Postdoctoral Faculty

Name Last Name Location Research Summary 2nd Research Area Research Area Lab Affiliation Job Title

Elaheh Ahmadzadeh, Ph.D.

Postdoctoral Associate

Farmington, CT

860-837-2474

    Ahmadzadeh Elaheh Ahmadzadeh, Ph.D. Farmington, CT
    Focuses on understanding the interplay between various immune effector cells and tumor metastasis in breast cancer.
    Read less Read more…

    Focuses on understanding the interplay between various immune effector cells and tumor metastasis in breast cancer.

    The Palucka Lab Postdoctoral Associate
    Akturk Anil Akturk, Ph.D. Bar Harbor, ME
    Profile page of Anil Akturk Ph.D.
    The Tarchini Lab Postdoctoral Associate
    Albright Brandon Albright, Ph.D. Farmington, CT
    My goal is to use viral metagenomics to understand the complex interactions between viruses and their hosts.
    Read less Read more…

    Beginning with my undergraduate research, working on bacteriophages (bacterial viruses), I have been fascinated in the diversity and complexity of viruses. This interest led me to pursue a Ph.D. studying how Herpes Simplex Virus manipulates the intra-cellular environment to establish infection. Upon receiving my Ph.D., I served as a Postdoc at Yale University studying another human virus, JC Polyomavirus, with the goal of understanding the cellular factors that facilitated viral entry. Now at the Jackson Laboratory, I mine through large scale genomic datasets to understand the range of viruses that exist in different populations. The goal of my current work is to develop ways to examine these complex virus-host relationships and to help the field get a better understanding as to how viruses contribute to health and disease.

    Download CV

    Computational Biology|Genetics and Genomics|Infectious Disease Research Computational Biology|Genetics and Genomics|Infectious Disease Research The Weinstock Lab Postdoctoral Associate
    Amin Samir B Amin, MBBS, Ph.D. Farmington, CT
    Working in the comparative oncology field to study spontaneous development of glioma in Canis familiaris or dogs with emphasis on characterizing and comparing cancer genome and transcriptome to that in human glioma.
    Read less Read more…

    Dr. Amin received his Ph.D. in cancer computational biology from Baylor College of Medicine, Houston, TX in 01/2017. His thesis work was carried out at the UT MD Anderson Cancer Center, and was focused on understanding long non-coding RNA interactions in the context of chromatin organization using integrated analyses of publically available expression, epigenomic and chromatin interaction data. Before completing Ph.D., Dr. Amin received research training (2008-2011) in computational biology at the Dana-Farber Cancer Institute, Boston, MA where he worked on the assessment of gene expression profiling as predictive biomarker in multiple myeloma. Previously, Dr. Amin received his first professional degree in medicine, MBBS from the Medical College of Maharaja Sayajirao University of Baroda, Vadodara, India in 2005.

    Download CV

    Bioinformatics|Computational Biology|Genetics and Genomics|Cancer Bioinformatics|Computational Biology|Genetics and Genomics|Cancer The Verhaak Lab Postdoctoral Associate
    Anderson Kevin J. Anderson, Ph.D. Farmington, CT
    Integrates biomechanical and genomic approaches towards the analysis of brain tumor heterogeneity and disease evolution.
    Read less Read more…

    Dr. Anderson received his Ph.D. in Biomedical Engineering from Cornell University. For his thesis research he adapted a multiscale numerical simulation towards the analysis of the initial behavior of circulating tumor cell aggregates interacting with activated endothelium. Previously, he received his B.S. in Biomedical Engineering at the University of Alabama at Birmingham.

    Download CV

    Bioinformatics|Cancer|Computational Biology|Genetics and Genomics Bioinformatics|Cancer|Computational Biology|Genetics and Genomics The Verhaak Lab Postdoctoral Associate

    Selcan Aydin, Ph.D.

    Postdoctoral Associate

    Bar Harbor, ME

    207-288-6000

      Aydin Selcan Aydin, Ph.D. Bar Harbor, ME
      Postdoctoral Associate working for Steven Munger.
      Read less Read more…

      Postdoctoral Associate working for Steven Munger.

      The Munger Lab Postdoctoral Associate
      Barthel Floris Barthel, M.D. Farmington, CT
      Deploys next-generation sequencing techniques to understand brain tumor biology and telomere mechanics
      Read less Read more…

      Dr. Barthel received his M.D. degree from the Vrije Universiteit Amsterdam prior to joining the MD Anderson Cancer Center in Houston to pursue a postdoctoral position in glioma genomics. He research is focused on transcriptional and epigenetic profiling of gliomas and in understanding the genomic basis of telomere maintenance in cancer.

      Computational Biology|Bioinformatics|Cancer|Genetics and Genomics Computational Biology|Bioinformatics|Cancer|Genetics and Genomics The Verhaak Lab Postdoctoral Associate
      Benjamino Jacquelynn Benjamino, Ph.D. Farmington, CT
      Utilizes various sequencing technologies and analysis tools to study the microbiome of health and disease.
      Read less Read more…

      Jacquelynn received her Ph.D. from the University of Connecticut where she studied eukaryotic and prokaryotic microorganisms in complex gut microbiomes using 16S, metagenomic, and metatranscriptomic sequencing technologies. She is interested in understanding the functional roles of microbes in health and disease.

      Download CV

      Bioinformatics|Computational Biology|Genetics and Genomics|Infectious Disease Research Bioinformatics|Computational Biology|Genetics and Genomics|Infectious Disease Research The Adams Lab Postdoctoral Associate
      Bhattacharyya Tanmoy Bhattacharyya, Ph.D. Bar Harbor, ME The Handel Lab Postdoctoral Associate
      Chen Yang Chen, Ph.D. Farmington, CT
      Single cell Transcriptomics, 3D Genomics
      Read less Read more…

      Postdoctoral associate: 2017-current

      Visit the Personal Ouyang  Lab Site

      Bioinformatics|Computational Biology Bioinformatics|Computational Biology The Ouyang Lab Postdoctoral Associate
      Cortes-Perez Daniel Cortes-Perez, M.D., Ph.D. Bar Harbor, ME
      Stem cell biology and neural differentiation to study neurological diseases and aging using genetic approaches. Axonal repair, neurotrophic factors and DYRK1a are also of interest
      Read less Read more…

      After doing my Ms. Sc. studying ischemia and reperfusion in the liver and how adenosine receptors can modulate metabolic pathways during this insult; I decided to move toward stem cell and neuroscience field during my Ph. D. training. I was interested in the transgenic expression of Glial-cell line derived neurotrophic factor (GDNF) in stem cells and neuronal derivatives. GDNF-secreting embryonic stem cell differentiation to motor neurons goes through a phase of increased number of cycling motor neuron precursors, enhancing terminal differentiated motor neuron yield and electrical maturation, even without any other trophic or cellular support. My ongoing work at JAX tries to unveil the genetic basis of individual differences in the response of the central nervous system to injury using pluripotent stem cells and transgenic mice as models.

      Download CV

      Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases The Pera Lab Postdoctoral Associate
      de Groot Theun de Groot, Ph.D. Bar Harbor, ME
      Researches lithium-induced kidney damage and genetic susceptibility.
      Read less Read more…

      Lithium is widely prescribed and the mainstay treatment for bipolar disorders. Unfortunately, lithium treatment leads to nephrogenic diabetes insipidus (NDI), hypercalcaemia and chronic kidney disease (CKD) in approximately 15, 20 and 40 percent of patients respectively. Lithium- induced NDI is caused by the inability of the renal collecting duct to reabsorb water. Hypercalcaemia is likely due to a decreased sensitivity of the parathyroid gland to blood Ca2+ levels. The molecular cause of lithium-induced CKD is largely unknown. Previous studies demonstrated that lithium treatment of different rodent models also leads to the development of these side effects. The aim of my study is to identify novel genes that play an essential role in the pathogenesis of these side effects. For this purpose 29 genetically diverse mouse strains are treated with a control or lithium diet, and subsequently we assess the development of these side effects in each strain. We have already observed that some strains are much more sensitive to developing a side effect as compared to other strains. By associating the sensitivity of the strains to developing these side effects with their genetic variations, we aim to identify novel genes and pathways essential in their development.

      Download cv

      Genetics and Genomics Genetics and Genomics Postdoctoral Associate
      Dickson Price Dickson, Ph.D. Bar Harbor, ME
      Integrates operant and classical conditioning paradigms with modern systems genetics techniques to identify the genetic and genomic mechanisms underlying the behavioral processes of drug addiction and related behavioral disorders.
      Read less Read more…

      I integrate operant and classical conditioning paradigms with modern systems genetics techniques to identify the genetic and genomic mechanisms underlying fundamental behavioral processes driving drug addiction and related behavioral disorders.

      Download cv

      Genetics and Genomics|Computational Biology|Complex Traits|Bioinformatics Genetics and Genomics|Computational Biology|Complex Traits|Bioinformatics The Chesler Lab Postdoctoral Associate
      Dunn Amy Dunn, Ph.D. Bar Harbor, ME
      I am interested in understanding how genetic context mediates effects of environmental risk factors in neurodegenerative diseases like Alzheimer's disease.
      Read less Read more…

      I graduated from Emory University with a PhD in neuroscience in May of 2017, and shortly thereafter joined the Kaczorowski lab as a postdoctoral associate. I am employing a genetically diverse mouse model of Alzheimer's disease to investigate how genetic variability mediates the effects of a high fat diet on Alzheimer's-associated pathogenesis. In general, high fat diets increase risk and rate of decline in Alzheimer's disease, though in humans and in our mouse model, this is dependent on an individual's genetic context. I use a variety of behavioral, molecular, and computational techniques which will precisely identify which gene candidates and molecular networks are responsible for regulating this variability. Ultimately, these studies should lead to novel therapeutic targets for more personalized treatment strategies for Alzheimer's disease.

      Download CV

      Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases The Kaczorowski Lab Postdoctoral Associate
      Dwyer Jennifer Dwyer, Ph.D. Bar Harbor, ME
      Elucidating the molecular mechanisms that underlie autoimmunity in Type 1 diabetes
      Read less Read more…
      Type 1 diabetes is the autoimmune-mediated destruction of insulin-producing pancreatic Beta-cells that leads to lifelong insulin therapy.  Using the non-obese diabetic (NOD) mouse model which succumbs to type 1 diabetes at a young age, the Serreze lab has identified Nuclear Factor kappa B inhibitor Delta (Nfkbid) as a modulator of disease incidence. Nfkbid-deficient mice demonstrate an accelerated disease onset, despite improved thymic negative selection of autoreactive T cells that is associated with decreases in regulatory T cell populations.  My research is focused on understanding molecular mechanisms by which Nfkbid influences regulatory T cell populations in an effort to ultimately develop therapies to halt the autoimmune destruction seen in Type 1 diabetes.
       

       

      Diabetes and Obesity|Immune Disorders Diabetes and Obesity|Immune Disorders The Serreze Lab Postdoctoral Associate
      Emiola Akintunde Emiola, Ph.D. Farmington, CT
      Akintunde plans to develop single cell sequencing technology to define "dark matter" microorganisms, and search for bacteria that encode genes for antibiotic resistance or other immune-related function.
      Read less Read more…
      Akintunde Emiola earned his Master’s and Ph.D. at the University of East London in the United Kingdom. During his doctoral work in systems biology, Akintunde developed and tested algorithms that modeled the step-wise synthesis of Lipid A, a crucial part of the outer membrane in E. coli bacteria. In the Oh lab, Akintunde is interested primarily in the therapeutic potential of the “dark matter,” the unidentified and uncharacterized bacteria living on the human skin. He plans to develop single cell sequencing technology to define these microorganisms, and search for bacteria that encode genes for antibiotic resistance or other immune-related function.
      Genetics and Genomics|Infectious Disease Research Genetics and Genomics|Infectious Disease Research The Oh Lab Postdoctoral Associate
      Emori Chihiro Emori, Ph.D. Bar Harbor, ME Cancer|Reproductive Disorders Cancer|Reproductive Disorders The Bolcun-Filas Lab Postdoctoral Associate
      Graham Kourtney Graham, Ph.D. Bar Harbor, ME
      Integrates in vivo Ca2+ imaging and chemogenetic techniques to investigate neural circuits involved in the regulation of food intake
      Read less Read more…

      I graduated from Florida State University with a PhD in Neuroscience in May of 2017 and joined the O’Connell lab shortly thereafter as postdoctoral associate. I am studying the neural circuits involved in the control of food intake in the context of obesity. In general, obesity occurs when homeostatic mechanisms that regulate food intake and energy expenditure become dysregulated due to excessive caloric intake and decreased activity. Glial cells are critical to the development, function and maintenance of neuronal circuits involved in food intake. In particular, astrocytes – the most abundantly expressed glial cells in the brain – are well-established in their role of providing crucial metabolic support to neurons. I am interested in delineating the mechanisms by which diet-induced obesity modulates astrocyte-dependent changes in neuronal activity and feeding behavior. To do this, I use in vivo Ca2+ imaging and chemogenetic techniques to simultaneously modulate and measure neuronal and astrocyte activity while the mice are performing food-seeking behaviors. Ultimately, these studies should provide crucial insights into the progression of obesity as well as changes that may occur in astrocyte activity in response to high-fat diet.

      Behavioral Disorders|Diabetes and Obesity Behavioral Disorders|Diabetes and Obesity The O'Connell Lab Postdoctoral Associate
      Harder Jeffrey Harder, Ph.D. Bar Harbor, ME
      Researching axon degeneration and the roles of immunity in the central nervous system and diet in glaucoma.
      Read less Read more…

      I joined the Simon John lab in the spring of 2013, excited by the opportunity of working with Dr. John and using a multidisciplinary approach in my research. Using DBA/2J mice as a model of glaucoma, my current research focuses on axon degeneration, the role of innate immunity in the central nervous system, and the role of diet in neurodegeneration. This includes studying the role of JNKs in glaucomatous injury and working to identify early signaling events that may initiate injury. For another project, I am collaborating with faculty from Dalhousie University, working on defining human genes responsible for exfoliation syndrome glaucoma. I also work closely with fellow postdoc Pete Williams and help direct two research assistants in the lab.  This opportunity to collaborate and manage while working through complex projects is broadening my conceptual thinking abilities both scientifically and managerially, and improving the array of skill sets necessary for running a lab.

      Download cv


      Genetics and Genomics|Complex Traits|Bioinformatics Genetics and Genomics|Complex Traits|Bioinformatics The John Lab Postdoctoral Associate
      Hicks Amy N. Hicks, Ph.D. Bar Harbor, ME
      Utilizes spontaneous and CRISPR/Cas9 generated mouse lines along with primary cell culture models to look at the molecular intersection between the motor neuron and heart phenotypes in mouse models of Spinal Muscular Atrophy with Respiratory Distress (SMARD).
      Read less Read more…

      Spinal Muscular Atrophy with Respiratory Distress (SMARD) is a very rare recessive form of Spinal Muscular Atrophy (SMA) that typically presents as acute respiratory failure between 6 weeks to 6 months of age followed by a progressive motor paralysis. Most patients die within 2-3 years, but some do plateau and live for many years with continuous respiratory, feeding and mobility support. Unfortunately, there is currently no cure.

      A variety of different mutations in the Immunoglobulin mu-binding protein 2 (Ighmbp2) gene have been identified to be the cause of SMARD, but the mechanism of how these mutations result in this disease are still unknown. Since this is a recessive disease, that means that two mutant copies of the gene are required to be inherited…one from each parent.

      In 1998, Greg Cox identified the first mouse model of this disease called nmd2J which is still the only model of SMARD utilized for research. The phenotype of these mice is consistent with the human patients. Unexpectedly, a genetic rescue of the nerves in this mouse model rescued the paralysis, but it also resulted in the development of a dilated cardiomyopathy (Maddatu TG et al. Hum Mol Genet 2004).

      My work focuses on the molecular mechanism underlying both the motor neuron and cardiomyocyte phenotypes that develop as a result of mutations in Ighmbp2. Even though heart issues have not been identified in SMARD1 patients, the fear is that any treatment that fixes the paralysis and does not also treat the heart may produce the same fate for patients that we see in the mouse. The ultimate goal of this work is to identify therapeutic targets in both the heart and spinal cord….hopefully in both….to provide treatments to delay/stop cell death and expand the therapeutic window for genetic interventions.

      Wild Type Image Diagram

      Wild-type is the C57BL/6J inbred mouse strain, nmd2J is a homozygous mutant, and the rescued nmd2J is a homozygous mutant carrying a neuron-specific transgene of the Ighmbp2 gene to specifically rescue the paralysis. Femoral motor neuron cross-sections were imaged from 1 month old animals at 40x magnification. Whole heart longitudinal sections from 7-week-old animals were stained with Masson’s trichrome and imaged at 20x magnification. (Note: The rescued nmd2J nerve looks like the wild-type nerve).

       

      Download CV

      Genetics and Genomics|Aging|Neurodegenerative and Neuromuscular Diseases Genetics and Genomics|Aging|Neurodegenerative and Neuromuscular Diseases The Cox Lab Postdoctoral Associate
      Hines Timothy Hines, Ph.D. Bar Harbor, ME
      Using molecular, histological, and physiological techniques to study mouse models of Charcot-Marie-Tooth (CMT) disease.
      Read less Read more…

      I obtained my Ph.D. in Biological Sciences from the University of South Carolina in August 2018. Here, I worked under Dr. Deanna Smith studying the regulation of microtubule motor-mediated axonal transport and how disruption of this process is linked to neurodegeneration. Following my dissertation defense, I took a postdoctoral position at The Jackson Laboratory with Dr. Rob Burgess due to our overlapping interests in neurodegenerative diseases and axon biology.

      The Burgess lab is focused on generating and studying mouse models of inherited peripheral neuropathies, including Charcot-Marie-Tooth (CMT) disease. My research focuses on understanding how mutations in some ubiquitously expressed genes, such as tRNA synthetases, can cause a disease affecting specific tissues or cell populations. Additionally, I would like to understand the role of genetic modifiers in the phenotypes observed in our mouse models. Identifying the mechanisms underlying these genetically distinct diseases will enable us to target disease-specific processes in an attempt to alleviate symptoms caused by these genetic mutations.

      Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases The Burgess Lab Postdoctoral Associate

      Li Hua

      Postdoctoral Associate

      Bar Harbor, ME

      Hua Li Hua, Ph.D. Bar Harbor, ME
      Stromal cells may provide a positive or negative role in modulating the immunotherapy.
      Read less Read more…

      Allogeneic tumors are eventually rejected by adaptive immune responses, however, little is known about how allogeneic tumors are eradicated at the early stage of tumor development. In the study, we found that NKG2DL low expressing cancer cells were developed into palpable allogeneic tumors in mice within a week after the inoculation, while NKG2DL high expressing cancer cells failed to. Artificially up-regulating NKG2DL on cancer cells with low level expressed NKG2DL by a CpG ODN resulted in the retardation and rejection of the allogeneic tumors at the early stage. The contribution of up-regulated NKG2DL to the early rejection was further confirmed by the results that the development of allogeneic tumors from cancer cells transfected with NKG2DL genes was significantly inhibited in mice at the early stage.

      Download CV

      Cancer Cancer The Ren Lab Postdoctoral Associate
      Johnson Jethro Johnson, Ph. D. Farmington, CT
      Studying host-microbiome interactions at a functional genomic level.
      Read less Read more…

      Dr. Johnson has a PhD in nutritional ecology and completed a career development fellowship in computational genomics before joining the Weinstock Lab. His interest is in leveraging next-generation sequencing technologies to study how environmental factors, such as nutrition, influence host-microbiome interactions at a functional genomic level.

      Computational Biology|Genetics and Genomics|Diabetes and Obesity Computational Biology|Genetics and Genomics|Diabetes and Obesity The Weinstock Lab Postdoctoral Associate
      Johnson Kevin C. Johnson, Ph.D. Farmington, CT
      Leverages genomic technologies to investigate brain tumor biology and disease evolution.
      Read less Read more…

      Dr. Johnson has a Ph.D. in Experimental and Molecular Medicine from Dartmouth where he received comprehensive training in quantitative and basic biomedical sciences. He has strong interest in the dynamic epigenomic landscape of glioma cells during disease progression and recurrence.

      DOWNLOAD CV

       

      Bioinformatics|Cancer|Genetics and Genomics|Computational Biology Bioinformatics|Cancer|Genetics and Genomics|Computational Biology The Verhaak Lab Postdoctoral Associate
      Katebi Ataur Katebi, Ph.D. Bar Harbor, ME
      Studies the architectures, dynamics, and functions of proteins as biological nano-machines and their interactions in biological networks.
      Read less Read more…

      Protein-protein interactions in biological networks.

      Computational Biology Computational Biology The Lu Lab Postdoctoral Associate
      Keele Greg Keele, Ph.D. Bar Harbor, ME
      Statistical modeling of proteomic data to better understand protein dynamics as well as provide a more complete picture of the regulation of complex phenotypes.
      Read less Read more…
      Dr. Keele completed his doctoral studies in bioinformatics and computational biology at the University of North Carolina at Chapel Hill, developing statistical methods for the design and analysis of experiments of multiparental populations, such as the Collaborative Cross (CC) and the Diversity Outbred (DO) stock in mice. Recently he joined the lab of Dr. Gary Churchill, where he is focused on statistical approaches to model and analyze mass spectrometry shot gun proteomics data. Relatedly, he is interested in the genetic regulation of complex phenotypes, particularly through integrative analysis of multiple levels of data per subject, such as genotype, gene expression, and protein abundance. 
      Complex Traits|Genetics and Genomics|JAX Genetic Diversity Initiative Complex Traits|Genetics and Genomics|JAX Genetic Diversity Initiative The Churchill Lab Postdoctoral Associate
      Kent Travis Kent, Ph.D. Bar Harbor, ME
      Studies the role of the somatic environment on meiosis by utilizing a novel method of simplifying the testicular architecture.
      Read less Read more…

      I joined the laboratory of Dr. Mary Ann Handel in the fall of 2015. The Handel laboratory focuses on the genetics of meiosis and how errors in meiosis can lead to developmental abnormalities. My work focuses on understanding the manner in which germ cells properly exit meiotic prophase. Specifically, I am interested in the role the somatic environment plays in the process. I utilize a novel method of synchronizing spermatogenesis in both wild type and transgenic mouse models to better anchor events occurring in germ cells in their proper somatic context. Outside of the laboratory, I am interested in the intersection between science and policy. I help lead a journal club for the JAX Summer Student Program highlighting science in the media spotlight. I also have been an active participant in the Rally for Medical Research, lobbying Congressmen and women to commit to increased funding for the National Institute of Health. This combined experience has provided me with the skills to be both a discerning scientist and an effective ambassador for the scientific community.

      Genetics and Genomics|Reproductive Disorders Genetics and Genomics|Reproductive Disorders The Handel Lab Postdoctoral Associate
      Khetan Shubham Khetan Farmington, CT
      Interested in understanding how Type 2 Diabetes associated GWAS SNPs confer risk
      Read less Read more…

      I completed my undergraduate studies in Biotechnology at IIT Roorkee, India. This was followed by a project in the Axon Regeneration Lab at IISc Bangalore, under Dr. Ramanan's supervision. I am currently a Graduate Assistant in the Stitzel and Ucar lab at JAX-GM.

      Bioinformatics|Complex Traits|Diabetes and Obesity|Genetics and Genomics Bioinformatics|Complex Traits|Diabetes and Obesity|Genetics and Genomics The Stitzel Lab|The Ucar Lab Postdoctoral Associate
      Kim Ji Hun Kim, Ph.D. Farmington, CT
      Manipulates genome structures using CRISPR-Cas9 and characterize their functional effect on  disease development.
      Read less Read more…

      During my Ph.D, I investigated the structures of the chromosomes and chromatins and the functional roles of the chromosome scaffold proteins. From this study, I suggested how chromatin is compacted and form the known "sausage" shaped structures of the mitotic chromosomes as well as their novel function in transcription.

      In the Lee lab, I am interested in the functional effect of copy number alterations in human diseases. For this study, I manipulate the genome structures using the cutting-edge genome-editing technology called CRISPR-Cas9 and characterize their functional effect on the disease development in both in vitro and in vivo models, and eventually investigate the potential cure of it.

      Download CV

      Bioinformatics|Computational Biology|Genetics and Genomics Bioinformatics|Computational Biology|Genetics and Genomics Postdoctoral Associate
      Kim Minji Kim, Ph.D.
      Computational Biology, 3D Genome Organization
      Read less Read more…

      Analyze ChIA-PET (Chromatin Interaction Analysis by Paired-End Tag Sequencing) to uncover genome organization.

      Data Science at JAX|Computational Biology Data Science at JAX|Computational Biology The Ruan Lab Postdoctoral Associate

      Austin Korgan

      Postdoctoral Associate

      Bar Harbor, ME

      207-288-1725

        Korgan Austin Korgan, Ph.D. Bar Harbor, ME
        My research focuses on understanding the impact of diet induced obesity on neuronal plasticity in brain regions associated with the regulation of food intake.
        Read less Read more…

        I graduated from Dalhousie University with a Ph.D. in neuroscience in August of 2017, and shortly thereafter joined the O’Connell lab as a postdoctoral associate. I am interested in studying 'top-down' mechanisms regulating the development and maintenance of diet induced obesity (DIO). Appetitive circuits in the central nervous system are changed by nutritional experience and DIO. Thus, treatment strategies that aim to control appetite and decrease body weight must target these circuits. The O’Connell lab focuses on AgRP neurons in the hypothalamus and the impact that DIO has on their excitability, plasticity, and regulation of gene expression. By pairing advanced electrophysiological techniques, coupled with 'omics’, computational analyses, biochemical, and behavioral techniques we are able to probe the hypothalamus and further characterize the neuronal populations responsible for regulating appetite. Ultimately, we aim to identify novel therapeutic targets underlying development and maintenance of diet-induced obesity.

        The O'Connell Lab Postdoctoral Associate

        Huawen Li, Ph.D.

        Postdoctoral Associate

        Bar Harbor, ME

          Li Huawen Li, Ph.D. Bar Harbor, ME
          Conducts research seeking targets for new pharmaceutical approaches based on protein stress.
          Read less Read more…

          The stress response is an evolutionarily, highly conserved adaptive mechanism that enhances cell survival. Genome instability is a hallmark of cancer cells. We are highly interested in the relationship between these two factors. We use mouse models to mimic lung cancer, which have obvious genome instability. We also use molecular methods to find the basis for how these pathways talk to each other. This work might give us some clue or target for new pharmaceutical approaches based on protein stress.

          Download cv

          Cancer Cancer Postdoctoral Associate
          Li Peishan Li, Ph.D. Bar Harbor, ME
          The Roles of MSC and Adipocytes in Cancer Metastasis
          Read less Read more…

          We have realized that the resistance of many breast cancer patients against various therapies is mainly caused by tumor environment in our own body. Therefore, how to therapeutically target the tumor environment becomes a key question for current breast cancer therapy. Our research goal is to develop more novel strategies targeting tumor environment cells to improve the efficacy of current cancer therapeutics, and ultimately prolong the lives of cancer patients.

          Download CV

          Cancer Cancer The Ren Lab Postdoctoral Associate
          Liu Jihe Liu, Ph.D. Farmington, CT
          Apply genetic and genomic approaches to understand brain cancer and tumor evolution.
          Read less Read more…

          Dr. Liu received his Ph.D. in chemical biology from University of Pittsburgh, Pennsylvania, in 2017. Prior to that, he received his B.S. in bioinformatics from Huazhong University of Science and Technology, China, in 2011. His current research interest is to apply genetic and genomics techniques to study mechanisms of brain tumor evolution.

          Download CV

          Bioinformatics|Cancer|Computational Biology|Genetics and Genomics Bioinformatics|Cancer|Computational Biology|Genetics and Genomics The Verhaak Lab Postdoctoral Associate

          Lucas Lochovsky

          Postdoctoral Associate

          Farmington, CT

          860-837-2155

            Lochovsky Lucas Lochovsky Farmington, CT
            Interested in developing bioinformatics software for studying structural variation in cancer
            The Lee Lab Postdoctoral Associate

            Arojit Mitra, Ph.D.

            Postdoctoral Associate

            Bar Harbor, ME

            207-288-6000

              Mitra Arojit Mitra, Ph.D. Bar Harbor, ME
              Postdoctoral Associate working for Vivek Kumar.
              Read less Read more…

              Postdoctoral Associate working for Vivek Kumar.

              The Kumar Lab Postdoctoral Associate
              Mouri Kousuke Mouri, Ph.D. Bar Harbor, ME
              I'm interested in non-coding regulatory sequence which relates to human disease and diversity.
              Read less Read more…

              After getting Ph.D with Drosophila studies, I moved to National Institute of Genetics in Japan and started to study mouse genetics. In my post-doc study, I got interested in non-coding regulatory sequences.

              In JAX, I want to decipher the mechanisms how the change of regulatory sequences cause human disease.

              Genetics and Genomics|Immune Disorders Genetics and Genomics|Immune Disorders Postdoctoral Associate
              Natarajan Sivaraman Natarajan, Ph.D. Bar Harbor, ME
              Conducts research focused on determining the role of the Hippo signaling pathway and Notch1 during cortex and cerebellar development.
              Read less Read more…

              I am interested in studying the signaling pathway and its regulation in brain tumors. As a postdoctoral associate in the Kyuson lab, my research focused on understanding the molecular mechanisms, signaling pathways and role of cancer stem cells in brain cancers such as medulloblastoma and glioblastoma. Currently my research is focused on determining the role of the Hippo pathway and Notch1 during cortex and cerebellar development. Activation of the Notch pathway has been observed in many human cancers, but the role of Notch1 was unknown. Interestingly, we found that Notch1 induces medulloblastoma in a p53-dependent manner. We discovered the oncogenic role of Notch1 in a mouse model of medulloblastoma. Our lab recently showed that Notch1 directly activates a transcriptional effector of the Hippo pathway, namely Yap1, in neural stem cells in vivo (Li et al., 2012), linking the two important signaling pathways in stem cells in the brain. Yap1 functions as a major downstream effector of the Hippo pathway. The Yap gene locus is known to be amplified in human cancers, including oral squamous cell carcinomas and medulloblastoma. Using various mouse models of medulloblastoma and conditional knockout, I am trying to decipher the function of Yap1 in brain development and medulloblastomas.

              Developmental Disorders|Neurodegenerative and Neuromuscular Diseases|Cancer Developmental Disorders|Neurodegenerative and Neuromuscular Diseases|Cancer Postdoctoral Associate
              Nath Pulak Nath, Ph.D. Farmington, CT
              Aging is inevitable. I am interested in deciphering molecular mechanisms of immune aging to better shape the quality of life of the elderly.
              Read less Read more…

              I have received my Ph.D. training in Prof. N. Isakov’s T cell signaling laboratory in the Ben-Gurion University, Israel. I always have wondered how variable would a T cell be in responding to the similar antigenic stimuli during the course of a human lifetime. Recent studies show that alterations in the epigenome as well as isoform switch significantly contribute towards erosion of CD8 T cell’s activation responses in the elderly, in another word ‘immune-aging’. Working in The Jackson Laboratory for Genomic Medicine gives an enormous opportunity to dissect the area of immune-aging by employing cutting-edge functional and genomic tools. Specifically, I am interested to study the alternative splicing of critical genes in the T cell signaling pathways and how such events shape the immune responses of both young and the elderly people. The long-term goal is to understand the ‘sweet spot’ of immune-aging and to improve T cell-mediated immunity in the elderly.

              Download CV

              Aging|Cancer|Immune Disorders|Infectious Disease Research Aging|Cancer|Immune Disorders|Infectious Disease Research The Banchereau Lab Postdoctoral Associate
              Nehar-Belaid Djamel Nehar-Belaid, Ph.D. Farmington, CT
              My main interest is to try to understand how alternative splicing of transcripts can shape the immune response to different type of antigens
              Read less Read more…

              I am a systems Immunologist working in the field of dendritic cells biology. My research focuses on understanding how epigenetic and/or transcriptional modifications occurring in immune-cell populations orchestrate and modulate the quality of the immune response to different type of antigens including pathogens, auto-antigens and vaccines. To try to answer these challenging questions, we are employing a multidisciplinary approach, combining computational methods and cell biology.

              Bioinformatics|Computational Biology|Immune Disorders Bioinformatics|Computational Biology|Immune Disorders The Banchereau Lab Postdoctoral Associate
              Olayan Rawan Olayan, Ph.D. Farmington, CT
              Model disease through aligning human-mouse phenotype data : case study in Alzheimer disease (AD)
              Read less Read more…

              Develops computational approaches using phenotype data to identify complex genetic networks and gene interactions relevant to AD.

              Aging|Bioinformatics|Cancer|Complex Traits Aging|Bioinformatics|Cancer|Complex Traits The Carter Lab Postdoctoral Associate
              Onos Kristen Onos, Ph.D. Bar Harbor, ME
              Studying how different genetic backgrounds and experience mediate disease onset, disease progression and resiliency.
              Read less Read more…

              I currently hold a joint postdoc appointment with Drs. Gareth Howell and Stacey Sukoff Rizzo. My research in the Howell lab allows me to expand my graduate work on memory systems into clinically relevant models of Alzheimer’s disease. I am specifically interested in how genetic context interacts with Alzheimer’s mutations in order to mediate disease onset, disease progression and resiliency.

               My role within the MODEL-AD center (model-ad.org) is with the Preclinical Testing core co-led by Dr. Stacey Sukoff Rizzo and Dr. Paul Territo (IU).  We aim to test therapeutic compounds nominated by the research community in newly generated late-onset Alzheimer’s mouse models. 

              Download cv

              Neurodegenerative and Neuromuscular Diseases|Genetics and Genomics|Aging|Behavioral Disorders Neurodegenerative and Neuromuscular Diseases|Genetics and Genomics|Aging|Behavioral Disorders The Howell Lab Postdoctoral Associate
              Pandey Raghav Pandey, Ph.D. Bar Harbor, ME
              Cardiovascular research focused on metabolic changes that can be altered to prevent disease onset.
              Read less Read more…

              Raghav received his B.S. (Biotechnology, 2010) from Indiana University (Bloomington IN), followed by M.S. (Physiology, 2012) from Indiana State University (Terre Haute IN) where he studied angiogenesis in zebrafish doing cancer research. He received his Ph.D. from University of Cincinnati College of Medicine(Cell Biology, 2017) working on cardiovascular regenerative medicine. His thesis involved looking at microRNAs, stem cells, human-iPS derived cardiomyocytes, and other therapeutics that can be used for cardiac regeneration post ischemic injury.

              Aging|Developmental Disorders|Reproductive Disorders Aging|Developmental Disorders|Reproductive Disorders The Rosenthal Lab Postdoctoral Associate
              Pandey Ravi Pandey, Ph.D. Farmington, CT
              Developing statistical models and pipelines to understand the genetics of neurodegenerative diseases.
              Read less Read more…

              Currently, I am involved in carrying out analysis of large-scale data sets to understand the genetics of neurodegenerative diseases. I will be analyzing data from clinical samples and mouse models of Alzheimer's disease to determine how genetic risk factors lead to dementia. Additionally, characterize the effects on the retina of genetic mutations that increase risk for eye disease. This work will substantially broaden our knowledge of the molecular mechanisms behind common neurodegenerative diseases.

              Previously, I have been working on problems like understanding the evolution of genomes by identification of evolutionary strata in sex chromosomes of mammals, birds and plants using Markov model of segmentation and clustering, which can further help in resolving many epigentics related problems like X chromosome inactivation, Identification of horizontally transferred genes, which can have evolutionary, ecological and potential biotechnological significance in recipient species and more robust taxonomic profiling of metagenomic data. Beside this, I have been also involved in many projects, which were focused on differential gene expression, functional and pathway analysis of NGS/RNA-seq data.

              Download CV

              Bioinformatics|Computational Biology|Neurodegenerative and Neuromuscular Diseases Bioinformatics|Computational Biology|Neurodegenerative and Neuromuscular Diseases The Carter Lab Postdoctoral Associate
              Pettinato Anthony Pettinato, BS Farmington, CT
              My PhD thesis focuses on how patient-specific mutations in the cardiac sarcomere produce genetic and cellular alterations that drive the development of divergent forms of human heart failure.
              Read less Read more…

              My PhD thesis focuses on how patient-specific mutations in the cardiac sarcomere produce genetic and cellular alterations that drive the development of divergent forms of human heart failure.

              Genetics and Genomics Genetics and Genomics The Hinson Lab Postdoctoral Associate
              Powers Natalie Powers, Ph.D. Bar Harbor, ME
              Researching the role of the histone methyltransferase PRDM9 in allocation and repair of meiotic double-strand breaks, which are necessary for the essential process of genetic recombination.
              Read less Read more…

              I am mainly interested in how regulatory and epigenetic factors can influence the inheritance and expression of heritable traits, especially complex traits. My Ph.D. work primarily used human genetic methods, and I joined The Jackson Laboratory to expand my expertise with mice. My current research involves the role of the histone methyltransferase PRDM9 in allocation and repair of meiotic double-strand breaks, which are necessary for the essential process of genetic recombination. In mammals, PRDM9 is responsible for both initiating and localizing the sites of recombination within the genome. I have several ongoing projects in the lab, all of which involve the DNA-binding properties of PRDM9 in vivo, and the roles of PRDM9-dependent histone modifications in recombination.

              Download cv

              Computational Biology|Genetics and Genomics|Complex Traits Computational Biology|Genetics and Genomics|Complex Traits The Paigen Lab Postdoctoral Associate
              Racine Jeremy Racine, Ph.D. Bar Harbor, ME
              Investigating type 1 diabetes and the development of therapies using mouse models of the disease.
              Read less Read more…

              My research involves the development of therapies for treating type 1 diabetes in a humanized version of the NOD mouse. Using NOD mice in which the mouse MHC class I has been replaced with a human variant linked to type 1 diabetes development, I am studying how several therapies can tolerize autoreactive CD8+ T cells selected on the human HLA. The first project revolves around using hematopoietic stem cell transplantation and induction of mixed chimerism to determine how protective MHC can tolerize autoreactive CD8+ T cells. A second project revolves around peptide-microsphere conjugates and how dosing pre-diabetic humanized-NOD mice with diabetogenic peptides can prevent diabetes development, and the mechanisms by which autoreactive CD8+ T cells are tolerized by these peptide-microsphere conjugates. A final side project/collaboration involves dissecting the mechanisms by which IFNϒ can act as an inhibitory cytokine for autoreactive CD8+ T cell expansion.

              Download cv

              Complex Traits|Genetics and Genomics|Resource Development and Dissemination|Diabetes and Obesity Complex Traits|Genetics and Genomics|Resource Development and Dissemination|Diabetes and Obesity The Serreze Lab Postdoctoral Associate
              Reagan Alaina Reagan, Ph.D. Bar Harbor, ME
              I am interested in understanding how age, exercise, and genomic factors influence cerebrovascular function in Alzheimer's Disease and dementia.
              Read less Read more…

              Often dementia presents with a cerebrovascular component that contributes to the development of the disease. However, this area of research is understudied because few mouse models represent vascular decline in a way that mimics the human disease. Using the Howell lab's expertise in mouse genetics and my background in vascular biology, we are testing whether genetic perturbations in vascular development increase the risk for cognitive impairment and dementia with age. Additionally, we are interested in how exercise influences cerebrovascular reserve, and if its implementation reduces risk of cognitive decline and dementia.

              Aging|Eye Research|Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases Aging|Eye Research|Genetics and Genomics|Neurodegenerative and Neuromuscular Diseases The Howell Lab Postdoctoral Associate
              Rosikiewicz Wojciech Rosikiewicz, Ph.D. Farmington, CT
              I am interested in heterogenous nature of cancer, which I am going to study from the epigenomic perspective.
              Read less Read more…

              I have recently finished my Ph.D during which I was studying influence of the gene overlap on the expression level of two protein-coding genes overlapping in cis (aka. natural antisense transcripts). I have studied this phenomenon both at the transcriptional and epigenomic levels. At JAX I have shifted my interest to the latter, epigenomic side of the genome, to study heterogenous nature of leukemia.

              Download CV

              Cancer|Computational Biology|Genetics and Genomics Cancer|Computational Biology|Genetics and Genomics The Li Lab Postdoctoral Associate
              SanMiguel Jennifer SanMiguel, Ph.D. Bar Harbor, ME
              Genetic and epigenetic mechanisms of hematopoetic stem cell identity and function, blood cell development, and blood cancers in the context of aging.
              Read less Read more…

              Jen joined the Trowbridge lab in August 2018. She is interested in the role of genetics and epigenetics in the blood compartment during normal development, aging, and cancer. Jen received her BA from Colby College. She worked for three years at Children’s Hospital Boston in the laboratory of Dr. Louis Kunkel studying muscular dystrophies before joining Dr. Marisa Bartolomei’s lab at the University of Pennsylvania for her graduate training. Jen’s thesis research focused on the epigenetic regulator, Tet1, and its role in development epigenetic reprogramming, specifically in the context of genomic imprinting.

              Aging|Cancer|Genetics and Genomics Aging|Cancer|Genetics and Genomics The Trowbridge Lab Postdoctoral Associate
              Sordo Vieira Luis Sordo Vieira, Ph.D. Farmington, CT
              Building predictive mathematical models to investigate the role of iron and the tumor microenvironment on cancer progression.
              Read less Read more…

              Dr. Sordo Vieira joined The Jackson Laboratory in July 2018 to work in the Laubenbacher laboratory as a postdoctoral associate. His main interests lie in cancer systems biology. He is particularly interested in multi-scale mathematical modeling incorporating genetic and epigenetic data to investigate the role of iron and the tumor microenvironment on cancer progression. He was previously a postdoctoral fellow for one year at UConn Health's Center for Quantitative Medicine working on mathematical analysis of intracellular signaling networks.

              As a graduate student at the University of Kentucky, Dr. Sordo Vieira received the prestigious National Science Foundation Graduate Student Fellowship and proved a major part of an old number theoretic conjecture. He graduated Summa Cum Laude from Wayne State University in 2012 with a B.S. in Mathematics and a minor in physics.

              Download CV

              Bioinformatics|Cancer|Computational Biology Bioinformatics|Cancer|Computational Biology The Laubenbacher Lab Postdoctoral Associate

              Ketan Thakar

              Postdoctoral Associate

              Farmington, CT

              860-837-2077

                Thakar Ketan Thakar, Ph.D. Farmington, CT
                Molecular biologist who is passionate about protein biochemistry, cellular organization and function.
                Read less Read more…

                I am a molecular biologist who is passionate about protein biochemistry, cellular organization and function. My PhD research HDGF, a growth factor known to be involved in cancer formation and progression, showed that it is modified by various post translational modifications which alter and regulate its function.

                The Hinson Lab Postdoctoral Associate
                Tian Cong Tian, Ph.D.
                Studies the development and function of the inner ear.
                Developmental Disorders Developmental Disorders The Johnson Lab Postdoctoral Associate
                Tillman Alisha Tillman Bar Harbor, ME
                Investigating Chk1 Function During DNA damage in oocytes
                Read less Read more…

                Investigating Chk1 Function During DNA damage in oocytes

                Cancer|Genetics and Genomics|Reproductive Disorders Cancer|Genetics and Genomics|Reproductive Disorders The Bolcun-Filas Lab Postdoctoral Associate
                Voigt Anita Voigt, Ph.D. Farmington, CT
                Working on understanding the fundamental roles of the microbiome, particularly the skin and the gut microbiome.
                Read less Read more…

                Anita, a joint postdoctoral fellow with the Oh and Weinstock groups, is most recently from Heidelberg, Germany, where she studied with Dr. Peer Bork and Dr. Magnus von Knebel Doeberitz on numerous microbiome projects related to colorectal cancer and methods development. She is interested in understanding the fundamental roles of the microbiome, particularly the skin and the gut microbiome, in health and disease.

                Download CV

                Computational Biology|Genetics and Genomics|Skin Disease|Cancer Computational Biology|Genetics and Genomics|Skin Disease|Cancer The Oh Lab|The Weinstock Lab Postdoctoral Associate
                Wei Jian Wei, Ph.D. Bar Harbor, ME
                Studies the impact of metabolic pathways and environments on function of immune cells during homeostasis and diseases.
                Read less Read more…

                My background is in lipid metabolism with a focus on exploring genetic reasons and mechanisms of cholesterol homeostasis and metabolic diseases. Currently I have a keen interest in metabolic regulation of immune system. Besides providing energy and fundamental substrates for survival and growth, metabolic pathways and metabolites control fate decision, differentiation, and effector functions of immune cells. We are investigating the role of metabolic evens within immune cells and elucidating how this impacts immune response outcome. In addition, our study lies at how conditions within the tumor microenvironment shape the metabolism and function of immune cells, thereby suppressing immune response. Ultimately, we aim to develop genetic and pharmacological approaches manipulating immune cell metabolism to improve treatment of cancer and immunological diseases.

                Download CV

                Cancer|Genetics and Genomics|Immune Disorders Cancer|Genetics and Genomics|Immune Disorders Postdoctoral Associate
                Wells Ann Wells, Ph.D. Bar Harbor, ME
                Modeling genetic interactions to better understand neurodegenerative diseases.
                Read less Read more…

                I am interested in understanding how genetics and environment interact to influence disease status. I will be using and developing computational tools to understand these complex genetic systems, particularly in the context of neurodegenerative diseases.
                 
                My previous work investigated the role of diet, genetics, and sex on the tissue metabolome. Using metabolomics and various computational and statistical techniques I aimed to understand the complex interactions between diet, genetics, and sex and how each influenced physiological parameters in mice.

                download cv

                Bioinformatics|Complex Traits|Computational Biology|Genetics and Genomics Bioinformatics|Complex Traits|Computational Biology|Genetics and Genomics The Carter Lab Postdoctoral Associate
                Wu Tina Wu, Ph.D. Farmington, CT
                Currently researching the microenvironment of breast cancer, in order to develop new strategies of immunotherapy.
                Read less Read more…

                The human breast cancer microenvironment displays features of T helper 2 (Th2) immunity, which promotes tumor development. We showed that breast cancer cell-derived thymic stromal lymphopoietin (TSLP), by inducing OX40L expression on DCs, contributes to the Th2 immunity conducive to breast tumor development. In order to reprogram the inflammatory pro-tumor Th2 (iTh2) into anti-tumor Th1 microenvironment, we tested the impact of targeting the innate receptors on DCs to render the resistant to tumor environment. We show that intratumoral delivery of β-glucan, a natural ligand for dectin-1 expressed on DCs, blocks the generation of iTh2 cells leading to decreased IL-13 in the tumor microenvironment and prevents breast cancer development. β-glucan exposed DCs expand CD8+ T cells, which produce higher IFNg, Granzyme A and Granzyme B, accumulate in the tumors leading to enhanced tumor necrosis in vivo. Our data demonstrate that exploiting pattern-recognition receptors on tumor-infiltrating DCs enables cancer rejection. We are further exploring the ATACseq and RNAseq approach to understand the regulation of TSLP production in breast tumor cells and how TSLP alters the infiltrating DCs. It can be novel molecular biology approaches to decode tumor infiltrating DCs and T cells and define potential targets for immunotherapy.

                Download CV

                Cancer|Immune Disorders|Genetics and Genomics|Aging Cancer|Immune Disorders|Genetics and Genomics|Aging The Palucka Lab Postdoctoral Associate
                Yang Hongtian 'Stanley' Yang, Ph.D. Bar Harbor, ME
                Determining genetic modifiers/drivers in brain myeloid cells that impact Alzheimer's disease progression
                Read less Read more…

                Brain myeloid cell-mediated neuroinflammation plays a key role in genetic susceptibility and development of dementias, particularly Alzheimer’s disease (AD), but the precise mechanisms are not known. I employ genetically diverse mouse models of AD to mimic the vast amount of genetic variation seen in the human patients. I apply the cutting-edge single-cell RNA sequencing technology together with biochemical and behavioral assays to identify genetic modifiers/drivers in brain myeloid cells that impact AD progression. The ultimate goal of my study is to identify novel therapeutic targets for AD. 

                 

                DOWNLOAD CV

                Neurodegenerative and Neuromuscular Diseases Neurodegenerative and Neuromuscular Diseases The Howell Lab Postdoctoral Associate
                Yi Eunhee Yi, Ph.D. Farmington, CT
                Development of the molecular cytogenetic tool for tracing the extrachromosomal DNA to understand brain tumor heterogeneity and evolution.
                Read less Read more…

                Dr. Yi received Ph.D. in Biomedical Science from Seoul National University, College of Medicine, Seoul, republic of Korea in Feb 2015. She was focused on finding novel biomarker for Glioblastoma using molecular biological approaches. Now, Dr. Yi joined JAXGM with research interest in understanding tumor heterogeneity and evolution.

                Download CV

                Cancer|Genetics and Genomics Cancer|Genetics and Genomics The Verhaak Lab Postdoctoral Associate
                Young Kira Young, Ph.D. Bar Harbor, ME
                Studies hematopoiesis and the molecular basis of aging in the blood.
                Read less Read more…

                Studies hematopoiesis and the molecular basis of aging in the blood.

                Download cv

                Aging|Cancer Aging|Cancer The Trowbridge Lab Postdoctoral Associate
                Zeeshan Saman Zeeshan, Ph.D. Farmington, CT
                Read less Read more…

                Dr. Zeeshan has a PhD in Bioinformatics and her research is aimed at understanding highly aggressive cancers. Associated with “The Cancer Isoform Program” in deciphering the basis of cancer with in-depth isoformic characterization of cancer cells leveraging modern genomic tools with the aim to develop novel therapeutic strategies for precision medicine. Her work is focused on transcriptome profiling of high-grade cancers such as triple negative breast cancer and melanoma that are characterized by a high level of genetic heterogeneity that are not responsive to targeted interventions. 

                As immuno-oncology takes center stage in the battle against cancer, the need for biomarkers has become even more acute. Applying immunoinformatics to studying cancer biology, her work has led her to identify  alternative-splicing alterations in cancer and develop a quantitative, in-depth mechanistic understanding of molecular communication governing the dynamics of the tumorigenesis. Identification of novel signatures at various stages and with different treatments will serve as promising candidates for novel therapeutics as well as biomarkers for precise treatment and management.

                Cancer|Bioinformatics|Computational Biology|Genetics and Genomics Cancer|Bioinformatics|Computational Biology|Genetics and Genomics The Banchereau Lab Postdoctoral Associate
                Zhang Xingmin "Aaron" Zhang, Ph.D.
                Patient deep phenotyping from various data types in electronic health records; phenotype- and genomic-based disease modeling and algorithm development for translational research and differential diagnoses
                Read less Read more…

                Xingmin “Aaron” Zhang, Ph.D. received his doctorate of philosophy in the Cellular & Molecular Biology Program at the University of Wisconsin-Madison in summer 2017. He identified and characterized novel genes that participate in regulated dense core vesicle exocytosis, a cellular process that controls many essential events such as insulin secretion, synaptic transmission and immune responses, through a combination of data driven and web lab-based methods. Dr. Zhang developed a particular interest in combining his training in cell biology and his computational skills to study human diseases. Following his graduation, Dr. Zhang joined the Robinson’s lab as a postdoc to develop computational tools & algorithms for analyzing data from electronic health records (EHR). Dr. Zhang led the LOINC2HPO project that aims at extracting patient phenotypes from clinical laboratory tests in EHR for medical research and differential diagnoses. Dr. Zhang is currently working on harmonizing other data types in EHR and combining genomic information to develop novel algorithms and statistical models to improve human disease diagnoses.

                Bioinformatics|Computational Biology|Genetics and Genomics Bioinformatics|Computational Biology|Genetics and Genomics The Robinson Lab Postdoctoral Associate
                Zhou Wei Zhou, Ph.D. Farmington, CT
                Wei has a strong background in host-microbe interaction and evolution of microbial pathogens. He is interested in developing computational tools to more efficiently characterize the microbiome using metagenomic data.
                Read less Read more…

                Wei is broadly interested in evolution and ecology of microbes in complex communities using genomic methods. Before joining the Oh Lab, he worked with Dr. Dustin Brisson in the University of Pennsylvania to study host-microbe interaction and evolution of microbial pathogens. Presently he is developing computational tools that characterize microbes and microbial interactions more effectively and with less necessary domain expertise.

                Download CV

                 

                Computational Biology|Genetics and Genomics|Bioinformatics|Infectious Disease Research Computational Biology|Genetics and Genomics|Bioinformatics|Infectious Disease Research The Oh Lab Postdoctoral Associate