Jackson Laboratory

The Rosenthal Lab

Principal Investigator: Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

The Jackson Laboratory
Bar Harbor, ME

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Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

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Open Positions

Job	Job Title	Location	Description

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research
Jane Branca

Biomedical Technologist III
Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.
Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.
Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.
John P. Graham, Ph.D.

Associate Research Scientist

I am interested in how genetic background influences the function of the immune system in tumors and visceral fat.
Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.
Olivia Hon

Research Assistant II

Cardiovascular Research
Mike McLellan

Ph.D. Student

Studies cell type diversity in the heart and its role in repair after injury.
Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
Natalie Powers, Ph.D.

Postdoctoral Associate

Interested in how regulatory and epigenetic factors can influence the inheritance and expression of heritable traits, especially complex traits.
Nadia Rosenthal, Ph.D., FMedSci, FAAHMS

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.
Daniel Skelly, Ph.D.

Research Scientist

Studying genetic variation and its effects on cellular phenotypes and observable traits. Developing statistical models to analyze large genomics datasets.

Selected Publications

Highlighted Abstract

Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.

View full list of publications

Research HighlightFebruary 24, 2020
Gene silencers and their vital roles in development
New research shows that silencers modify 3D chromatin organizations to suppress the expression of certain genes at certain time points during development. Disruption of the process can lead to developmental disorders and has also been implicated in certain cancers.
- Tumor suppressor genes
- Genetics and Genomics
Press ReleaseJanuary 30, 2020
Advancing genomics for pediatric orthopedic diseases
Shriners Hospitals for Children and The Jackson Laboratory announce research affiliation for genomic studies of pediatric patients.
- Bones and Joints
- Genetics and Genomics
Press ReleaseJanuary 27, 2020
Northeastern launches the Roux Institute in Maine
The Jackson Laboratory is partnering with The Roux Institute at Northeastern to bring an engine of innovation, talent and economic growth to the Portland, Maine region.
Tech CornerJanuary 21, 2020
5 questions with Katja Brose
Chan Zuckerberg Initiative (CZI) Science Program Officer Katja Brose visited JAX to speak about CZI and moderate an Alzheimer’s disease research panel discussion at the JAX Healthcare Forum, an annual gathering of leaders in a wide variety of healthcare fields. JAX was able to catch up with Dr. Brose after her sessions.

Research HighlightFebruary 10, 2020
Immune system changes with age differ between men and women
A research team led by Duygu Ucar and Jacques Banchereau analyzed immune cells from a large cohort of healthy people spanning the adult life span and found significant differences in immune gene regulation and function between the sexes that increased with age.
- Aging
- Aging
Research HighlightJanuary 29, 2020
Pioneers in recombination
In a paper in Genes & Development, Assistant Professor Chris Baker led a team that shows two proteins, PRDM9 and HELLS, form a complex that binds to hot spots and opens the site to the DNA breakage and repair needed for recombination. As “pioneer factors” in the process, both proteins are needed for successful meiosis and fertility.
- Fertility Research
- Genetics and Genomics
Blog PostJanuary 24, 2020
Using prenatal cell-free DNA screening to prepare for a gender reveal
The American College of Obstetricians and Gynecologists (ACOG) recommends that both aneuploidy screening and diagnostic testing options be offered to all pregnant women.
- Reproductive Biology
- Genetics and Genomics
Press ReleaseJanuary 21, 2020
Andy Greene changes teams
Distinguished biomedical engineer and researcher comes to The Jackson Laboratory
- Genetic Tools
- Genetics and Genomics