The Bloss Lab
The Bloss Lab leverages high resolution imaging strategies with activity and genetic perturbations of specific neurons in behaving mice to define how the synaptic architecture of neural circuits supports goal-directed behavior.
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The brain is the most powerful computational device known. How do connections between brain cell support these functions? Our past work has demonstrated that genetically or anatomically defined neurons are connected in remarkably precise ways, promoting certain computations over others. The overarching goal of present work in the lab is to discover how these wiring patterns are shaped by experience or disease, and how they relate to learning and memory function. We use advanced imaging techniques to define synaptic connectivity between specific cell types. We also use viral, genetic, and chemogenetic strategies to relate activity patterns or molecules in specific cell types to the behavioral performance of mice in goal-directed tasks. Collaborations within and outside The Jackson Laboratory will allow us to leverage our neuroanatomical and genetic strengths with additional techniques to identify the broader principles by which cognition emerges from underlying brain circuitry.
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Blog PostJune 22, 2022The progress of genetic sequencing
We take a look at the history of genomic sequencing, where it's going in the future, and the power it has to potentially treat diseases like cancer. -
Featured ArticleMay 05, 2022Ryan Tewhey: Genome explorer
JAX's Ryan Tewhey brings open-minded inquiry to the search for genetic mechanisms involved in complex traits and disease mechanisms. -
Research HighlightMay 05, 2022Investigating the non-coding genome
Ryan Tewhey, Ph.D., is leading efforts to apply high-throughput analyses to understand both how non-coding genome regulation works and its many roles in disease. -
Press ReleaseMay 03, 2022JAX announces 2022 recipients of the JAX Scholar awards
The Jackson Laboratory is proud to announce the 2022 recipients of the JAX Postdoctoral Scholar award. Eric Bogenschutz, Jayna Mistry, and Kwondo Kim represent forward-thinking research, proven leadership, and engagement with the scientific community.
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Research HighlightJune 15, 2022Unlocking clinical phenotype data
JAX Professor Peter Robinson has spearheaded an effort to make phenotypic data (a collection of our traits) accessible and computable across platforms. The result, called the Phenopacket schema, is now freely available. -
Press ReleaseMay 05, 2022JAX and the Roux Institute are building a biotech workforce
The Jackson Laboratory’s Bar Harbor campus was home base for the Roux Institute at Northeastern University’s Biotechnology Applied Lab course. Trainees in attendance are Master of Science in Biotechnology students at the Roux Institute. -
Featured ArticleMay 04, 2022Putting machine learning to work for cancer patients
A research team at JAX is boosting the speed and accuracy of tumor sample image analysis, for multiple cancer types, offering the potential for more targeted treatment direction without additional testing. -
Profile StoryApril 27, 2022Data analyst visualizes life inside cells
A spotlight profile of Martine Seignon, a research data analyst specializing in data visualization in the Single Cell Biology Laboratory based at The Jackson Laboratory for Genomic Medicine in Farmington, Conn.