The Bloss Lab

The Bloss Lab leverages high resolution imaging strategies with activity and genetic perturbations of specific neurons in behaving mice to define how the synaptic architecture of neural circuits supports goal-directed behavior.

The brain is the most powerful computational device known. How do connections between brain cell support these functions? Our past work has demonstrated that genetically or anatomically defined neurons are connected in remarkably precise ways, promoting certain computations over others. The overarching goal of present work in the lab is to discover how these wiring patterns are shaped by experience or disease, and how they relate to learning and memory function. We use advanced imaging techniques to define synaptic connectivity between specific cell types. We also use viral, genetic, and chemogenetic strategies to relate activity patterns or molecules in specific cell types to the behavioral performance of mice in goal-directed tasks. Collaborations within and outside The Jackson Laboratory will allow us to leverage our neuroanatomical and genetic strengths with additional techniques to identify the broader principles by which cognition emerges from underlying brain circuitry.