The Rosenthal Lab

Rosenthal’s research uses mammalian genetics to explore the embryonic development of heart and skeletal muscle and the regeneration of adult tissues. She focuses on muscle and cardiac developmental genetics and the role of growth factors, stem cells and the immune system in tissue regeneration.

She is a global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair, and is a participant in EUCOMM, the European Conditional Mouse Mutagenesis Program, where she coordinates the selection and production of new Cre driver strains for the international mouse genetics community.

Lab Staff

Zachery Beal

Research Assistant I

Regenerative Research

Jane Branca

Biomedical Technologist III

Mauro Costa, Ph.D.

Research Scientist

Studies congenital heart disease and the complex interplay between genetic predisposition and cardiac stress mediated by obesity, high blood pressure and myocardial infarction.

Elvira Forte, Ph.D.

Research Assistant IV

Employs mouse genetic models to study the role of stromal cells in cardiac development and in scar formation in response to ischemic injury.

Milena B. Furtado, M.Sc., Ph.D.

Associate Research Scientist

Broad research interests include the study of organ fibrosis, and more specifically, heart fibrosis, using mouse genetic models.

John P. Graham, Ph.D.

Associate Research Scientist

I am interested in the intersection of tissue regeneration, cancer, and the mammalian immune system.

Muneer Hasham, Ph.D.

Research Scientist

Wide array of research interests includes infectious diseases, immune disorders and cancer pathogenesis. He also has an interest in developing and streamlining biological protocols and processes.

Mike McLellan

Ph.D. Student

Raghav Pandey, Ph.D.

Postdoctoral Associate

Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.

Nadia Rosenthal, Ph.D., F.Med.Sci

Scientific Director and Professor, The Jackson Laboratory for Mammalian Genetics

Global leader in the use of targeted mutagenesis in mice to investigate muscle development, disease and repair.

New research effort to understand role of APOE mutation in Alzheimer’s disease

Inheriting a specific genetic variant, APOEε4, is linked with 15-20 percent rise in risk of developing Alzheimer’s, with at least 20 other genes implicated. JAX researchers are studying how APOEε4 risk depends on other genes, in mice with a wide variety of genetic backgrounds.

What is epigenetics?

Learn how epigenetic changes can affect an individual without physically changing their DNA sequence.

The future of aging

University of Arizona researcher George Sutphin had never touched a mouse before he arrived as a postdoctoral associate in the Korstanje lab at The Jackson Laboratory. Now he depends on the mouse and other models as he works to develop new clinical interventions to extend healthy human lifespan and treat age-associated disease.

Tuning in to the inner ear

Basile Tarchini, Ph.D., is working to understand the basic mechanisms underlying hair cell development, with the goal of restoring hearing following injury.

The distinct forms of an important genomic disruption

A new paper further explains the genomic disruption known as the tandem duplicator phenotype (TDP), a common attribute in some of the most deadly cancers of women.

JAX receives $1.5 million for glaucoma research

Gareth Howell named Diana Davis Spencer Foundation Chair for Glaucoma Research

Detecting human genome structural variation with long read sequencing

A research team led by Chia-lin Wei is using technology to more easily detect and classify important types of difficult-to-find genomic alterations, known as structural variants.