Develops algorithms and software for the analysis of exome and genome sequences.
The Robinson Lab is primarily located at The Jackson Laboratory. Together with the Phenomics Team, our group develops the Human Phenotype Ontology and applications of this ontology to differential diagnostics and genomics analyses.
We develop algorithms for exome and genome sequencing, ChIP-seq, immunogenomics, and other genomics applications, Gene Ontology analysis, computational phenotype analysis, as well as various algorithms from the fields of Machine Learning and modeling of biological networks with the tools of linear algebra and graph theory. We also collaborate on the computational analysis of wetlab biological data, especially in the fields of human hereditary disease and the molecular basis of bone development and fracture healing.
Zemojtel T, Köhler S, Mackenroth L, Jäger M, Hecht J, Krawitz P, Graul-Neumann L, Doelken S, Ehmke N, Spielmann M, Oien NC, Schweiger MR, Krüger U, Frommer G, Fischer B, Kornak U, Flöttmann R, Ardeshirdavani A, Moreau Y, Lewis SE, Haendel M, Smedley D, Horn D, Mundlos S, Robinson PN. Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome. Sci Transl Med 6:252ra123, 2014.
Brookes AJ, Robinson PN. Human genotype-phenotype databases: aims, challenges and opportunities. Nat Rev Genet 16:702-15, 2015.
Krawitz PM, Schweiger MR, Rödelsperger C, Marcelis C, Kölsch U, Meisel C, Stephani F, Kinoshita T, Murakami Y, Bauer S, Isau M, Fischer A, Dahl A, Kerick M, Hecht J, Köhler S, Jäger M, Grünhagen J, de Condor BJ, Doelken S, Brunner HG, Meinecke P, Passarge E, Thompson MD, Cole DE, Horn D, Roscioli T, Mundlos S, Robinson PN. Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nat Genet. 42:827-9, 2010.
Robinson PN, Köhler S, Oellrich A, Sanger Mouse Genetics Project, Wang K, Mungall C, Lewis SE, Washington N, Bauer S, Seelow D, Krawitz P, Gilissen C, Haendel M, Smedley D. Improved exome prioritization of disease genes through cross species phenotype comparison. Genome Res. 24:340–348, 2014.
Robinson PN, Köhler S, Bauer S, Seelow D, Horn D, Mundlos S. The Human Phenotype Ontology: a tool for annotating and analyzing human hereditary disease. Am J Hum Genet 83:610-5, 2008.
Modeling of transcription and its variation with extrinsic or intrinsic triggers.
I work on development of new algorithms designed to analyze big data to enable precision medicine
Researchers led by JAX Professor Peter Robinson, Ph.D., developed “Genomiser,” a new tool that combines machine learning and an algorithm...
Applies machine learning and text mining techniques to the analysis and curation of the Human Phenotype Ontology and other...
I develop tools to describe the phenotypic features of neurodevelopmental disorders and discover their associated genotypes.
Dr. Robinson is a computational biologist who develops bioinformatics resources and algorithms for translational research...
JAX professor calls for concerted effort to align data across patients and systems with comparable and consistent formats...
Develops algorithms and software for the analysis of exome and genome sequences.
Uncovering temporal dynamics of large collection of cells by applying machine learning and dynamical systems framework to...
Working on understanding the fundamental roles of the microbiome, particularly the skin and the gut microbiome.
Our Farmington campus is home to The Jackson Laboratory for Genomic Medicine. Researchers here focus on human genomics, complementing our...
Maintaining experimental mouse colonies is a lot like juggling. There are a lot of balls that you have to keep in the air all the time. You...
JAX is shaping the future of health, making it possible to use an individual’s unique genomic makeup to predict, treat, and...
In this intensive 2 1/2 day workshop, participants will be introduced to theory, experimental design, analysis and interpretation of...
Join us to expand your professional skills as you embark on a fulfilling science career.
Join us to expand your professional skills as you embark on a fulfilling science career.