The Bloss Lab leverages high resolution imaging strategies with activity and genetic perturbations of specific neurons in behaving mice to define how the synaptic architecture of neural circuits supports goal-directed behavior.
The brain is the most powerful computational device known. How do connections between brain cell support these functions? Our past work has demonstrated that genetically or anatomically defined neurons are connected in remarkably precise ways, promoting certain computations over others. The overarching goal of present work in the lab is to discover how these wiring patterns are shaped by experience or disease, and how they relate to learning and memory function. We use advanced imaging techniques to define synaptic connectivity between specific cell types. We also use viral, genetic, and chemogenetic strategies to relate activity patterns or molecules in specific cell types to the behavioral performance of mice in goal-directed tasks. Collaborations within and outside The Jackson Laboratory will allow us to leverage our neuroanatomical and genetic strengths with additional techniques to identify the broader principles by which cognition emerges from underlying brain circuitry.
Understanding how we use our brain to make decisions is a daunting task, given our brain's extensive webs of neural wiring and circuitry....
We take a look at the history of genomic sequencing, where it's going in the future, and the power it has to potentially treat diseases...
Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s disease is a devastating and rapidly fatal disease with currently only one available,...
C57BL/6J from JAX is the most widely used inbred strain in research programs focused on finding genomic solutions for a wide range of...
The Jackson Laboratory’s Bar Harbor campus was home base for the Roux Institute at Northeastern University’s Biotechnology Applied Lab...
JAX Professor Peter Robinson has spearheaded an effort to make phenotypic data (a collection of our traits) accessible and computable...
I'm interested in mitochondrial translation defects in neurons and how it leads to neurodegenerative diseases like Charcot-Marie-Tooth...
Researchers at The Jackson Laboratory have discovered that mutations in the gene that produces tRNAs in the nervous system result in...
Just a few years ago, epilepsy’s mysteries made it appear intractable. But now, thanks to new data and new research methods, there’s real...
Consider this scenario: Jayne is 50 years old and has experienced progressing neurological symptoms over the past two years with no...
The Bloss Lab uses various genetic, structural and functional approaches to understand how synaptic connectivity among cortical cell types...
Administrative support to research faculty and their lab personnel
A spotlight profile of Martine Seignon, a research data analyst specializing in data visualization in the Single Cell Biology Laboratory...