The Rosenthal Lab
Investigating the role of growth factors, stem cells and the immune system in cardiovascular and skeletal muscle disease and regeneration.
Principal Investigator
Location
Topics
The Rosenthal Lab uses mammalian genetics to explore the the role of growth factors, stem cells and the immune system in the development and regeneration of heart and skeletal muscle. Our recent research uses mouse genetic diversity panels to investigate the role of aging, cellular interactions and the immune system in cardiovascular disease and repair. Genetic mapping reveals distinct spectra of cell composition and response in regenerative scenarios, demonstrating how background genetics can either facilitate or prevent tissue repair. In our infectious disease research, we have recently created more precise mouse models for SARS-CoV-2, using them to examine the role of host genetics in susceptibility and disease course. This work was published in Nature Communications.
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Featured ArticleApril 25, 2024Postdocs discuss neurodegenerative conditions for 'Scientifically Speaking'
JAX’s 'Scientifically Speaking' virtual series continues May 7, featuring two postdoctoral associates taking on the challenge of neurodegenerative disease. -
Featured ArticleApril 23, 2024Charles Lee receives honorary doctor of science degree from University of Alberta
Charles Lee awarded honorary doctor of science degree from the University of Alberta and will deliver the convocation address to Faculty of Science graduates. -
Research HighlightApril 03, 2024Making mice a more powerful research tool
A new protocol sets the stage for researchers to directly compare mouse and human cells, and readily incorporates genetic diversity into mouse-based research to more closely approximate human health conditions. -
Research HighlightMarch 26, 2024CRISPR provides potential cardiomyopathy treatment
JAX researchers have developed a potential new treatment for dilated cardiomyopathy (DCM), a sometimes fatal heart condition that affects as many as one in 200 adults worldwide.
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Research HighlightApril 23, 2024Investigating age-related immune dysfunction in lung epithelial cells
With $13 million in renewed support, Karolina Palucka will further study how aging affects airway epithelial cells’ efficiency in combating viral infections. -
Featured ArticleApril 23, 2024Dan Cortes: gearing up for discovery
Dan Cortes multifaceted journey has led him to pioneering stem cell research within the Pera lab, where he explores the intricate genetic landscape underlying neurological diseases and disorders. -
Featured ArticleMarch 26, 2024Working to characterize the function of protein-coding genes in the mouse
Using KOMP2, JAX researchers have now generated and characterized more than 2,000 knockout mice, gaining important insights into mammalian genetics and potential health impacts. -
Press ReleaseMarch 21, 2024Aubrey Watkins III appointed VP of Corporate Development
Industry leader and innovator will help advance JAX’s mission.