Gareth Howell, Ph.D.

Associate Professor, Diana Davis Spencer Foundation Chair for Glaucoma Research

Applies genetics and genomics approaches to study age-related neurodegeneration associated with Alzheimer’s disease, dementia and glaucoma.

In the Howell lab, we apply genetics and genomics approaches to identify fundamental processes involved in the initiation and early propagation of age-related neurodegenerative diseases, focusing on Alzheimer's disease, non-Alzheimer's dementia and glaucoma. Understanding these processes provides the greatest opportunity of therapeutic intervention. We are particularly interested in the role of non-neuronal cells including astrocytes, monocyte-derived cells (such as microglia), endothelial cells and pericytes.

In previous work, I applied novel genomics and bioinformatics strategies to identify new molecular stages of glaucoma that preceded morphological changes. Genetic knockout and/or pharmaceutical approaches showed that targeting the complement cascade and endothelin system significantly lessened glaucomatous neurodegeneration in mice. Our work with glaucoma continues in collaboration with Dr. Simon John, and we are also now applying similar genetics and genomics strategies to understand initiating and early stages of Alzheimer's disease, vascular dementia and other dementias. A major aim is to combine knowledge from human genetic studies with the strengths of mouse genetics to develop new and improved mouse models for dementias and make them readily available to scientific community.

Education and experience

Education

The Sanger Institute
Ph.D., comparative genome mapping
2002

University of Manchester
B.Sc., molecular biology
1993

Experience

The Jackson Laboratory
Assistant Professor
2012-present

The Jackson Laboratory
Research Scientist
2005-2010

The University of Sheffield, Sheffield
Postdoctoral Fellow, Wilson/Placzek Lab
2005

The Jackson Laboratory
Postdoctoral Fellow, Schimenti Lab
2003-2004

The Sanger Institute
Project Leader of Experimental Gene Annotation Group
2000-2002

The Sanger Institute
Research Assistant in the X Chromosome Mapping Group
1993-2000

Grants, Honors, and Accomplishments

The Schaffer Prize for Innovative Research
Glaucoma Research Foundation
2013

Barbara and Joseph Cohen Young Investigator Award
2007