Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., F.Med.Sci

The Jackson Laboratory
Bar Harbor, ME

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in the intersection of tissue regeneration, cancer, and the mammalian immune system.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Mike McLellan

Ph.D. Student
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Alexander Pinto, Ph.D.

Research Scientist
Nadia Rosenthal, Ph.D., F.Med.Sci

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Selected Publications

View full list of publications

Press ReleaseJanuary 16, 2018
JAX scientists publish new 'census' of mouse heart cells and their networks
Single-cell characterization of non-myocyte heart cells offers new insights into the structure and function of the cardiac cellular landscape, including sex-based differences.
Search MagazineNovember 15, 2017
Exploring the diet-life span connection
What's wrong with too many cupcakes? Mauro Costa's research with mice is revealing the metabolic effects of our dietary choices.
Research HighlightJuly 06, 2017
‘Guardians of the heartbeat’
Cardiac macrophages could be key to treating heart disease or damage
Search MagazineFebruary 13, 2017
How do you mend a broken heart?
JAX researchers are searching for ways to repair the damage inflicted by heart disease, by harnessing regenerative powers that humans lack but that abound in the animal kingdom.

Search MagazineDecember 12, 2017
JAX down under
The Jackson Laboratory’s connections to Australia are explored, focusing on The Rosenthal Lab and the work of Australian researcher Sarah Stephenson.
Research HighlightAugust 03, 2017
Immune cells play key role in cardiac regeneration
Recently, a team led by JAX Professor and Scientific Director Nadia Rosenthal, Ph.D., F.Med.Sci., and Research Scientist James Godwin, Ph.D., explored the role of the immune response in heart regeneration in the axolotl (salamander).
Research HighlightMarch 29, 2017
Focusing on mechanics may be key in unlocking the heart’s ability to heal itself
Developmental processes may prevent the human heart's ability to regenerate.
Blog PostJanuary 23, 2017
The Economist: The Mischief of Mice
The world’s favorite lab animal has been found wanting, but there are new twists in the mouse’s tale