The latest press releases from The Jackson Laboratory
Today researchers from The Jackson Laboratory for Genomic Medicine (JAX-GM), UConn Health, and Connecticut Children’s sent genetically-engineered “Mighty Mice” to the International Space Station to learn about the effect of microgravity on muscle and bone loss.
The American Association for the Advancement of Science (AAAS) has elected Jackson Laboratory Professor Gary Churchill as an AAAS Fellow, one of the nation's highest scientific distinctions.
The Glioma Longitudinal Analysis (GLASS) Consortium characterized diffuse glioma cells both before and after therapy to characterize how they change and why this form of malignant brain cancer is so difficult to treat. The findings provide a foundation for further research and the opportunity for the clinical community to predict the effectiveness of newly developed treatments.
Human somatic cell genome editing is a promising treatment option for cardiovascular disorders, but concerns remain about the safety and efficacy of this therapeutic strategy.
STAT taps Jackson Laboratory postdoc Amy Dunn for 2019 class of future science superstars.
The Jackson Laboratory collaborates with researchers in China to further understand and harness the genetic and biological complexity of disease to improve human health
The Howard Hughes Medical Institute has made a three-year grant to support JAX-GE advanced courses for talented graduate students, postdoctoral fellows and early-career faculty who will be future leaders in biomedical research and education.
The National Institutes of Health have contracted with a JAX team led by Bill Skarnes, professor and director of cellular engineering, to generate a collection of engineered iPSC brain cell lines for the National Institute on Aging.
Genetically diverse research animal models are key to understanding complex diseases.
National Institute on Aging makes $6.8 million grant for JAX research in cognitive aging.
$7.9 million grant to JAX scientists extend an important testing program for age-retarding agents
The National Eye Institute has made a four-year grant totaling $2,144,828 for continued funding for The Jackson Laboratory's Eye Mutant Resource.
JAX, UConn researchers explore how patients’ microbiome, and risk of infection, change after time in a skilled nursing facility.
JAX researcher's obesity research is focused on how the food we eat changes our brains, and how those changes influence how much food we eat.
New research by JAX Assistant Professor Adam Williams, published in Science, points the way to more precise allergy testing as well as identifying new approaches for treating allergy.
The Jackson Laboratory announces the recipients of its 2019 JAX College Scholarship: Shannon O’Roak of Exeter, Maine; Joanna Idrovo of Torrington, Connecticut; and Monserath Mendoza of Sacramento, California.
The 8th annual JAXfit 5k walk/run took place Saturday, July 13 to raise awareness in the local community about addiction.
Two new mouse models created to study neurological developments in Snyder-Robinson Syndrome to advance global understanding of this rare disease.
Innovative AI technology captures mouse sleep and social behaviors for the study of their influence on drug intake and addiction.
JAX has teamed with Lovelace Biomedical, Exemplar Genetics, Iontox and the University of Pennsylvania to win a new $17M contract with the NIH to provide new tools for advancing cures of rare and neglected diseases.
A new study published in Nature sets a new precedent for understanding the development of type 2 diabetes, and it provides a trove of data for ongoing research.
Researchers say that harnessing a specific immune response to prevent inflammation could prevent insulin resistance, cardiovascular disease.
A recent study used multiple advanced technologies to dive deeper into the human genome than ever before to comprehensively characterize the structural variants present in three families, and what their functional consequences might be.
Research led by the UConn School of Medicine and JAX shows that senescence, a cellular aging process, is associated with an aggressive form of multiple sclerosis (MS). The finding explains a mechanism for MS disease progression as well as indicating a promising avenue for therapy development.
Continuing The Jackson Laboratory’s (JAX) commitment to making a difference in STEM education and developing future scientists, JAX was the Life Sciences Major sponsor for the 2019 Connecticut Science and Engineering Fair (CSEF).
High school students presented their original research and engineering project to a state-wide audience of peers and mentors, in competition for coveted state titles and more than $548,000 in scholarships and awards.
In addition to exploring antiviral lung immune function, The Cooperative Center on Human Immunology will also investigate changes brought about by two diseases: adult lung cancer and childhood asthma.
Emaly Piecuch, Ph.D. and Jufen Zhu, Ph.D. performed their dissertation research at The Jackson Laboratory for Genomic Medicine in Farmington, Connecticut under the supervision of JAX Professor Yijun Ruan.
A collaborative team from UConn and The Jackson Laboratory have characterized neuron diversity in the lateral hypothalamic area (LHA), a critical coordinator of fundamental behaviors in the brain. The results provide important clues for understanding LHA neural circuits and the potential development of targeted neuropsychiatric therapies.
Crown Bioscience selects JAX to distribute MS-NASH, a model that more closely mirrors human disease development.
Supported by a recent four-year, $2.3M grant from the National Institute of General Medical Sciences, Wei is looking to develop a method for chromatin interaction analysis in single nuclei, with single-molecule resolution.
$2.8 million federal grant to The Jackson Laboratory (JAX) to understand the aging-related genomic changes in immune cells that affect responses to flu vaccines.
JAX has signed a research agreement for up to $4.2 million with Sanofi to identify new targets to treat triple-negative breast cancer and ovarian carcinoma.
The Clinical Genomics Laboratory will participate as an NCI-MATCH designated laboratory, helping to connect potentially eligible cancer patients at NCI-MATCH sites with clinical trials.
A team led by Jackson Laboratory Professor Yijun Ruan, Ph.D., has developed a new method, called ChIA-Drop, that allows researchers to investigate 3D genomic structures with unprecedented precision and clarity.
Representatives from the Bangor Savings Bank visited JAX headquarters to present their gift of $100,000 toward the Charles E. Hewett, Ph.D., Leadership Excellence Fund.
JAX’s Stitzel Laboratory secures funding from the National Institute of Diabetes and Digestive and Kidney Diseases that will allow them to explore a new genomic region linked to type 2 diabetes, with hopes of establishing them as new targets for treatment.
JAX Professors Roel Verhaak and Ching Lau are leading research programs into glioblastoma with awards from the National Cancer Institute as part of a large national research consortium.
Recent research suggests long non-coding RNAs (lncRNAs) contribute to immune dysfunction, and JAX Assistant Professor Adam Williams is investigating the roles they may play in asthma.
Tom Ellis will oversee the human resources and safety functions for the Laboratory.
Supported by a grant from the U.S. Department of Defense, Elise Courtois is researching the genetic mechanisms underlying endometriosis, a painful disease with no non-surgical treatment.
A new genetically diverse mouse population is opening possibilities for translational research into Alzheimer’s disease that accurately recreates human disease symptoms and progression.
JAX announces several key milestones in China that will help to empower the Chinese biomedical research community.
Armed with new funding from the V Foundation, Olga Anczuków-Camarda is uncovering genetic changes in the breast, paving the road to early cancer detection and prevention.
Using computer models, researchers have identified a potential new therapy that would reduce the long-term side effects of radiation therapy in pediatric brain cancer patients.
Abbott will lead the development of financial strategies, plans, and budgets, as well as continue to guide JAX’s financial services team.
Clinicians, translational researchers, academics, clinical lab personnel, and even patients may choose between three levels of access to best suit their needs.
DSCAM interacts with other cell adhesion molecules to prevent their running amok.
NIH awards $3.5M to JAX under multi-institution Somatic Cell Genome Editing program.
The National Institute on Drug Abuse has made a $4M grant to JAX scientists to explore the roles of the microbiome and genetics in substance use disorders.
$2.8 million Department of Defense grant will fund JAX research defining gene-environment interactions of islet resilience and type 2 diabetes
Postdoctoral Associate Eunhee Yi has been awarded a $100,000 fellowship from the American Brain Tumor Association to discover how glioblastoma becomes so aggressive.
New research shows that a cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
Next-generation anti-infectives designed to address the evolving issue of drug resistance.
A new approach to treating some leukemias could deliver a one-two punch to the cancer cells without harming normal tissue.
When an otherwise harmless fungus like Aspergillus fumigatus invades the lungs of people with compromised immune systems, it can cause severe respiratory problems. A new NIH grant will employ specialized mathematical and computer modeling to improve understanding of our biological defense system.
Travis Hinson, M.D., has received more than $2 million from the National Institutes of Health National Heart, Lung, and Blood Institute to study the mechanisms responsible for a serious and often fatal heart condition.
New five-year, $2.2M outstanding investigator grant to Mingyang Lu will support systems biology algorithm approach.
New $3.8M National Institute on Aging grant will fund JAX studies of hypothalamic dysfunction in Alzheimer’s.
The Jackson Laboratory has announced the promotion of Auro Nair, Ph.D., to Executive Vice President and Kenneth Fasman, Ph.D., to Senior Vice President for Research.
Indiana University-Jackson Laboratory MODEL-AD Center addresses critical need for precision animal models for Alzheimer’s research.
Inheriting a specific genetic variant, APOEε4, is linked with 15-20 percent rise in risk of developing Alzheimer’s, with at least 20 other genes implicated. JAX researchers are studying how APOEε4 risk depends on other genes, in mice with a wide variety of genetic backgrounds.
Gareth Howell named Diana Davis Spencer Foundation Chair for Glaucoma Research
The event kicks off The Jackson Laboratory's initiative to make Bar Harbor, Maine dementia-friendly.
June is Alzheimer’s & Brain Awareness Month, a time dedicated to increasing public awareness of Alzheimer’s disease, available resources and how you can get involved to support the cause.
JAX volunteers in three states volunteer to help families impacted by Alzheimer's disease.
A JAX research team led by Charles Lee has identified six significant copy number variations that are unique to patients with a severe birth defect.
A research team led by Chia-lin Wei is using technology to more easily detect and classify important types of difficult-to-find genomic alterations, known as structural variants.
Judith and Anthony Evnin, Ph.D., are giving $1.5 million to JAX to establish the Evnin Family Endowed Chair in Alzheimer’s Research. Catherine Kaczorowski, Ph.D., a JAX neuroscientist who is taking a bold approach to combat Alzheimer’s, has been appointed chairholder.
$10,000 JAX College Scholarship awarded to Norwich student.
New research is providing a better understanding of the processes underlying cell-to-cell differences within glioblastoma tumors — a crucial finding because these differences contribute to therapy resistance.
A Jackson Laboratory (JAX) research team led by Assistant Professor Duygu Ucar is among 85 teams to receive funding from the Chan Zuckerberg Initiative DAF, an advised find of Silicon Valley Community Foundation, to participate in the Human Cell Atlas project, a global, collaborative, multidisciplinary effort to catalog all the cells in the healthy human body.
First global online catalog of Patient-Derived Xenograft models helps cancer researchers save valuable time.
Michael Stitzel, Ph.D., a Jackson Laboratory assistant professor, is the senior author of a paper in the American Journal of Human Genetics identifying new genetic clues to type 2 diabetes mechanisms.
The JAX/Tufts CTSI collaboration will strengthen and expand research and training programs in clinical and translational science.
Honey Reddi was among the winners at the Connecticut Technology Council’s 2018 annual Women of Innovation Awards Gala in Plantsville, Connecticut, March 28.
The Alzheimer’s Association has awarded a three-year research fellowship to Amy Dunn, Ph.D., a postdoctoral associate in the Kaczorowski lab, for her studies of how genetics and diet interact to determine risk for Alzheimer’s disease.
As part of our commitment to make a difference in the communities where we live and work, The Jackson Laboratory (JAX) was a proud sponsor of the 70th Annual Connecticut Science and Engineering Fair (CSEF) that took place March 12-17 at Quinnipiac University.
Katy Longley will be promoted to executive vice president (EVP) and chief operating officer (COO) of the non-profit biomedical research institute.
The members of the American Association for Cancer Research have elected Jackson Laboratory President and CEO Edison T. Liu, M.D. to serve on the AACR Board of Directors for the 2018-2021 term.
Hicke was the former dean of the College of Natural Sciences and professor of molecular biosciences at the University of Texas at Austin.
JAX Professor Mary Ann Handel has been recognized by her peers for a career of science and service.
An Alzheimer's awareness event in Bangor was held to address the complexities of Alzheimer’s disease, to raise overall awareness, and to lend human voices to an immense public health problem.
Beginning his new role in March, Ryan will provide leadership and direction for all legal affairs of The Jackson Laboratory, including managing the legal department.
Maine Technology Institute awards Maine Technology Asset Funds to support Phase 2 of mouse vivarium construction.
Jackson Laboratory scientist conducts large-scale survey of cells from prediabetic, diabetic and normal patients to discover new treatments.
New funding and partnerships are helping JAX’s Molly Bogue accelerate progress in addiction research.
The Naggert lab has identified a genetic modifier that prevents the fragmentation of the external limiting membrane in two different mouse models models of enhanced S-cone syndrome and other diseases of the retina.
Single-cell characterization of non-myocyte heart cells offers new insights into the structure and function of the cardiac cellular landscape, including sex-based differences.
LuAnn Ballesteros has been promoted to vice president, external and government affairs, joining The Jackson Laboratory’s senior management team.
A grant from the National Human Genome Research Institute to JAX Assistant Professor Albert Cheng, Ph.D., will fund the creation of a molecular “toolkit” to explore the effects of epigenetic modifications
JAX Assistant Professor Catherine Kaczorowski, Ph.D., will receive a Young Investigator Award from the International Behavioural and Neural Genetics Society (IBANGS).
New minimal information standard makes patient-derived xenograft (PDX) models easy to find, access, integrate and reuse.
JAX, Rockefeller research team shows mice lacking Daple show developmental defects in hair cells and bundles.
New research has important implications for vaccine delivery, as the usual method, intramuscular injection, is likely not the most effective way to trigger our immune systems.
JAX online Disease Navigator tool will enable heart disease researchers to access genomic data shared by humans and animal models.
Chang studies cell metabolism in tumor and immune cells, with the aim of developing new treatment approaches for cancers and immunologic diseases.
New website provides unified access to comparative genetics and genomics data.
Research at Nationwide Children’s and The Jackson Laboratory will provide new strategies to protect young children from invasive infections.
National Cancer Institute awards $2M grant to fund joint PDX data center to integrate, share and analyze cancer treatment data for research community.
Five-year, $25 million grant distributed among nine research institutes in the United States.
Research in skin microorganisms could lead to better therapies for skin and infectious diseases.
Ke focuses on the role of RNA function in health and disease, including cancer.
Grant to JAX Professor Derya Unutmaz, M.D., part of multi-institutional research effort to understand and treat Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Research by Krish Kizhatil, Ph.D., could lay the groundwork for identifying more effective glaucoma treatments.
Mouse models for acute myeloid leukemia are available with a wide range of genetic mutations and growth profiles more closely mimic the human population.
Catherine Kaczorowski will use National Institute on Aging funding to seek targets for treatment and prevention of Alzheimer’s disease.
Jackson Laboratory (JAX) Assistant Professor Catherine Kaczorowski, Ph.D., has been recognized by The Glenn Foundation for Medical Research for her efforts toward gaining a better understanding of cognitive aging.
JAX scientists to explore genetic mechanisms in retinitis pigmentosa, other heritable retinal disorders.
New JAX assistant professor Ryan Tewhey, PhD., explores genetic variants that affect gene regulation.
BJ Bormann has joined nonprofit biomedical research institution, The Jackson Laboratory, as vice president, translational science and network alliances.
Zhengqing Ouyang will analyze role of RNA structure in neurological disorders, cancer and other diseases.
Research by Yanjiao Zhou will explore microbiome mechanisms leading to MS and preventive potential of intermittent fasting.
Research by Duygu Ucar will explore why our immune system deteriorates as we age.
A new five-year federal research grant totaling $3,322,009 to JAX Associate Professor Greg Cox will fund studies of a new mouse model for amyotrophic lateral sclerosis (ALS).
New collaboration expands access to leading-edge research capabilities to find new treatments for life-threatening diseases.
A JAX-led research team detects gene expression patterns distinct from those of the surrounding immune cells, and characterizes the effects of chemotherapy and radiation treatments.
Two subsets of dendritic cells work together to activate T cells against a virus, reports a research team led by JAX Professor Karolina Palucka
The sex of animals frequently has an effect in biomedical research and therefore should be considered in the study of science, report an international team of scientists including The Jackson Laboratory.
Crown Bioscience and The Jackson Laboratory have announced an agreement to improve the development and accessibility of innovative research models and preclinical services to the global biomedical research community.
Christine Beck, Ph.D., a genomics expert in transposable elements and their impact on human disease, will join The Jackson Laboratory for Genomic Medicine and UConn Health as their fifth joint-appointed faculty.
The prestigious 2017 ELSI Congress was hosted by UConn Health and The Jackson Laboratory for Genomic Medicine June 5-7 in Farmington, Conn.
Discoveries in JAX-founded Collaborative Cross, Diversity Outbred populations show value of multi-parent model organism systems
JAX researchers, collaborators block B-cell AID, prevent diabetes in non-obese diabetic mice
The institution signed on 315 employees and received $12.7 M in grants in 2016.
A five-year National Institute on Aging grant to JAX Assistant Professor Catherine Kaczorowski will fund genomic studies of healthy aging and Alzheimer’s disease.
Genomics and Society: Expanding the ELSI Universe is a three-day conference on the myriad issues that spring from the ethical, legal and social implications of genomic research.
In a paper published in Aging Cell, Jackson Laboratory Assistant Professor Ron Korstanje, Ph.D., Postdoctoral Fellow George Sutphin, Ph.D., and colleagues discovered 46 novel longevity-related genes and identified three genes that especially warrant further study.
Currently there are no effective cures for age-related macular degeneration and other heritable retinal diseases.
A select group of students will soon join the front lines of cutting-edge genetics research thanks to a new academic collaboration between The Jackson Laboratory and College of the Atlantic.
Specific genetic mutations in Charcot-Marie-Tooth disease that worsen peripheral nerve damage could be a helpful biomarker for predicting the severity of a given case of CMT.
A grant from the Human Frontier Science Program it JAX Professor Yijun Ruan will fund study of the role of the 3D genome in learning, memory and epilepsy
Winners will represent Maine at prestigious International Science Fair; scholarships from The University of Maine, College of the Atlantic, and University of Southern Maine awarded to promising high school scientists.
It's time to update the old “bench-to-bedside” shorthand, researchers at JAX, NHGRI and institutions across the U.S. declare.
The Maine Cancer Genomics Initiative has accomplished key milestones toward its mission of partnering with clinical institutions and oncology practices in Maine to help cancer patients across the state.
Single-cell signatures of colorectal tumors can provide more targeted diagnosis and treatment
Two grants from the U.S. Department of Defense totaling $2.8 million will support Jackson Laboratory (JAX) research in one of the most deadly forms of breast cancer, known as triple-negative breast cancer.
A two-year NIH grant to JAX totaling $455,000 will support research to improve the accuracy and efficiency of CRISPR-Cas9 genome editing.
Auro Nair, Ph.D., has been promoted to president of JAX® Mice, Clinical and Research Services.
M.D. Anderson Cancer Center and JAX Genomic Medicine begin clinical study using JAX ActionSeq Plus™ to identify additional treatment options for patients with cancers of unknown primary.
New research shows that simply adding vitamin B3 to the drinking water of mice predisposed to glaucoma can prevent the debilitating eye disease.
The National Human Genome Research Institute has awarded a grant totaling $6,727,904 over four years to JAX Professor Yijun Ruan to launch a center for the 3-D mapping of the human and mouse genomes.
Se-Jin Lee, M.D., Ph.D., will begin his role as Presidential Distinguished Professor at UConn School of Medicine and professor at The Jackson Laboratory this summer.
Cancer cells hijack a mechanism that enables stem cells and germ cells to continue dividing, by reactivating telomerase. A research team led by JAX Professor Roel Verhaak reports on the discovery that, in about 35 percent of cancers, TERT promoter methylation is the key to cancer cells' success in maintaining telomeres and surviving.
Genomics pioneer and bioinformatics expert Mark Adams, Ph.D. will enhance the The Jackson Laboratory’s large-scale microbiome initiatives.
Dozens of employees and dignitaries braved the frigid temperatures today to celebrate the ceremonial “topping out” of the new Center for Biometric Analysis at The Jackson Laboratory.
Grant funding will support Basile Tarchini’s studies into how defects in the architecture of sensory cells perceiving sounds cause hereditary hearing deficits.
Gregory Leet will lead global development, communications and trustee relations at JAX.
Edison T. Liu, M.D. of The Jackson Laboratory (JAX) has been named a Fellow of the American Association for the Advancement of Science (AAAS).
Three Connecticut research institutions are partnering with a prestigious counterpart in Israel to fill a research void that exists in the area of metabolic diseases, such as obesity and diabetes, which affect billions of people worldwide.
Caribou has granted JAX non-exclusive worldwide rights to use its CRISPR-Cas9 intellectual property to create genetically engineered mice for research purposes.
Baker explores the genetic and molecular regulatory system controlling the location and rate of meiotic recombination, the process that generates new genetic variation in sexually reproducing organisms.
Kaczorowski is a neuroscientist who works to identify early causative events that underlie cognitive deficits associated with normal aging and Alzheimer’s disease, has been appointed a Jackson Laboratory assistant professor.
Comprehensive suite of genome editing technologies will enable custom-made mouse models for studying human disease.
Joint appointment with Connecticut Children's Medical Center and the UConn School of Medicine will foster development of new genomic technologies for pediatric brain and bone cancers, create advanced treatments for patients.
A new grant from the National Institute of General Medical Sciences to Jackson Laboratory Associate Professor Greg Carter, Ph.D., will fund the development of new computational tools to analyze vast amounts of genomic data to understand how multiple genes interact in complex diseases.
Grant provides $25 million to develop new treatments, future therapies based on precision modeling.
The National Institute on Aging (NIA) has awarded a four-year, $2,348,313 grant to Jackson Laboratory (JAX) Professor Jacques Banchereau, Ph.D., to develop better prevention and treatment strategies for pneumococcal pneumonia in elderly people, who are at elevated risk for illness and death from the disease.
New research finds that of 1,751 genes characterized by the International Mouse Phenotyping Consortium to date, nearly one third are essential for life.
Jacqueline White, Ph.D., a scientific manager who has led large-scale laboratory animal operations in the United Kingdom, will direct The Jackson Laboratory’s (JAX) new Center for Biometric Analysis (CBA), now under construction on the institution’s Bar Harbor, Maine, headquarters campus.
JAX has entered into a sponsored research agreement with bioMérieux USA to develop more precise diagnostics for pathogens and their antimicrobial resistances in infectious diseases.
A grant of $225,000 from the Maximilian E. & Marion O. Hoffman Foundation, Inc., will provide funding to support a postdoctoral fellow at The Jackson Laboratory.
The Jackson Laboratory and Shoreline Biome are partnering to develop new ways to study the microbiome and develop new diagnostic approaches for disease-causing pathogens.
The spleen’s mechanisms for responding to blood-borne antigens mirror those in immune responses in other sites of the body, and could potentially be harnessed to prevent life-threatening immune responses in patients requiring frequent blood transfusions.
Experts say the success of precision medicine — developing therapies based on an individual patient’s unique genetic profile and lifestyle — will depend on continued research into basic biology and disease mechanisms using animal models.
New JAX resource will accelerate the creation, distribution and use of high-priority mouse models for Charcot-Marie-Tooth research.
Next Gen Ph.D.: A Guide to Career Paths in Science, a new book by Melanie V. Sinche, director of education at The Jackson Laboratory (JAX) for Genomic Medicine, provides tips and strategies for finding rewarding jobs in the sciences.
The Jackson Laboratory has named medical oncologist Jens Rueter, M.D., to the newly created position of medical director for the Maine Cancer Genomics initiative.
Martin F. Pera, Ph.D., is a leading stem cell researcher with interests in neuroscience and regenerative medicine. He will join The Jackson Laboratory in January 2017.
The discovery offers a potential therapeutic target for certain inflammatory disorders, such as asthma, Churg-Strauss syndrome and hypereosinophilic syndrome, that are characterized by abnormal myeloid cell lifespan.
The NIH has made a five-year grant totaling $11,714,623 to The Jackson Laboratory (JAX) to create a new Center for Systems Neurogenetics of Addiction headed by Associate Professor Elissa Chesler.
The National Institutes of Health (NIH) will award a total of $28,305,235 to The Jackson Laboratory (JAX) over five years to fund phase 2 of the Knockout Mouse Production and Phenotyping Project (KOMP2).
The Jackson Laboratory celebrated the groundbreaking for its new, state-of-the-art vivarium, a facility to maintain research mouse models, at the institution’s Ellsworth, Maine, location.
Sheng Li, Ph.D., a scientist who develops computational tools and studies cancer epigenomics, has been appointed an assistant professor at The Jackson Laboratory.
Harvard Stem Cell Institute (HSCI) researchers, with collaborators at The Jackson Laboratory, have found evidence that bone marrow transplantation may one day be beneficial to a subset of patients suffering from amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder more commonly known as Lou Gehrig’s disease.
Jackson Laboratory (JAX) researchers have found a precise and reliable way — whole-genome profiling of open chromatin — to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome
The American Medical Association (AMA), in partnership with Scripps Translational Science Institute (Scripps) and The Jackson Laboratory (JAX), have announced a new online program aimed at educating physicians and other health care professionals on the benefits and limitations of genetic testing and when it is appropriate to incorporate it into their practices.
Verhaak will join JAX from the University of Texas MD Anderson Cancer Center in Houston, where he is an associate professor in the Department of Bioinformatics and Computational Biology and the Department of Genomic Medicine.
The Jackson Laboratory’s Gene Expression Database will receive a total of $10.5 million in support over the next five years from the Eunice Kennedy Shriver National Institute of Child Health & Human Development.
The National Institute of Allergy and Infectious Diseases has awarded a grant totaling $3.4 million over five years to Jackson Laboratory Professor and Director of Immunological Sciences Jacques Banchereau, Ph.D.
Aimee Monroy Smith, a government affairs professional with a background in legislative and grassroots advocacy for nonprofit organizations, is the new director of government relations for The Jackson Laboratory (JAX) for Genomic Medicine.
Center for Biometric Analysis will equip scientists with essential, cutting-edge tools for detecting and measuring extremely subtle signs of disease at the cellular level in specialized mice.
Dr. Robinson is a computational biologist who develops bioinformatics resources and algorithms for translational research and medical care.
The newly created initiative will establish the Petit Family Foundation Summer Student Fellowship, Student Teacher Fellow, Teaching the Genome Generation Teacher Fellowship and Teaching the Genome Generation Implementation Fund.
Mingyang Lu, Ph.D., is a computational systems biologist who studies the complex genetics of cancer. He will join the JAX faculty in August.
JAX Assistant Professor Vivek Kumar will use the five-year grant to pinpoint genetic variants that increase susceptibility to addiction.
Multiplexed mass spectrometry paired with genetically varied mouse population yields broad insights.
Beth Dumont, Ph.D., a researcher focused on the cellular mechanisms that govern DNA inheritance, has joined The Jackson Laboratory faculty as an assistant professor.
Guangwen “Gary” Ren, Ph.D., who studies cancer therapy resistance and metastatic relapse, will join The Jackson Laboratory faculty as an assistant professor in October.
A charitable contribution of $8,410,000 from the Harold Alfond® Foundation will support The Jackson Laboratory’s efforts to enhance cancer diagnostics and treatment in Maine.
Alex Fine is one of eight predoctoral students who are receiving their Ph.D. training in mammalian genetics and genomic medicine in partnership with degree-granting programs at the University of Connecticut Health Center, Tufts University, and The University of Maine.
William Skarnes, Ph.D., an expert in stem cell engineering who began his career studying mouse developmental genetics, has been appointed director of cellular engineering at JAX.
Eating walnuts may change gut bacteria in a way that suppresses colon cancer, researchers at UConn Health and The Jackson Laboratory report in the journal Cancer Prevention Research.
Derya Unutmaz, M.D., will receive five years of funding totaling $3,281,515 from the National Institute of Allergy and Infectious Diseases to find better ways to diagnose and treat myalgic encephalomyelitis and chronic fatigue syndrome (ME/CFS).
A research grant from the National Institutes of Health totaling $3,436,466 over four years will enable a Jackson Laboratory research group led by Senior Research Scientist Laura Reinholdt, Ph.D., to develop new data resources and mouse models to better understand Mendelian genetic disorders.
Female cancer patients may be able to retain their fertility during radiation and chemotherapy through treatments that target the DNA damage response in oocytes.
Paige Brown and Demetri Maxim, two Maine high school students who captured top honors at the Maine State Science Fair, are among the Grand Award winners at the Intel International Science and Engineering Fair (ISEF) in Phoenix, Ariz., the world’s largest science fair.
The Jackson Laboratory, a global leader in mammalian cancer genetics modeling and education and human genomics, demonstrated that the albumin-based therapeutic, Tanzeum, had a six-fold increase in half-life in humanized FcRn mice with mouse albumin knocked out compared to when mouse albumin is present.
A Science Education Partnership Award from the National Institutes of Health totaling $1,281,975 will support five years of funding for Teaching the Genome Generation™, The Jackson Laboratory’s innovative teacher professional development program designed to enhance genetics instruction in high school classrooms.
New understanding of how a class of lipids called sphingolipids are formed could shed light on mechanisms of epilepsy, dementia and other neurodegenerative diseases, paving the way to new treatment approaches, according to Jackson Laboratory (JAX) researchers and their collaborators.
Olga Anczuków, Ph.D., is a breast cancer researcher who investigates how changes in gene regulation contribute to cancer.
The Jackson Laboratory and Calico, a company focused on aging research and therapeutics, have announced a multi-year collaboration focused on applying mouse genetics to the study of aging.
S. Catherine (Katy) Longley of Brunswick, Maine, will join The Jackson Laboratory in August as vice president and chief financial officer.
The MGD provides free access to a wealth of genetic, genomic and biological data to the worldwide biomedical research community, and is a critical resource for advancing the emerging field of precision genomic medicine.
Middle school students from the science- and math-focused Talcott Mountain Academy of Avon, Conn., won a practice science bowl scrimmage at The Jackson Laboratory (JAX) on April 7, against JAX researchers and other staff with advanced degrees.
Karolina Palucka, M.D., Ph.D., professor and associate director of cancer immunology at The Jackson Laboratory (JAX), was among the honorees at the Connecticut Technology Council’s 12th Annual Women of Innovation Awards Gala in Plantsville, Conn., on April 6.
Research team led by JAX CEO Edison Liu has found the molecular fingerprint — and a potential therapy — for some of the deadliest cancers affecting women.
Bangor High School students take second, third places
Boosting synaptic efficacy may help alleviate symptoms for patients with a neurological condition called Charcot-Marie-Tooth type 2D (CMT2D).
Maine State Science Fair takes place Saturday, March 19 at the Cross Insurance Center in Bangor.
The international Human Genome Organisation has named as its new president Charles Lee, Ph.D., FACMG, professor and scientific director of The Jackson Laboratory for Genomic Medicine
Robert Braun, one of the nation's leading reproductive biologists, has been appointed to the endowment established by JAX Trustee Weslie Janeway.
The Jackson Laboratory (JAX) for Genomic Medicine has now reached 200 employees.
The Jackson Laboratory (JAX) has dramatically expanded access to the NSG™-SGM3 mouse model to scientists worldwide.
The Jackson Laboratory (JAX) raised a record amount of philanthropic support—over $11.5 million—for its mission in 2015, more than in any single year in its 86-year history.
Chia-Lin Wei, Ph.D., an international leader in genomics and sequencing, has joined The Jackson Laboratory (JAX) as director of genome technologies.
A new study published in The Journal of Immunology describes a novel regulatory link between miR-34a expression and apoptotic cell clearance from tissues, or efferocytosis, by resident macrophages. Further characterizing this mechanism may promote new treatment paradigms for individuals with diseases caused by defects in efferocytosis, such as some autoimmune disorders.
A new gene regulation and labeling platform dubbed "Casilio" is expanding researchers' ability to study gene function and chromosome structure.
Dennis J. Paustenbach, Ph.D., a pioneer in the health and environmental risk assessment industry, has made a $1 million planned gift to The Jackson Laboratory to support cancer and immunology research. The gift will establish an endowment called the Paustenbach Family Cancer and Immunology Research Fund.
Jackson Laboratory (JAX) cancer researcher Carol Bult, Ph.D., has been appointed to the Knowlton Family Chair, an endowed professorship newly established by Winthrop Knowlton, chairman emeritus of the Laboratory’s board of trustees.
A butterfly-shaped pigment accumulation in the macula of the eye, which can lead to severe vision loss in some patients, is due to mutations in the alpha-catenin 1 gene (CTNNA1), an international research consortium including a team from The Jackson Laboratory reports in Nature Genetics.
A $500,000 gift from the Libra Foundation of Portland, Maine, to The Jackson Laboratory (JAX) will support technological and therapeutic innovations with exceptional potential to improve health care and biomedical science.
Protein factors are responsible for organizing chromosomes inside the nucleus in three dimensions (3D), forming a shape like a gift bow, with proteins aggregating as the central “knot” holding the ribbon-like loops of DNA when genes are organized for proper expression, or a tangled mess in the presence of certain mutations.
The Australian Academy of Health and Medical Sciences (AAHMS) has named Nadia Rosenthal, Ph.D., F.Med.Sci., professor and scientific director of The Jackson Laboratory’s headquarters mammalian genetics campus, as a 2015 Fellow.
Reinhard C. Laubenbacher, Ph.D. of UConn Health and The Jackson Laboratory (JAX) for Genomic Medicine has been named a Fellow of the American Association for the Advancement of Science (AAAS).
J. Travis Hinson, M.D., a board-certified cardiologist and researcher interested in bringing an interdisciplinary approach to the study of heart muscle diseases, will join the faculties of The Jackson Laboratory for Genomic Medicine and UConn Health.
Nadia Rosenthal, Ph.D., F.Med.Sci., professor and scientific director of mammalian genetics at The Jackson Laboratory, is the editor in chief of npj Regenerative Medicine, a new addition to the prestigious Nature journal group.
Cyteir is leveraging its expertise in DNA repair and genome instability to develop new targeted therapeutics for cancer, autoimmune disorders and more.
JAX researchers say structural deterioration associated with old age can be prevented by long-term aerobic exercise starting in mid-life.
In work involving several new generations of mouse model development, Jackson Laboratory (JAX) researchers have tested a therapeutic intervention for spinal muscular atrophy (SMA) that restores some function lost due to a mutation in one gene (SMN1) and amplifies the levels of protective genes (SMN2). Moreover, unlike current interventions, the therapy appears to work after symptoms of SMA have already appeared, and may not need to be administered directly into the central nervous system.
A $3.7 million grant has been awarded to Professor Yijun Ruan, Ph.D., to fund research into how the human genome is organized in the nucleus of the cell.
As part of a comprehensive relationship to advance cancer research and accelerate personalized genomic medicine, The Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) and The Jackson Laboratory (JAX) have launched seven joint research projects to study a variety of cancer types, including multiple myeloma, lung, breast, prostate and brain cancers. The projects bring together 28 scientists – 14 from each institution – to lead investigations ranging from basic science to the development of clinical therapies.
A mutation that increases the level of a special class of sphingolipids—molecules important to cell structure and signaling—can lead to neurodegeneration due to problems with neuronal membranes, reports a research team led by Jackson Laboratory Research Scientist Lihong Zhao, Ph.D. and Professor Patsy Nishina, Ph.D.
A consortium of international researchers, including Charles Lee, Ph.D., professor and scientific director at The Jackson Laboratory for Genomic Medicine and a distinguished professor of Ewha Womans University have reported findings from a massive research project exploring variations in the human genome, including structural variations.
The National Institute on Aging (NIA) has announced a grant of $3,567,446 to Jackson Laboratory (JAX) Assistant Professor Gareth Howell, Ph.D., and Harvard University Assistant Professor Beth Stevens, Ph.D., for research in mechanisms of Alzheimer’s disease
A Jackson Laboratory-led research team has identified two druggable targets for gastric cancer through a genomic molecular profiling technique, and validated the findings in mouse models capable of hosting human tumors.
Six senior officials and scientists from The Jackson Laboratory (JAX) will visit Ewha Womans University in Seoul for an International Joint Symposium on Genomic Medicine on Oct. 2.