Gregory Carter, Ph.D.
Professor, The Bernard and Lusia Milch Endowed Chair
Develops computational strategies using genetic data to understand complex genetic systems involving multiple genes and environmental factors.
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Recent Tweets
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Letters of recommendation are rarely useful. They usually communicate more about the writer than the subject, and this is often intentional. t.co/vSlBMK51k4 -
@jdavidjentsch What a great buddy. Very sorry for your loss.
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RT @JAX_Education: Dan Cortes-Perez, M.D., Ph.D., @jacksonlab postdoc turned associate research scientist in the @martinperaJAX lab, is tak…
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@EsotericCD Pretty sure the first complex theme should be "mastery".
Contemporary technologies such as high-throughput genome sequencing now enable the measurement of biological systems with unprecedented scale, power and precision, creating the opportunity to decipher the genetics that underlie human diseases. The overall goal of our laboratory is to develop novel computational strategies that use these data to understand complex genetic systems in which multiple genes and environmental factors combine to affect biological outcomes. These methods aim to map complex genetic architecture and infer models that predict the outcomes of genetic and environmental variation. We derive network models of interacting genes, integrate disparate phenotypic and molecular data types, critically evaluate models with experimental tests, and seek to understand how biological information is encoded in genetic networks and genomic data.
Grants, honors and accomplishments
The IU/JAX/Pitt MODEL-AD Center
Principal Investigator and Head of Bioinformatics and Data Management
NIA U54 AG054345, 2016-2027
Generation, Characterization, and Validation of Marmoset Models of Alzheimer’s Disease (Marmo-AD)
Program Director/Principal Investigator and Head of Bioinformatics and Data Integration
NIA U19 AG074866, 2022-2027
The Open Drug Discovery Center for Alzheimer’s Disease (TREAT-AD)
Principal Investigator and Head of Bioinformatics
NIA U54 AG065187, 2019-2024
Modeling the Genetic Interaction Between Klotho and APOE Alleles in Alzheimer's Disease
Principal Investigator
NIA RF1 AG075701, 2022-2027
Determining Genetic Interactors of Apolipoprotein E in Alzheimer’s disease
Principal Investigator
NIA RF1 AG055104, 2018-2023
Identification of Genetic and Genomic Variants by Next-Gen Sequencing in Nonhuman Animal Models
Co-Investigator
NIDA U01 DA051235, 2021-2026
Full Human Gene Replacement Mouse Models of Alzheimer's Disease
Co-Investigator
NIA RF1 AG079125, 2022-2027
Cancer Center Support
Co-Project Lead
NCI P30 CA034196, 2020-2025
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Press ReleaseDecember 19, 2022An outstanding year of growth at The Jackson Laboratory
2022 has been a notable year for The Jackson Laboratory, with great achievements and many reasons to celebrate continued momentum for JAX’s mission. -
Press ReleaseMarch 12, 2021Three new endowed chairs to lead Alzheimer’s, addiction, and cancer research
The Jackson Laboratory (JAX) has appointed three faculty members to endowed chairs in order to further research into Alzheimer’s disease, addiction, cancer and computational biology. -
Research HighlightJune 04, 2020Multiple paths lead to the same destination in Alzheimer's disease
Working with human patient data, a research team led by JAX Associate Professor Greg Carter and summer student Nikhil Milind have identified two distinct subtypes, inflammatory and non-inflammatory, of Alzheimer’s disease. The finding provides important insights for identifying disease biomarkers and therapeutic targets. -
Press ReleaseJuly 23, 2018Eight new mouse models for Alzheimer’s disease available to researchers
Indiana University-Jackson Laboratory MODEL-AD Center addresses critical need for precision animal models for Alzheimer’s research.
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Research HighlightMarch 30, 2022JAX is shedding light on new treatments for eye disease
JAX Professor Patsy Nishina and her colleagues have developed mouse models for translational vision research that are now available to the wider biomedical research community. -
Research HighlightSeptember 22, 2020Finding ways to TREAT Alzheimer's disease
The quest to find a cure for Alzheimer’s disease (AD) has almost entirely met with failure at the clinical trial stage. Nonetheless, there have been research advances, particularly during the last few years, that are laying the foundation for progress in the years ahead. -
Research HighlightFebruary 06, 2019JAX collaboration yields important implications for data science
A paper published in Molecular Biology of the Cell leads to important implications for both reproductive biology and data science. -
Press ReleaseJuly 13, 2018New research effort to understand role of APOE mutation in Alzheimer’s disease
Inheriting a specific genetic variant, APOEε4, is linked with 15-20 percent rise in risk of developing Alzheimer’s, with at least 20 other genes implicated. JAX researchers are studying how APOEε4 risk depends on other genes, in mice with a wide variety of genetic backgrounds.