Gregory Carter, Ph.D.

Associate Professor, The Bernard and Lusia Milch Endowed Chair

Develops computational strategies using genetic data to understand complex genetic systems involving multiple genes and environmental factors.

Contemporary technologies such as high-throughput genome sequencing now enable the measurement of biological systems with unprecedented scale, power and precision, creating the opportunity to decipher the genetics that underlie human diseases. The overall goal of our laboratory is to develop novel computational strategies that use these data to understand complex genetic systems in which multiple genes and environmental factors combine to affect biological outcomes. These methods aim to map complex genetic architecture and infer models that predict the outcomes of genetic and environmental variation. We derive network models of interacting genes, integrate disparate phenotypic and molecular data types, critically evaluate models with experimental tests, and seek to understand how biological information is encoded in genetic networks and genomic data.

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Grants, honors and accomplishments

Grants and Honors

2019-2024 - Co-Investigator and Bioinformatics Core Lead, Emory/Sage/SGC Target Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT-AD) Center, NIH/NIA U54 AG065187.

2018-2023 - Principal Investigator, Determining Genetic Interactors of Apolipoprotein E in Alzheimer’s Disease, NIH/NIA RF1

2017-2022 - Principal Investigator, Identifying Shared Pathogenic Networks and Molecular Targets Underlying Retinal Pigmented Epithelial Associated Disease, NEI R01 EY027860

2017-2022 - Co-Investigator, Systems Genetics of Resilience to Alzheimer’s Disease, NIA R01 AG057914

2016-2021 - Principal Investigator and Head of Bioinformatics and Data Management, IU/JAX Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease (MODEL-AD), NIA U54 AG054345.

2016-2021 - Principal Investigator, Methods and Tools to Analyze Genetic Complexity, NIGMS R01 GM115518. GRANTS, HONORS, AND

Accomplishments

2019-2024 - Co-Investigator and Bioinformatics Core Lead, Emory/Sage/SGC Target Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT-AD) Center, NIH/NIA U54 AG065187.

2018-2023 - Principal Investigator, Determining Genetic Interactors of Apolipoprotein E in Alzheimer’s Disease, NIH/NIA RF1

2017-2022 - Principal Investigator, Identifying Shared Pathogenic Networks and Molecular Targets Underlying Retinal Pigmented Epithelial Associated Disease, NEI R01 EY027860

2017-2022 - Co-Investigator, Systems Genetics of Resilience to Alzheimer’s Disease, NIA R01 AG057914

2016-2021 - Principal Investigator and Head of Bioinformatics and Data Management, IU/JAX Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease (MODEL-AD), NIA U54 AG054345.

2016-2021 - Principal Investigator, Methods and Tools to Analyze Genetic Complexity, NIGMS R01 GM115518.