I am interested in understanding how age, exercise, and genomic factors influence cerebrovascular function in Alzheimer's Disease and dementia.
Often dementia presents with a cerebrovascular component that contributes to the development of the disease. However, this area of research is understudied because few mouse models represent vascular decline in a way that mimics the human disease. Using the Howell lab's expertise in mouse genetics and my background in vascular biology, we are testing whether genetic perturbations in vascular development increase the risk for cognitive impairment and dementia with age. Additionally, we are interested in how exercise influences cerebrovascular reserve, and if its implementation reduces risk of cognitive decline and dementia.
University of Oklahoma Health Sciences Center
Adv: Dr. Michael Elliott
JAX researchers find that reducing Hp1bp3 expression mimics age-related cognitive decline through mechanisms reminiscent of aging and...
I'm interested in using computational biology to understand how genetic variation influences diseases and aging.
Uses advanced methods to research glaucoma and other neurodegenerative diseases.
Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.
Our 43-acre Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Scientists here research the...
Researches glaucoma and other neurodegenerative disease, developing new microelectronic devices to monitor/treat disease.
The Jackson Laboratory is an independent, nonprofit biomedical research institution dedicated to the discovery of precise genomic solutions...
JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. Scientists here investigate how...
Gareth Howell named Diana Davis Spencer Foundation Chair for Glaucoma Research
JAX researcher Ron Korstanje is closer to understanding exactly how bear kidneys recover from the damage caused by...
Research overview of The Jackson Laboratory
Investigates the early stages of age-related neurodegenerative diseases.
Areas of interest for me are Immunohistochemistry, microscopy, bioinformatics, statistical analysis, and electrophysiology.
If movies were true to real life, matryoshka dolls would provide a good analogy for genomics research.
Model disease through aligning human-mouse phenotype data : case study in Alzheimer disease (AD)
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