Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

View all research positions

Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Associate Research Scientist

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in how genetic background influences the function of the immune system in tumors and visceral fat.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Olivia Hon

Research Assistant II

Cardiovascular Research
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Aimee Picard

Assistant to the Scientific Director and Sr. Manager Research Administrative Support Services
Alexander Pinto, Ph.D.

Research Scientist
Natalie Powers, Ph.D.

Postdoctoral Associate

Interested in how regulatory and epigenetic factors can influence the inheritance and expression of heritable traits, especially complex traits.
Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.
Daniel Skelly, Ph.D.

Research Scientist

Studying genetic variation and its effects on cellular phenotypes and observable traits. Developing statistical models to analyze large genomics datasets.
Kyuson Yun, Ph.D.

Affiliated Scientist

Focused on understanding mechanisms that regulate stem cell self-renewal and transformation in brain tumors.

Selected Publications

Highlighted Abstract

Macrophages are integral components of cardiac tissue and exert profound effects on the healthy and diseased heart. Paradigm shifting studies using advanced molecular techniques have revealed significant complexity within these macrophage populations that reside in the heart. In this final of a 4-part review series covering the macrophage in cardiovascular disease, the authors review the origins, dynamics, cell surface markers, and respective functions of each cardiac macrophage subset identified to date, including in the specific scenarios of myocarditis and after myocardial infarction. Looking ahead, a deeper understanding of the diverse and often dichotomous functions of cardiac macrophages will be essential for the development of targeted therapies to mitigate injury and orchestrate recovery of the diseased heart. Moreover, as macrophages are critical for cardiac healing, they are an emerging focus for therapeutic strategies aimed at minimizing cardiomyocyte death, ameliorating pathological cardiac remodeling, and for treating heart failure and after myocardial infarction.

View full list of publications

Research HighlightAugust 03, 2020
Unlocking age-dependent coronavirus susceptibility
Genetically varied mouse populations revealing genetic elements contributing to SARS-CoV-2 infection risk.
Research HighlightJuly 28, 2020
Assembling the 3D genome with ChIA-PIPE
ChIA-PIPE expands the capabilities of previous analysis pipelines that identified chromatin loops, the DNA sequences of linked DNA, and protein binding peaks within the DNA sequences.
Research HighlightJuly 14, 2020
How to heal a heart
Nadia Rosenthal joins international team to study the immune system’s effects on the heart’s connective tissue.
Blog PostJune 30, 2020
Moving beyond amyloid to treat Alzheimer's disease
The repeated clinical trial failures of Alzheimer’s disease therapies based on clearing beta-amyloid have been discouraging, but new research strategies and capabilities are providing renewed hope.

Press ReleaseAugust 03, 2020
Correcting splicing-factor defects in disease
Five-year, $2.1 million federal grant to Olga Anczuków of JAX will reveal the role of splicing-factor defects in cardiac or neurological disorders, cancer, and more.
Press ReleaseJuly 28, 2020
Building better mouse models for addiction research
NIDA grant to Vivek Kumar of JAX will fund development of new preclinical models of addiction.
Featured ArticleJuly 06, 2020
Telomere length in mice
Telomere length in animals is not significantly affected by inbreeding and domestication. It varies across strains and sub-strains of mice, as does lifespan, and there is no direct correlation between telomere length and longevity within a population.
Search MagazineJune 23, 2020
More genetic counselors are needed to realize the potential of precision medicine
The Global Alliance for Genomics and Health predicts that 60 million genomes will be sequenced worldwide by 2025.
- Precision medicine
- Genetics and Genomics

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

Open Positions

Selected Publications

Highlighted Abstract

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