Jennifer Trowbridge, Ph.D.
Associate Professor
Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.
The Trowbridge laboratory studies cell fate regulation within the hematopoietic system. Our current focus is on the epigenetic regulation of hematopoietic stem cell (HSC) and progenitor cell lineage commitment in three contexts: (1) normal blood development and maintenance, (2) alterations that occur during the process of aging, and (3) alterations that occur during the process of transformation giving rise to leukemia. Our ultimate goal is to reveal epigenetic patterns and processes that are uniquely deregulated during aging and/or transformation, which can be used to identify novel biomarkers of disease and targets for development of therapeutics.
Education and experience
Education
Dana-Farber Cancer Institute
Postdoctoral fellow, hematology
2012
University of Western Ontario
Ph.D., microbiology & immunology
2006
University of Western Ontario
B.S., genetics
2002
Experience
Tufts University
Adjunct Faculty
2012-present
The Jackson Laboratory
Assistant Professor
2012-present
University of Maine
Adjunct Faculty at the Graduate School of Biomedical Sciences
2012-present
Harvard Medical School
Instructor in Pediatrics
2011-2012
Harvard Medical School
Research Fellow in Pediatrics
2006-2011
Grants, Honors, and Accomplishments
Ellison Medical Foundation New Scholar Award in Aging
2013-present
American Society of Hematology (ASH) Scholar Award
2011-2013
Leukemia & Lymphoma Society Career Development Program Fellowship
2007-2010
Poland Award for Top Graduating Ph.D. Student
2006-2007
National Cancer Institute of Canada (NCIC) Research Studentship
2005-2007
Ontario Graduate Society (OGS) Studentship
2002-2003
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Research HighlightApril 12, 2021New research asks how bone marrow affects us as we age
New research done by JAX scientists investigates how bone marrow affects our health as we age. -
Research HighlightJanuary 29, 2019Tracing a pathway to leukemia
New research led by Jennifer Trowbridge provides insight into risk factors for clonal hematopoiesis-to-leukemia progression. -
Research HighlightDecember 13, 2016The aging immune system and loss of adaptive immune response
Using mice spanning a spectrum of ages, a Jackson Laboratory research team led by Assistant Professor Jennifer Trowbridge, Ph.D., investigated changes in the maturation process of hematopoietic stem cells over time. -
Press ReleaseJuly 11, 2016Open chromatin profiling key to identifying leukemia cells of origin
Jackson Laboratory (JAX) researchers have found a precise and reliable way — whole-genome profiling of open chromatin — to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome
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Press ReleaseAugust 18, 2020How does CHIP raise risk for blood diseases?
A $2.4M National Institute on Aging grant will fund new JAX research in age-related blood condition. -
Research HighlightJuly 23, 2018
$2.4 million grant to JAX for strategies to extend healthy function of blood and immune systems during aging
The five-year grant enables studies exploring ways to boost the hematopoietic system for better regenerative capacity, immune cell function during aging. -
Search MagazineDecember 01, 2016Young blood
JAX cancer researcher Jennifer Trowbridge wants to know why, specifically, older people are more likely to get acute myeloid leukemia. -
Press ReleaseJuly 23, 2014
Maine Cancer Foundation awards grants to four Jackson Laboratory scientists
Four Jackson Laboratory (JAX) scientists will receive grants for their cancer-related research from Maine Cancer Foundation (MCF).