My research investigates how alternative splicing shapes the chromatin landscape in breast cancer. Chromatin controls which genes are turned on or off, and this structure is maintained by chromatin-modifying factors. I study how splicing changes in these factors can alter their catalytic activity and expression levels, and how these changes, in turn, reshape the chromatin landscape itself. By connecting splicing dysregulation to chromatin biology in breast cancer, this work aims to reveal new mechanisms driving cancer progression and to identify potential therapeutic targets.
