My research goal is to elucidate how changes in gene expression regulation contribute to cancer. My lab focuses on characterizing the role of alternative-splicing misregulation in breast and ovarian cancer by using 3D cell culture and PDX models. Our unique expertise in both RNA biology and cancer research allows us to connect these distinct fields, and by combining innovative tools and interdisciplinary approaches, to gain novel insights into the molecular mechanism of gene expression regulation in normal and cancer cells. My research findings should lead to the development of novel biomarkers and promising drugs for cancer therapy.
Anczuków O and Krainer AR (2016). Splicing-factor alterations in cancers. RNA, 22:1285-301, 2016.
Anczuków O, Akerman M, Cléry A, Wu J, Shen C, Shirole NH, Raimer A, Sun S, Jensen MA, Hua Y, Allain FH, Krainer AR. SRSF1-Regulated Alternative Splicing in Breast Cancer. Molecular Cell. 60(1):105-17, 2015.
Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol. 19(2):220-8, 2012.
Anczuków O, Buisson M, Léoné M, Coutanson C, Lasset C, Calender A, Sinilnikova OM, Mazoyer S. BRCA2 deep intronic mutation causing activation of a cryptic exon: opening toward a new preventive therapeutic strategy. Clin Cancer Res. 18(18):4903-9, 2012.
Cholesterol-rich diet exacerbates mammary cancer progression and metastasis in a transgenic breast cancer mouse model.
Scientists are finding cancer's vulnerabilities—and how to attack them—by using patients' own cancers in the laboratory.
The Mouse Tumor Biology Database provides data about spontaneous and induced tumors from genetically defined mice.
Learn how not all C3H substrains have a high incidence of mammary tumors.
Mary-Claire King’s life and work serves as an ideal for scientific investigation and using our knowledge to empower...
Investigates how RNA splicing contributes to breast and ovarian cancer progression, metastasis and drug-resistance.
Uses mathematical algorithms to model and simulate molecular networks.
Researching the fundamental genomics of breast cancer.
Patient and family genetic resources
Factsheet summarizing screening guidelines for patients at average, increased, and high genetic breast cancer risk.
The Breast Cancer Genetics Referral Screening Tool is designed to quickly identify which patients should be referred for...
Breast cancer resources for healthcare providers.
CME program for primary care providers about hereditary breast and ovarian cancer syndrome
Key features and cancer risks associated with common hereditary cancer syndromes.
Factsheet about the clinical aspects of hereditary breast and ovarian cancer syndrome.
Lists the key points to communicate in informed consent.