The Ren Lab

To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse

Principal Investigator

Guangwen "Gary" Ren, Ph.D.

Location

Bar Harbor, ME

Contact

207-288-6000

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OUR RESEARCH FOCUS

The Ren group mainly focuses on elucidating how mesenchymal lineage cells (mesenchymal stem cells and fibroblasts) and immune-regulatory myeloid cells (neutrophils and macrophages) modulate the adaptive immune responses in cancer treatment resistance and metastatic relapse. These studies will fully take advantage of the unique research platform--patient-derived xenograft (PDX) tumors in humanized mouse models at The Jackson Laboratory, with the research goal to develop novel strategies targeting tumor microenvironment to improve the efficacies of conventional cancer therapies and new therapeutics such as immunotherapy.

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The Jackson Laboratory Cancer Center