The Ren Lab
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
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OUR RESEARCH FOCUS
The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.
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Press ReleaseOctober 14, 2021JAX appoints first ever Chief Medical Officer, Jens Rueter
Jens Rueter, M.D. has been appointed the first ever chief medical officer of The Jackson Laboratory. Rueter is a practicing physician in Maine and has served as medical director of JAX’s Maine Cancer Genomics Initiative (MCGI) for the past five years. -
Research HighlightOctober 05, 2021Discovering how to prevent aging and cancer in the blood cell system
Jennifer Trowbridge of JAX seeks to thwart the mutations and inflammation that accumulate in aging bone marrow to maintain production of healthy blood cells and reduce blood cancer risk. -
Press ReleaseSeptember 23, 2021Innovation awarded to a ‘scientist’s scientist’
James Keck has been recognized as JAX President’s Innovation Fellow for inventions to accelerate drug development. -
Search MagazineSeptember 08, 2021Researching why and how we age
The Nathan Shock Centers of Excellence is empowering innovative approaches to aging research.
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Search MagazineOctober 06, 2021A lifelong friendship inspires support for JAX blood cancer research
A lifelong friendship inspires support for JAX blood cancer research. -
Research HighlightSeptember 30, 2021JAX research team examines how glioma cells handle stress
Gliomas, malignant brain tumors, are considered incurable by current science. What, then, makes them so adaptable and dangerous? A JAX research team featuring Kevin Johnson, Kevin Anderson, and Roel Verhaak use single-cell genetics to examine how gliomas handle stress so well. -
Featured ArticleSeptember 09, 2021Programming CKB: bringing clinical expertise to the world
Dan Durkin, technical team lead on the Clinical Knowledgebase (CKB), gives a first hand explanation of this powerful tool (available to anyone) that allows clinicians and researchers to better interpret complex cancer genomic profiles. -
Search MagazineSeptember 08, 2021Aging and immune function: a weakening line of defense
Why do we become ever more susceptible to various diseases over time? And do we all age in the same way, or are there differences?