Computational Sciences Staff

Broad experience working with animal model based LIMS systems, including UI design, system architecture and integration, data modeling, and development.  When I started at Jax in 2003, I worked for Dr. Carol Bult in the NMF on the JaxTrack system supporting colony management and phenotyping.  I subsequently joined Computational Sciences, where I worked on the JCMS and JaxLIMS systems.  I spent a few years away from Jax working on a commercial SaaS LIMS system, primarily responsible for system architecture and DevOps. This gave me the opportunity to work with a large number of academic and commercial laboratories doing animal model research, and allowed me to participate in Microsoft engineering workgroups and case studies.  I am excited to be back as a software engineer in Computational Sciences and look forward to working on the Cube initiative.

Bri started with JAX, as an IT Project Manager, in April 2016, where she was involved in many key projects, including the launch of CKB’s public site ahead of the ASCO conference in 2016, aiding MCGI during their establishment, and the implementation of the separate clinical infrastructure at JAX Genomic Medicine in Farmington. Bri most recently supported the IT infrastructure team with multiple cloud based collaboration initiatives aimed to improve the means by which our staff collaborate; not only with each other, but external partners and researchers around the globe. These initiatives involved enabling the secure use of Google Genomics Cloud Platform, implementing Webex for video and audio collaboration, migrating TIS to Webex from Adobe connect for their educational Webinars, and bringing JAX a secure, cloud based storage solution that can be accessed from any device anywhere in the world with Box.

Bri has been a project manager since 2011, working in various fields including insurance, pharmaceuticals, and manufacturing, and holds a BS in Physician Assistant Studies, Public Health, and Related Clinical Sciences.

She is looking forward to bringing her skills to the Computational Sciences department.

I hold a PhD in bioinformatics and Computational Biology with a minor in Statistics. For my dissertation work, I established the essential bioinformatics infrastructure in functional genomics studies using metabolomics as a systems biology tool. I have utilized Mass spectrometry for developing Human Embryonic (hES) and Induced Pluripotent Stem (IPS) cells based assays for drug toxicity screening, for developing a test for biomarkers of autism using patient’s blood and for detecting bio-markers for Escherichia coli O157 infection in cattle from blood samples. I am currently developing a computational metabolomics platform to analyze and visualize mass spectrometry based metabolomics data in JAX. In addition to metabolomics, I am gaining experience in next generation sequencing technologies and cloud computing by developing a tumor neoepitope prediction pipeline for personalized medicine.

Well-organized and proficient at multitasking and prioritizing. Hardworking, dedicated professional with extensive experience in Office Administration/HR Management. A strong work ethic with a commitment to integrity and excellence. A team player fostering trust and building strong relationships. Ability to work in any organization. I have provided administrative support for High Level Senior Directors. Expert in submitting Concur requests. Prescreens all candidates via phone and face-to-face interviews. Onboarding of new and exit interviews with departing employees. Equipment and software procurement. Video/room conference scheduling across multiple locations. Monthly reporting including transaction research. Expense submission and reimbursement. Partner with Human Resources.

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I am a software engineer with a background in High Performance Computing. I have developed parallel software (both multi-threaded and distributed with MPI) in a variety of languages including C, C++, and Python. In addition to HPC projects, I have developed a variety of analysis and data management tools in Python (both web applications and command line).  I have also helped design and am currently the primary maintainer of the Civet pipeline framework, which drives analysis pipelines used for the JAX Cancer Treatment Profile and PDX.

I have a B.S. in Applied Mathematics from NYC College of Technology. I started my time at Jax in 2014 as a Software Quality Assurance Intern, joined Computational Sciences as an Associate Scientific Software Engineer in 2016 and became a Scientific Software Engineer in 2018. I'm a "full-stack" engineer who works on a variety of problems including genomics algorithm optimization in C/C++, RESTful API design and implementation using Flask, software reliability engineering, cloud computing, and project and systems design. I'm currently pursuing an M.S. in Computer Science as a member of the inaugural class at The Roux Institute at Northeastern.

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 Alex Berger on GITHUB 

I received my M.S. in Computer Science and Engineering and B.S. in Ecology and Evolutionary Biology from the University of Connecticut researching biological databases and ontologies. For over ten years I have been leading the development of web applications for multiple Fortune 500 companies in a number of industries including environmental safety, facility maintenance, and media.

I am excited to be bringing my research and industry experience to The Jackson Laboratory community and contributing to the development of robust, innovative software designed to help us solve some of the most complex problems facing the biomedical community today.

From the early days of my career, while designing and writing programs, from assembler, to C++, to SQL, to JAVA/J2EE, to NoSQL, to front-end JavaScript framework languages; my passion has been Software Development and Architecture, and the interesting study of surging technologies thereof.

My professional background includes experiences in various industries and in diverse capacities which have giving me the opportunity to understand end-to-end intricacies of software development life cycles and software platforms. During my career, I have had the opportunity to plan, architect, develop, and lead software projects and teams with the ultimate goal of providing solutions that meet and exceed stakeholder’s expectations. My 15 years of work experience includes serving in various arenas, such as Supply Chain, E-Commerce Software Platforms, and Insurance industries

I recently joined JAX, and I am absolutely thrilled with the opportunity to contribute to the goal of research for tomorrow’s cures and personalized treatments. The world of genome research and bioinformatics is absolutely fascinating, so I am enthusiastic to apply my skills and to broaden my knowledge as a dive deeper into this great domain and inspiring cause.

I hold a Masters in Bioinformatics minor in Health Informatics. My dissertation revolved around literature based discovery utilized to mine existing drug interaction evidences in the clinical trial Phase I and II studies and predicting novel drug interaction signals with mentions of adverse related events. Few interesting projects during my masters includes mining the highthroughput data to understand changes in gene expression, methylation and variant profiles in cancers such as Glioblastoma Multiforme and lung cancer using the computational methods and systems biology approaches. My research interests are to apply computational and machine learning approaches to understand the molecular mechanisms and biological complexities in tumors leading to better prediction of treatments.

I hold a Ph.D. degree in biophysics from Rice University with a focus in gene expression network analysis and neural network analysis. I developed models to study how biological structure spontaneously arises in an evolving system. After Ph.D. I worked as a data engineer at Two Sigma Investments,I built tools to automatically acquire, process and visualize financial data and maintained database used for trading and research.

I received my PhD in genetic epidemiology from the School of Medicine, University of Queensland, Australia, researching the genetic and environmental influences of obesity in Australian twin families. I completed post-doctoral positions at the University of Hong Kong working on founder mutations in Hirschsprung’s Disease in Han Chinese, and at the Singapore Eye Research Institute where I investigated the genetic variants linked to age-related macular degeneration and the role of endophenotypes in glaucoma in the three major ethnic groups in Singapore – Malay, Indian and Chinese. As a researcher at the Massachusetts General Hospital, I used exome chip and targeted sequencing data from related and unrelated individuals to identify novel genetic variants responsible for Type 2 Diabetes through their association with related quantitative phenotypes.

At the New York Genome Center, I was a senior bioinformatics scientist in genetic epidemiology and statistical genetics responsible for ensuring the integrity as well as the analysis and interpretation of pedigree-based data. I also provided lead support to several large ongoing projects which used sequencing and chip data to more precisely localize and characterize genes underlying previously identified variants in diverse ethnicities and races including African Americans, Puerto Ricans and Europeans. Before joining JAX, I was a population informaticist and team lead at Sema4, building out the molecular ancestry calculation pipeline for the expanded carrier test using new genotype technologies.

Belinda Cornes on Google Scholar

1. Worked as QA Lead at Schlumberger to manage, co-ordinate and test real time Data Acquisition System for Oil Exploration involving multiple applications controlling Equipment Operations.
2. Performing Automation testing on software Products and updating Test Scripts as functionalities evolve.
3. Worked At HP as QA Lead to manage and plan testing for Network Controllers, Storage Controllers and HP E-Commerce website.
4. Worked with Project Managers, Developers , System Architect to define and customize QA process for Agile as per project needs.

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Previously, I have worked on design and development of scientific software solutions using complex algorithms, statistical analysis, machine learning, and NLP. As a recent addition to the Computational Sciences group here at JAX, I am thrilled to utilize my skill set and widen my understanding as I uncover more about the world of genetics, genomics, and bioinformatics.

A synthetic organic chemist by training, I spent the first few years of my career at the bench.  I've been working as a software engineer for more than 15 years, with the last 10 years focused on delivering applications that help enable scientists.  Prior to joining JAX, I spent time at the Broad Institute and was exited to be part of a team that worked to deliver the BioAssayResearchDatabase.  Since joining the Computational Sciences group here at JAX, I've worked closely with Clinical and was excited to lead the software team that built JAX-Clinical Knowledgebase (CKB) (https://ckb.jax.org/).

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I'm interested in how to leverage open-source software to help advance scientific research. An active contributor to open-source projects, I contributed to the development of data analysis tools used in synchrotron experiments. I am now a member of the Computational Science team at JAX working on tools used for genomic science.

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Baha El Kassaby on Research Gate

My professional career started in the US Army Corps of Engineers. While stationed in Alaska, the Marshall Islands, the Republic of Korea and Iraq, I worked as a construction engineer, project manager, explosives and demolitions trainer, and logistics officer. After military service, I have been involved in both the worlds of startups and academia. I have led projects in a variety of fields including: hydrologic warning, field maintenance operations, crisis informatics, oceanographic event analysis, and software development. I have also been an assistant instructor in the Department of Spatial Information Science and Engineering at the University of Maine.

I hold a B.S. in mechanical engineering from the U.S. Military Academy at West Point, and a M.S. in environmental engineering from the the Missouri University of Science and Technology.

I received my Ph.D.in physics from Rutgers University – New Brunswick in October 2017. During my Ph.D. work, I used machine learning to understand complex epistatic interactions among networks of correlated amino acid substitutions in protein sequence alignments, and I built distributed computational grids to run large parallel molecular dynamics simulations of protein-ligand binding. Here at JAX, I will apply machine learning techniques to new problems at the forefront of genomics and molecular biology.

Bill Flynn on Google Scholar

I am a software engineer, working to make a difference where biology and computer science meet. I specialize in full-stack web applications, scripting, and bioinformatics related technologies such as bioPerl, bioPython, and NGS frameworks. I have additional interest in machine learning and data mining algorithms. I aim to bridge the gap between the vast amounts of data and the need for results or visualizations.

My interests include computational methods to estimate the genetic, epigenetic and transcriptional profiles of cells involved in disease like cancer and diabetes. Currently we are able to profile the transcriptional and epigenetic profiles of the cells involved in these diseases at single cell resolution.  These technologies generate huge amount of data and there is an urgent need to develop novel methods to analyze these data to generate biological insights.

I also coordinate the efforts to characterize the genome of patient-derived xenograft (PDX) models developed at JAX. PDX models are essentially human tumors engrafted in immunodeficient mice and are excellent models to study therapeutic response to cancer. We assess the genomic mutations and gene-expression profiles of these tumors using next-generation DNA sequencing technology.

As a Scientific Engineer, my goal is to advance software projects that accelerate development of biological technologies. As a result, my work sits at the intersection of computational biology, neuroscience, data science, and software engineering. I have extensive experience in biological signal and image processing and enjoy creating modular and scalable software solutions to explore scientific questions. In my spare time, I enjoy exploring the natural wonders of New England.

I've worked with groups that have developed scientific database-driven web resources and software applications to support biomedical research, clinical trials, and biometry.

I focus on 1) developing computational methods to systematically and accurately characterize the genomics and the transcriptomics of cancer using high throughput sequencing technology, and developing integrative approaches that help understand the etiology of cancer. Translate of genomics into therapeutics and diagnostics reinforce its potential for personalizing medicine.

2) computational analysis from genomic sequences to other post-genomic data, including both DNA and RNA sequences, protein profiling, and epigenetic profiling, in an ongoing effort to find hidden treasures. With the development of next-generation sequencing, our understanding has been advanced through the use of a variety of platforms: methy-seq, ChIP-seq, exome-seq and RNA-seq. The large amount of publicly available next-generation sequencing data, such as datasets from TCGA and ENCODE, has created enormous opportunities for researchers to conduct genomic analysis beyond the traditional sequencing analysis. Transforming genomic information into biomedical and biological knowledge requires creative and innovative computational methods for all aspects of genomics.

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I hold a PhD in Molecular Biology from the University Texas at Dallas and postdoctoral research expertise in functional genomics and transcriptomics from The Scripps Research Institute (TSRI), Jupiter, Florida. A molecular biologist by training, I worked to see how small RNAs fold and big RNAs control gene expression and cellular functions, especially in human diseases and disorders. In addition to see how smart RNAs are, I am interested to apply the project and people management methodologies applied in the business/industrial world to the scientific research environment. I worked as a Project Manager at Rice University, Houston, Texas, to develop a Web platform for data collection for scientific research.

At JAX, I am part of a robust team at the Computational Sciences (CS) where I collaborates with the faculty, software developers, and computation scientists- who are dedicated to find novel solutions in the fight against diseases such as cancer and Alzheimer's using cutting edge computational and genomics technologies. As a Project Manager, I supports the CS team to plan, facilitate, execute, and deliver projects within agreed-upon timelines, resources, and objectives.

My primary responsibility is to direct R&D operations of Computational Sciences (CS) at The Jackson Laboratory. CS works with our collaborators and partners at all campuses of The Jackson Laboratory and the expertise of CS spans the whole landscape of bioinformatics.

My research interests are in developing and applying statistical bioinformatics methods, machine learning algorithms and network biology approaches to understand disease biology and model biological processes such as cell division cycle and DNA replication.  We mine integrative heterogeneous omics data analysis and modeling as basis for our research.

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Krishna Karuturi on Google Scholar

  Krishna Karuturi on Researchgate 

Studies the complex biological processes using machine learning and physics-based dynamical (linear/nonlinear) models using data-driven analysis. Develops computational methods, tools, pipelines, and interactive web apps to construct, model, simulate, and visualize the gene regulatory networks in various biological processes using literature-based evidence as well as RNA-Seq (bulk/single-cell), ATAC Seq, and CHiP Seq data. Employs deep learning on video-based assays and genomics data from behavioral studies to connect behavior and genetics.

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          Vivek Kohar on ORCID        

My primary focus at JAX is on developing data management systems and tools for the exploration and visualization of complex biological data and its interpretation. As part of a multidisciplinary team at JAX, I frequently collaborate with both experimental and computational scientists on data analysis and visualization projects. 

In my role as a Scientific Software Engineer, I am leading the JAX Synteny Browser, a novel tool for interactive visualization of regions of conserved synteny between two genomes based on their biological properties such as function and phenotypes. 

Another hallmark initiative that I am closely involved in is JAX’s Patient–Derived Xenografts (PDX) program, a platform for data management, visualizations, analysis, reporting of cancer models studies. I lead the implementation of interactive visualizations for cancer treatment response studies (SOC) and develop automated software to run robust pipelines for the analysis of genomic variations in cancer models. 

I am also a key member of the Mouse Phenome Database (MPD) project, an integrated platform to explore physiology and behavior through genetics and genomics, for which I create highly interactive data visualization tools using the latest cutting edge and open source technologies. 

In addition, I also teach several data science and programming courses/workshops at JAX on coding skills in R, Python and SQL.

I have a strong background in computational biology/bioinformatics with specific expertise in single-cell sequencing technology. I have analyzed transcriptomes as well as genomes of thousands of single cells from a range of cell types, including cancer, induced pluripotent stem cells, neuronal cells, blood cells, ovarian cells for various studies identifying gene signatures and/or mutations specific to particular cell types. I have also been involved in the development of a computational approach to support the design and analysis of single cell RNA-seq experiments. Separately, I have also analyzed bulk transcriptomes/genomes either for comparison with single cell studies or for independent research projects.

I work on teams to develop and improve internal software-based tools used by researchers within the lab. I am also involved in the JAX Diversity Strain Informatics project which will bring everything regarding CC/DO mice into one space where the scientific community can access data, tools, and educational resources. Most of my work is front-end, utilizing tools like D3, and UI/UX, but I'm always looking to improve and expand my knowledge to work towards becoming a full-stack developer.

My primary languages and tools are: Javascript, Python, HTML/CSS, D3, Sketch

I pursued my PhD study in Computer Science (specifically, statistical machine learning) from 1997-2000 at National University of Singapore. During this period of time, I not only worked in machine learning theory, but also designed and implemented a new family of online learning algorithms to recognize the handwriting digits in MNIST dataset, and obtained the state-of-art performance that could be achieved by online learning algorithms at that time.

From 2001-2003, I worked on microarray gene expression data. The methods I explored included supervised classifications via relevance vector machines and unsupervised class discovery. Since 2004, I have been working in statistical genetics -- dissecting genetic bases for complex human diseases by analysis of genome-wide linkage and association data, exome-wide sequencing data, RNA-sequencing data. Since the genetic variants far out-numbered the sample size, various statistical methods, including data imputation, regularized regression, generalized linear mixed models, pathway analysis, fine mapping and evidence combination from heterogeneous data sources, have been explored and developed.

I have published more than 40 peer-reviewed papers in various journals, including first or co-first author publications in Nature Genetics, American Journal of Human Genetics, Machine Learning, Journal of Computer and System Sciences, and IEEE Transactions on Information Theory.

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Yi Li on Google Scholar

During my Ph.D., I developed extensive experience in analyzing the next-generation sequencing data and developing computational methods. My research fields include but are not limited to RNA secondary structure, RNA binding protein regulation, mRNA translation, non-coding RNA, developmental biology, virus infections, and cancer. I have extensive experience in processing and analyzing the next-generation sequencing data which includes iCLIP/eCLIP-seq, RRBS, ic/SHAPE, PARS, ribosome footprinting, RNA-seq, and so on. I developed PRAS for CLIP-seq data to detecting the functional targets of RNA binding proteins.

Jianan Lin on ORCID

I recently joined the Jackson Laboratory having previously worked on a diverse set of organisms. My Ph.D. focused on population and conservation genetics of a submersed aquatic plant species, which was targeted for restoration efforts. Most recently, I was a member of the Department of Entomology at the Smithsonian Institution. In that role, I was responsible for the generation and analysis of target enrichment data used in phylogenomics. These studies spanned a number of insect orders and also included ant-associated fungi. I am excited to apply my knowledge and skill set to the diversity of questions being asked at JAX.

My academic training is in physics and mathematics. I completed my PhD in math at Dartmouth College in 2009. After graduate school, I expanded into systems biology with a postdoctoral fellowship in the genetics department at Dartmouth studying an autoimmune disease called systemic sclerosis. I subsequently took a second postdoc in systems neuroscience studying the coordination of neuronal firing underlying cognition and cognitive deficits in epilepsy models. While seemingly disparate, these two fields share a lot in common from the mathematical point of view, particularly the use of machine learning and network theory to cope with biological complexity. For the last several years, my interests have expanded into model systems genetics and the central problems of predicting causal genes for complex traits and defining robust phenotypes for genetic mapping using heterogeneous data. My current work is expanding these approaches for the Cube project and through several ongoing collaborations within and beyond JAX.

I have always been interested in biology but found my skill set tended more towards math and data science. After graduating with a B.A in Mathematics in 2016 I joined a computational biology lab as a research assistant, there I developed experience working with deep neural networks for image feature extraction, as well as the modeling of single unit neuronal recordings. In 2020 I was excited to accept a full time position in the Computational Sciences Core leveraging my previous experience.

Seamus Mawe on ORCID

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I am a Computational Scientist at the Jackson Laboratory @ Farmington, USA. I have several years of professional experience in Computational Biology, Bioinformatics, Statistics and Biostatistics. I have mainly authored publications on bulk- and single- cell transcriptomics (RNA-seq, CAGE and Microarrays), 3d chromatin organization, signal processing and image analysis. I have worked in cancer stratification and cell cycle, mast cell trascriptome, type 2 diabetes and, more recently, on heart disease, cardiac (trans)differentiation and characterization of myocyte and non-myocyte populations. Currently, I am mainly working on the single-cell transcriptomics and epigenomics of type 2 diabetes.

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 Efthymios Motakis on ORCID

I received my PhD in Integrated Biomedical Science, concentration in cancer biology, from Ohio State University and my MS in Biomedical & Health Informatics from University of Washington.  During my PhD, I focused on mouse genetics and genomics from the perspective of a bench scientist; my dissertation work involved investigating mutation types and numbers in preneoplastic cells and tissues from Fhit knockout mice.  I completed a postdoctoral fellowship and MS degree simultaneously at the University of Washington where I investigated differential gene expression in the parasite Leishmania donovani.

I recently joined Jackson after many years of diverse commercial software development, including consumer, professional and medical software and firmware.  Most recently I worked on a team that developed image processing algorithms for detection of physical features in coronary OCT (optical coherent tomography) scans.  Prior to that I developed the image processing chain for a disposable endoscope used for direct visualization of pancreatic ducts.  For this product I also designed the control feedback algorithm for automatic illumination control.  I also worked on the image processing chain for an optical particle analysis system.  While the system had its origin in marine biology research, it's also been used in pharmaceutical and industrial applications.  Prior to working with the scientific and medical communities I worked for many years in commercial mapping.  In addition to developing consumer and professional mapping applications, I also developed the software for a multi-sensor 360-degree panoramic camera.  The purpose of this camera was to collect mapping data from a moving terrestrial platform to complement data collected from the aerial platforms.  I look forward to applying these experiences to the diverse problems at Jackson.

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I hold a PhD in Life Sciences from University of Tennessee/Oak Ridge National Laboratory Genome Science and Technology Program, with a focus in statistical and quantitative trait genetics of behavioral traits in genetic reference populations and integrative functional genomics of behavior across species and experimental platforms. During my Ph.D. program I investigated the increased precision and resolution in QTL mapping using mouse reference populations including the expanded BXD recombinant inbred (RI) strain panel and the Collaborative Cross (CC) reference population The BXD RI study highlighted the increase in statistical power obtained in using the expanded BXD RI strain panel. The CC study highlighted the increased allelic variation and QTL mapping precision achieved. Upon completion of my Ph.D., I joined the Computational Sciences - Statistics and Analysis group at The Jackson Laboratory in 2012 as a biostatistician, with responsibilities including QTL analysis, expression QTL analysis, gene expression analysis, statistical modeling of diverse biological datasets, and statistical consulting. In addition to my contributions towards the field of quantitative trait genetics and statistical genetics, I have undertaken several other data analysis tasks involving differential gene expression analysis using next generation sequencing technologies, leading to the generation of new or validation of existing hypothesis.

For a complete list of my published work, please visit my NCBI bibliography.

Over the past ten years, I specialized myself in big data analysis (i.e. Machine-Learning) applied to Genomics, Semantics and Next Generation Sequencing (NGS) data linked to single-cell and cancer research. I obtained my PhD in Computational biology and Evolutionary Genomics at Ecole Centrale de Lyon (Lyon University), France. I worked both in academics (University of Hawaii Cancer Center, UCSD) and in a Startup company (R&D engineer) developing and using my research skills on fundamental and more concrete problematics. My current work involves working with single-cell ATAC-Seq and RNA-Seq datasets, multi-omic datasets linked to survival, new methods, pipelines and data visualisation interfaces development.

         Olivier Poirion on ORCID         

Oliver Poirion on Google Scholar

Over 15 years of multi-faceted, cross-functional experience in managing and analyzing data generated by diverse high-throughput genomic technologies. Hands on experience and leadership in genomics, big data management, analysis pipelines, interpretation and application development in academic, government and commercial settings.

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KUNDE GOVINDARAJAN ON GOOGLE SCHOLAR

  KUNDE GOVINDARAJAN ON RESEARCHGATE  

With a background in Biology (Argentina), I've been working in Genomics and Bioinformatics since 2009, when I started my PhD Fellowship at the University of Salamanca (Spain). Since then, I've been fascinated about using information technologies for decoding the complexity of life. I've been working in the bioinformatics side of a wide variety of projects, such as investigating pathogenicity genes in pathogenic fungi and bacterias, exploring the use of miRNAs as biomarkers in cancer or exploring the functional role of transposable elements. All these projects have had required not only an effective data management and processing of the sequencing data, but also a comprehensive understanding of the state-of-the-art computational methods.

At JAX I work closely to Genome Technologies Team in developing and applying the most innovative bioinformatic methods for analyzing data generated with the cutting-edge genomic and sequencing technologies.

Gabriel Rech on Research Gate

        Gabriel Rech on ORCID        

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My past research focused on combining experiments in natural and constructed populations with high-throughput genetic, genomic, and transcriptomic analyses to better understand the current and historical forces that have shaped the evolution of traits, and using those patterns to infer what changes may occur in the future. In my new work at JAX I plan to leverage the knowledge and experience I gained through my academic research to help with the diverse projects that are being conducted to help improve our understanding of the relationships between our genes, environment, and health outcomes.

Brian Sanderson on ORCID

Recent advances in DNA sequencing technology led to the generation of vast amount of sequencing data and provided an unprecedented opportunity to understand the complexity of genome. However, this massive flood of sequencing data also created challenges in mining patterns of interest from this data. Moreover, diversity of datasets [RNA-SEQ, ChIP-Seq, Exome etc] generated from these technologies also demand more integrated evaluation across various sequencing platforms and data types. My dissertation was focused on deriving meaningful patterns from these datasets generated from both model and non-model species and also studying the variations in non-coding RNA (ncRNA) secondary structure and developing a novel method for ncRNA detection in the genome using patterns of chromatin-modifications. My post-dissertation work primarily concentrated on developing systems/algorithms to effectively analyze next generation sequencing data involving mammalian genome.

I joined The Jackson Laboratory's Computational Sciences Department to become the Deployment Lead in the Lab’s involvement in the NCI Cancer Biomedical Informatics Grid® (caBIG®) initiative and stayed on as a member of the Stats and Analysis group. My background in protein and genomic databases and conceptual representations of life sciences research has enabled me to contribute to the clinical and the PDX programs. I continue to gain experience in analysis of next generation sequencing, calling on my history of bench research in cancer, pharmacology, and transcriptional regulation. I have experienced the roller coaster ride of small start up companies and welcome the opportunity to be part of the JAX community. On any given day, I may spend time wrangling data for PIs or collaborators, launching a DNA-seq analysis, tracking down data for a potential PDX customer and checking out a new analysis tool or online database.

My initial contributions to science were the result of a Master of Science education program (University of Illinois - Champaign-Urbana) endeavor to identify quantitative trait loci affecting swine meat characteristics. Shortly after my leave of the University, I joined The Jackson Laboratory in 2007.  The numerous collaborations that took place at the Laboratory have resulted in publications pertaining to a variety of conditions including: alopecia areata, asthma, cancer (of the brain, lung and skin), diabetes, chronic kidney disease, eye disease, and reproductive disorder. The general aim of these studies is to provide mouse model information as a  method to improve human health.  My role in these studies has been as a biostatistician consultant. 

For a complete list of my published work, please visit my NCBI bibliography.

Ms. Sundberg has been involved with computer applications for 40 years. She developed herd health management software in 1976, a database for managing pesticide chemicals for the state of Indiana in the mid 1970s, and worked on various other projects for the Administrative Data Processing Center at Purdue University. During the past thirty years she has worked on a project for managing mouse breeding colonies (JAX Colony Management System, JCMS) and a relational database for medical records management (The Mouse Disease Information System, MoDIS). MoDIS was developed in 1987 to manage histopathological data from The Jackson Laboratory massive mouse production colony as well as research data. Over the years this evolved to integrate the Mouse Anatomy Ontology (MA) and Mouse Pathology Ontology (MPATH), to eventually provide an integrated tool for storage of basic research discoveries, linking gross and photomicrographs to case materials, and getting this information into publicly accessible databases such as Pathbase (http://www.Pathbase.net), and Mouse Genome Informatics (http://www.informatics.jax.org/). Currently she is working with the Computational Sciences PDX (patient-derived xenograft) platform team of software engineers.

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I joined JAX as Associate Scientific Software Engineer in Computational Sciences department. I will be focusing on CKB project (Clinical Knowledgebase) for Clinical Curation and Analytics.

Previously in my career I worked in e-commerce and insurance industries focusing on consumer facing applications. I had an opportunity to be involved in architecture design, development and maintenance phases of the applications. Also worked closely with business partners to understand customer experience in the end product and identify ways to improve customer experience as well as improve technical side of the applications.

I am excited and looking forward to how can I apply my skills at JAX and contribute into its great mission.

I am 25+ year technology and research management professional with experience in leading complex programs in the life sciences. I have, extensive knowledge of program leadership, research project management, information technologies and molecular biology and genetics combined with outstanding communication, analysis and collaboration skills results in transformative team data science.

I am a full-stack principal level scientific software developer with a passion for software development that enables scientific research. I have over two decades of experience in a variety of industries, with a focus in biotechnology.

My primary development tools include: Python, Java, Groovy, AngularJS, JavaScript, D3, Bootstrap, PostgreSQL, MySQL and Oracle. I have worked on large scale enterprise LIMS for collecting, tracking, processing and reporting patient samples; command-line analysis tools for scientific data; web applications for the presentation of analyzed results; and API’s to allow other programs access to data and tools using RESTful web services and JMS.

My role at Jackson Laboratory is one of technical leadership on multi-developer projects, using agile techniques, striving to provide meaningful/usable systems in a timely manner.

Emerging single-cell transcriptomic and highly-multiplexed imaging methodologies are advancing our basic understanding of tumor heterogeneity and its impact on patient outcome and therapeutic response. My previous work involved predicting disease progression and drug response using bulk (principally, expression) data. My interests lie in leveraging these new single-cell modalities to improve our ability to extract insight from the wealth of existing (and clinically annotated) bulk data. For example, we have recently completed a deconvolution DREAM challenge comparing methods that infer immune sub-populations from bulk expression data. Several participant methods used single-cell RNA-seq to identify markers that could subsequently be used to detect the corresponding population in bulk data.

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Brian White on ORCID

I have a diverse expertise in analysis of Multi-omics datasets, Immunology, Microbiome, Developmental Biology, RNA biology and Cloud Computing. During my Ph.D. I studied the downstream targets of Hox genes in developing hindbrain using mouse, zebrafish and chick models. My postdoc was focused on developing Bioinformatics pipelines for the analysis of microbiome data and various immunological studies. Currently I am developing pipelines for identification of lncRNAs and splicing events in RNA-seq datasets and integrating various omics data.

Marina Yurieva on ORCID

My research mainly focuses on genetic dissection of complex diseases using/developing the state-of-the-art multi- and inter-disciplinary approaches of genomic technologies, and statistical and bioinformatical methods. The approaches involve genome-wide association analyses, genome-wide transcriptome analyses, proteome-wide protein expression profiling, epigenetic profiling by various statistical methods, including e.g. data imputation, regularized regression, pathway analysis, fine mapping. I am also extending our research of complex diseases to systematically and accurately characterize complex disease. I am interested in developing novel statistical methods and bioinformatics tools for integrating large, complex multi-omics datasets (e.g. DNA-Seq, RNA-Seq) in research. e.g., I performed integration analysis for cancer at micro-RNA, mRNA, DNA methylation levels. In addition, I am interested in how to transfers knowledge from my basic research to clinical research.

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Solving computational biology and bioinformatics problems with machine learning and statistical methods.