predoctoral associate Anthony Pettinato has been awarded a fellowship from the American Heart Association to support his doctoral research program. He is using genetics to understand the causes of heart failure.
- Cardiovascular
- Genetics and Genomics

Search MagazineSeptember 19, 2019
The path to personalized treatments for rare diseases
The genetic study of rare diseases is giving us insight into how to examine and treat more common diseases, said JAX experts at a recent JAXtaposition event in Portland, ME.
- Rare Diseases
- Neurodegenerative and Neuromuscular Diseases
Research HighlightAugust 21, 2019
The future of human and experimental genetics
This year, science luminaries came to Maine for an additional special symposium that celebrated the McKusick Short Course's 60th anniversary. The symposium title, “The Future of Human and Experimental Genetics,” foreshadowed the theme of the talks.
Press ReleaseAugust 01, 2019
Preventing anaphylaxis
New research by JAX Assistant Professor Adam Williams, published in Science, points the way to more precise allergy testing as well as identifying new approaches for treating allergy.
- Immunology
- Genetics and Genomics
Tech CornerJuly 17, 2019
Improved methods, expanded capabilities: Analyzing cells one at a time
Researchers are able to do many things today that were impossible five, three, even one year ago. Some of the new options are science-fiction-level impressive.