The Ren Lab
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
Principal Investigator
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OUR RESEARCH FOCUS
The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.
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Research HighlightApril 23, 2024Investigating age-related immune dysfunction in lung epithelial cells
With $13 million in renewed support, Karolina Palucka will further study how aging affects airway epithelial cells’ efficiency in combating viral infections. -
Press ReleaseDecember 19, 2023JAX's 2023 achievements
JAX is celebrating important research breakthroughs, new faculty and leadership appointments, and crucial advancements in legislation. -
Research HighlightNovember 07, 2023Uniting the worlds of biomedical engineering, immunology, and microbiology
Assistant Professor Sasan Jalili unites the worlds of biomedical engineering, immunology, and microbiology, offering fresh insights into the intricate interactions between the human immune system and microbiome. -
Research HighlightOctober 23, 2023Examining the nongenetic drivers of acute leukemia drug resistance
Research from Eric Wang examines how nongenetic mechanisms of cancer development may represent therapeutic vulnerabilities that can be exploited to overcome drug resistance in acute myeloid leukemia and acute lymphoblastic leukemia.
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Press ReleaseMarch 11, 2024JAX and LG AI Research partner to pioneer biomedical advancements
Two world-leading organizations are partnering to further expand AI capabilities in biomedical science and catalyze medical progress. -
Research HighlightNovember 28, 2023Focusing on mitochondria
A. Phillip West, Ph.D., investigates mitochondria, with a focus on their roles in immunity and contributions to disease. -
Featured ArticleNovember 07, 2023The state of biomedicine presented at the Biomedical Innovation and Technology Conference
The current state of biomedicine and its potential for the future in Maine and beyond as presented in the inaugural Biomedical Innovation and Technology (BIT) Conference. -
Research HighlightOctober 20, 2023Exposing a master regulator of cancer treatment induced ovarian failure
New findings into a master regulator of cancer treatment–induced ovarian failure and infertility have opened up potential therapeutic avenues for treatments to preserve a woman’s long-term ovarian function.