The Ren Lab
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
Principal Investigator
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OUR RESEARCH FOCUS
The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.
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Research HighlightMay 23, 2023Two JAX researchers win Outstanding Paper Prize
Jennifer Sargent and Mark Warner have won a major publication award, highlighting their work with PDX. -
Research HighlightMarch 14, 2023How does inflammation and aging tie to the AP-1 Complex?
JAX researchers reveal proteins from two families are consistently activated and likely play a role in promoting chronic inflammation with age. -
Research HighlightFebruary 22, 2023Examining hematopoietic stem cells decline with age
In a new paper, Jennifer Trowbridge presents the factors and processes that contribute to Hematopoietic stem cells decline with age. -
Press ReleaseJanuary 24, 2023Jennifer Trowbridge receives award from The Mark Foundation for Cancer Research
Trowbridge has been recognized as an outstanding early-career scientist and will receive a $750,000 award.
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Blog PostMay 04, 2023Advancing cancer research with the latest therapies
Improving cancer patient outcomes depends on expanding our understanding of basic cancer biology as well as improving patient access to the latest therapies. -
Research HighlightFebruary 23, 2023Investigating the roles of mesenchymal cells in lung metastasis of breast cancer
Research from the Ren Lab examines the roles for mesenchymal cells in lung metastasis of breast cancer. -
Research HighlightJanuary 27, 2023Improving iPSC research with new cell lines
A stable iPSC line, KOLF2.1J, has been established to act as a high-quality baseline platform for modeling human disease. -
Research HighlightDecember 20, 2022Revealing the biology of senescent cells
JAX is playing a major role to bridge experimental mouse and human data and reveal the biology of senescent cells.