Ewelina Bolcun-Filas, Ph.D.

Assistant Professor

Researching meiosis, the mechanisms of DNA damage detection and repair during normal development of gametes, and implications for fertility of cancer patients after radiation and chemotherapy.

Visit The Bolcun-Filas Lab

Location

Bar Harbor, ME

Contact

207-288-6000

Connect

More by @ewelinabolcunf

Recent Tweets

  • Ewelina Bolcun-Filas
    My favorite osprey couple did great! they are proud parents to be of 3 eggs! So excited for the chicks hatching in about a month. Fun fact: Osprey mate for life. #reprorocks t.co/s382OKrXkx
  • Ewelina Bolcun-Filas
    RT @jacksonlab: The Dumont lab recently published a paper outlining the diversity of centromere satellite architecture across mouse species…

Germ cells are the only cell type that must endure extensive DNA damage in the form of programmed meiotic double-strand breaks (DSBs) during their normal development. Paradoxically, the absence of DSBs during meiosis as well as persisting unrepaired breaks are detrimental and typically result in meiotic arrest and infertility. Our research aims to understand the molecular mechanisms controlling the development of healthy gametes and how misregulation of these mechanisms can lead to reproductive disorders. In particular, we are interested in meiotic “quality checkpoints” operating in germ cells, which ensure that the correct and intact genetic information is transmitted to the next generation. The same checkpoint that monitors DSB repair during meiosis is responsible for high sensitivity of oocytes to cancer treatment. Chemo and radiation therapies can cause oocyte death and lead to premature ovarian failure and infertility. Disabling the key checkpoint kinase CHK2 preserved fertility in mice exposed to ionizing radiation, thus opening a new avenue for oncofertility research. Our goal is to further dissect the DNA damage response pathway in oocytes, helping identify additional targets for fertility preservation therapies in cancer patients.

Education and experience

Education

2008-2013
Postdoctoral associate
Department of Biomedical Sciences, Cornell University, Ithaca, NY
Adv: John Schimenti

2004-2008
Postdoctoral fellow
MRC Human Genetics Unit, Edinburgh, UK
Adv: Howard Cooke

2001-2004
Ph.D., developmental biology
Georg-August-Universitat, Institut fur Humangenetik, Gottingen, Germany
Adv: Wolfgang Engel

1995-2000
M.Sc., biology
Jagiellonian University, Krakow, Poland
Adv: Jozefa Styrna

Experience

2015-
Assistant Professor
The Jackson Laboratory, Bar Harbor, ME

2013-2014
Research Scientist
Department of Biomedical Sciences, Cornell University,
Ithaca, NY

Grants, honors, and accomplishments

2004-2008
MRC Career Development Fellowship

1999-2000
IAESTE student exchange program at Georg-August-Universitat, Institut fur Humangenetik, Gottingen, Germany