The Bloss Lab leverages high resolution imaging, observation and manipulation of in vivo neural activity, and genetic perturbations in specific neurons to define how neural circuits supports goal-directed behavior.
The brain is a powerful computational device, yet we understand very little about the mechanisms it uses to produce cognition. Our past work demonstrated that genetically or anatomically defined neurons are connected in remarkably precise ways, promoting certain forms of circuit computations over others. Exactly how these precise wiring patterns and the resulting computations they support become altered by experience (e.g., learning) or by disease (e.g., Alzheimer’s disease) remains unknown. We use advanced imaging techniques to define synaptic connectivity between specific cell types. We pair this approach with viral, genetic, chemogenetic, and in vivo imaging strategies to relate the structural or functional features of specific cell types to the behavioral performance of mice in goal-directed tasks. Collaborations within and outside of JAX seek to identify the broader principles by which cognition emerges from underlying brain circuitry in health and disease states.
Involved in revealing genetic architecture and phenotypic spectrum of Cerebral Palsy.
A generous gift from Ray Sproats will support research into using human stem cells to treat age-related eye disease.
The Jackson Laboratory is proud to announce Lisa Wren, Ph.D., and Michael MacLean, Ph.D., as the 2023 JAX Scholars.
JAX is playing a major role to bridge experimental mouse and human data and reveal the biology of senescent cells.
Cat Lutz is on a group whose research examines TDP-43 and its effect on stathmin-2.
Develops algorithms and software that applies Machine Learning and text mining techniques to analyses big data to enable...
Since its earliest days, JAX has welcomed and celebrated women in science. Here are five great examples.
Participants from Nigeria, Tunisia, Egypt, Mali, Senegal, DR Congo, Ghana and South Africa came to Bar Harbor to learn from talks at the...