The Unutmaz Lab investigates the biology of the human immune system.
Our research focus
Our research primarily focuses on decoding the differentiation, activation and regulation of human T cells for optimal immune responses to infectious diseases and their perturbations during chronic diseases or aging. We have contributed to the understanding of how T cell subsets are disrupted during human diseases, especially during HIV infection. Our lab has made several seminal discoveries about the diversity and mechanisms of immune suppression mediated by regulatory T cells and effector functions of human Th17 cell subsets.
Derya Unutmaz, M.D., will receive five years of funding totaling $3,281,515 from the National Institute of Allergy and Infectious Diseases to find better ways to diagnose and treat myalgic encephalomyelitis and chronic fatigue syndrome (ME/CFS).
JAX researchers have demonstrated the ability to target and disrupt specific genes and/or alter their expression levels, which has important implications for both immunology research and clinical treatments.