Lisa Wren, Ph.D, MSCI

Postdoctoral Associate

I am interested in cardiac regulatory and arrhythmia mechanisms, gene therapy and gene editing, and cardiac regeneration with hopes of advancing treatment for cardiovascular disease.

I have 13 years of cardiovascular and translational research experience with my primary projects being centered around cardiovascular genetic disorders, cardiac arrhythmias, and heart failure. Currently, I use advanced proteomic techniques to investigate mechanisms of heart failure and explore novel gene therapy solutions. As a graduate student I studied pathogenic variants that caused severe arrhythmia syndromes in infants and children. I used commercial and patient-specific induced pluripotent stem cell-derived cardiomyocytes and novel mouse models to investigate the cellular mechanisms of arrhythmogenesis. I also explored potential pharmacological interventions to reduce the risk of arrhythmic events. Additionally, I co-authored a paper addressing autonomic nervous system remodeling as an arrhythmogenic substrate in atrial fibrillation. Other previous work contributions include investigating various factors affecting voltage-gated potassium channel stability and investigating the effect of TGFβ signaling on cardiac gene expression in dystrophic mice with developing cardiomyopathy. Outside of research I am an active firefighter, emergency medical technician serving my community. Other previous community experiences include serving as multicultural affairs ambassador for the American Heart Association and a research advocate for the National Multiple Sclerosis Society. Duties included building relationships with community leaders and educating community members on major health topics.


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Education and experience


The Jackson Laboratory
Postdoctoral Associate
Adv: J. Travis Hinson, M.D.
Cardiovascular Genetics

Northwestern University
Ph.D., Life and Biomedical Sciences
M.S., Clinical Investigation
Adv: Alfred L. George, Jr., M.D.
Department of Pharmacology

Jackson State University
B.S., Chemistry


Multicultural Affairs Ambassador
The American Heart Association, Chicago Chapter

Research Advocate
The National Multiple Sclerosis Society, Greater Illinois Chapter

PREP Scholar/Research Assistant
University of Chicago Medical Center
Adv: Elizabeth M. McNally, M.D., Ph.D.

PSOMER Summer Intern
University of Chicago, Pritzker School of Medicine
Adv: Konstantin Birukov, M.D., Ph.D.

Laboratory Assistant
Washington University in St. Louis, School of Medicine
Adv: Jeanne M. Nerbonne, Ph.D.