My long‐term goal is to expand understanding of the metabolic interplay between tumor and immune cells, which will offer novel strategies for vaccines, drug development, disease prognosis and immunotherapy.
About Lucas Chang, Ph.D.
Metabolism is the set of biochemical reactions that occur within cells to sustain life. As such, metabolism, by definition, remains the single most fundamental force driving cell fate. Over the last several years there has been intense interest in how metabolic events in T cells and cancer cells dictate their cellular function, yet there is still relatively little data on this subject. I am interested in understanding the cellular and molecular mechanisms that control T cell fate and function during cancer development and infection. How does metabolism govern T cell dysfunction and tumor progression/metastasis in a local microenvironment? How do tumors and T cells utilize nutrients/metabolites to modulate their function, survival, and development? How are metabolism and gene expression coordinated through networks of mRNA, metabolic enzymes, and metabolites? My long-‐term goal is to provide detailed mechanistic understanding of metabolic interplay between tumor and immune cells, which will offer novel strategies for vaccines, drug development, disease prognosis, and immunotherapy.