Vivek Kumar, Ph.D.

Assistant Professor

Researches behavior and behavioral abnormalities, including addiction, ADHD and depression, using mouse genetics as a platform.

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About Vivek Kumar, Ph.D.

The Kumar lab studies neural circuits in the brain whose misregulation leads to behavioral abnormalities including addiction, attention deficit and hyperactivity disorder,and depression. Using mouse molecular genetics as a foundation, and a combination of biochemistry, physiology, and imaging techniques, we dissect these complex behaviors in mammals.

We use two functional genomics approaches in mice—forward genetic ethylnitrosourea (ENU) mutagenesis screens and quantitative trait loci (QTL) analysis—to identify genes and pathways that regulate these behaviors. Powerful and unbiased, forward genetic approaches make no a priori assumptions and only require a clear, well-defined assay for gene discovery. We have used a high-throughput screening pipeline to discover mutants for cocaine response and open-field behavior. Using physical mapping followed by next-generation sequencing, we have identified novel genes and alleles that regulate cocaine response and anxiety-related behaviors.

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Selected Publications

Highlighted Abstract

The inbred mouse C57BL/6J is the reference strain for genome sequence and for most behavioral and physiological phenotypes. However, the International Knockout Mouse Consortium uses an embryonic stem cell line derived from a related C57BL/6N substrain. We found that C57BL/6N has a lower acute and sensitized response to cocaine and methamphetamine. We mapped a single causative locus and identified a nonsynonymous mutation of serine to phenylalanine (S968F) in Cytoplasmic FMRP interacting protein 2 (Cyfip2) as the causative variant. The S968F mutation destabilizes CYFIP2, and deletion of the C57BL/6N mutant allele leads to acute and sensitized cocaine-response phenotypes. We propose that CYFIP2 is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior.

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Press ReleaseJuly 28, 2020
Building better mouse models for addiction research
NIDA grant to Vivek Kumar of JAX will fund development of new preclinical models of addiction.
Search MagazineMay 22, 2019
JAX scientists speak out on the crisis of opioid addiction
JAX scientists are intensifying their efforts to shed light on the genetic and neurobiological causes of addiction, along with the impact of environmental influences.
Research HighlightDecember 01, 2016
Discovering the genetic basis of sleep regulation
Researchers at JAX and the University of Texas Southwestern Medical Center have identified two genes that play significant roles in maintaining regular sleep.
Blog PostJune 06, 2016
Former opioid users are at a greater risk of overdosing than the newly addicted
JAX Associate Professor Vivek Kumar, Ph.D., explains why opioid users who have recently been released from prison or those who have already detoxed are more likely to overdose than new drug users.

Press ReleaseJuly 10, 2019
How do sleep and social interaction affect addiction?
Innovative AI technology captures mouse sleep and social behaviors for the study of their influence on drug intake and addiction.
- Addiction
- Behavioral Disorders
Featured ArticleSeptember 20, 2018
Discovering new addiction genes
Assistant Professor Vivek Kumar, Ph.D. gave a TED-style talk on addiction as part of the Laboratory’s JAXtaposition speaker series.
Press ReleaseJune 20, 2016
$3.4M grant from National Institute on Drug Abuse for Jackson Laboratory addiction study
JAX Assistant Professor Vivek Kumar will use the five-year grant to pinpoint genetic variants that increase susceptibility to addiction.
Blog PostFebruary 03, 2016
The key to addressing the addiction epidemic begins with science
Addiction is a chronic illness, with genetic, environmental and social aspects that are similar in scope to illnesses such as diabetes. Why should one be treated as a social and moral failure while the other is a medical issue?