Jackson Laboratory

The Ren Lab

Principal Investigator: Guangwen "Gary" Ren, Ph.D.

The Jackson Laboratory
Bar Harbor, ME

Contact me at: 207-288-6783

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To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse

OUR RESEARCH FOCUS

The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.

Full Scientific Report

The Jackson Laboratory Cancer Center

Press ReleaseNovember 13, 2018
V Foundation funds JAX cancer research for third straight year
Armed with new funding from the V Foundation, Olga Anczuków-Camarda is uncovering genetic changes in the breast, paving the road to early cancer detection and prevention.
Press ReleaseOctober 24, 2018
Data provides new hope for pediatric brain tumor patients
Using computer models, researchers have identified a potential new therapy that would reduce the long-term side effects of radiation therapy in pediatric brain cancer patients.
Research HighlightSeptember 26, 2018
Making B-lymphocyte targeting work in treating type 1 diabetes
$2.2M grant to JAX Professor David Serreze will fund search for new approaches to fighting autoimmune destruction
Blog PostSeptember 25, 2018
American Cancer Society colon cancer screening guidelines
Could early colorectal cancer screening recommended by the American Cancer Society identify more people at high risk for hereditary cancer?
- Colon and Rectal Cancer
- Cancer

Blog PostOctober 31, 2018
Can we do a better job of preserving fertility and ovarian function for young breast cancer survivors?
Young women with a new cancer diagnosis are faced with a number of challenges. These patients (and their providers) are often anxious to begin treatment right away. The problem is that many young women haven’t started or completed their families at the time of their diagnosis.
Research HighlightOctober 11, 2018
Stuck in a dangerous cycle
Paper provides important insight for B-cell lymphomagenesis from mouse models to human disease.
Press ReleaseSeptember 25, 2018
Brain cancer’s lethal differences: tracking extra DNA
Postdoctoral Associate Eunhee Yi has been awarded a $100,000 fellowship from the American Brain Tumor Association to discover how glioblastoma becomes so aggressive.
Press ReleaseSeptember 21, 2018
New way to target advanced breast cancers
New research shows that a cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.

Lab Staff

Li Hua, Ph.D.

Postdoctoral Associate

Stromal cells may provide a positive or negative role in modulating the immunotherapy.
Peishan Li, Ph.D.

Postdoctoral Associate

Dissecting the Roles of MSC and Adipocytes in Cancer Metastasis
Guangwen "Gary" Ren, Ph.D.

Assistant Professor

To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse.

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Open Positions

Job	Job Title	Location	Description

Selected Publications

View full list of publications