Studies the role of progenitor cells in cardiovascular remodeling. Develops tools for research in Protein Science.
Our lab uses multi-omics systems biology approaches to study blood pressure regulation, cardiovascular genomics and epigenomics, as well as membrane and cellular proteins and their role in cell signaling and cell-cell interaction. Our work has helped to characterize the renin-angiotensin system at the cellular, molecular, and whole animal levels and has helped to define the role of the renin-angiotensin-aldosterone system in angiogenesis. We created and characterized the first renin knockout rat, and explored the molecular regulation of renin in salt-sensitive hypertension. We were also among the first to recognize the importance of bone marrow derived mononuclear and endothelial progenitor cells in angiogenesis and have published several key papers describing the importance of gene-environment interaction in the competency of these cells. Our laboratory is also interested in developing techniques for the study of genes and proteins and their interactions in physiological systems.