To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.
I am investigating the links between splicing and epigenetics marks during aging and cancer
Join us for our next Humanized Mice Journal Club where we will discuss experimental immune response to human melanomas with...
Join us as we discuss a new onco-hu model of ER+, ESR1-mutant, endocrine-resistant metastatic breast cancer.
To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse
Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.
Studying the mechanisms of human immunity and developing cancer immunotherapies.
It’s been long recognized that aging is the single biggest risk factor for cancer and that age impacts treatment response. Research is...
Currently researching the microenvironment of breast cancer, in order to develop new strategies of immunotherapy.
Metastatic cancer is the most dangerous and remains the most lethal.
New JAX research shows that inhibiting neutrophil lipid accumulation could provide a valuable anti-metastatic therapy target for cancer...
Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status
The National Cancer Institute has awarded Jackson Laboratory cancer researcher Gary Ren a five-year grant totaling...
The JAX Scholar award offers exceptional early-career scientists the opportunity to develop their independent research program at The...
Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.
Conducts research to understand how vaccines work and to define precisely the immune mechanisms that underlie vaccination, with a focus on...