My research mainly lies in developing and applying statistical and system computational approaches to discover complex disease mechanisms, biomarkers and treatment targets by integrate large-scale biological “omics” data.
My research mainly focuses on genetic dissection of complex diseases using/developing the state-of-the-art multi- and inter-disciplinary approaches of genomic technologies, and statistical and bioinformatical methods. The approaches involve genome-wide association analyses, genome-wide transcriptome analyses, proteome-wide protein expression profiling, epigenetic profiling by various statistical methods, including e.g. data imputation, regularized regression, pathway analysis, fine mapping. I am interested in developing and applying statistical methods and bioinformatics tools for integrating large, complex multi-omics datasets (e.g. DNA-Seq, bulk RNA-Seq, sc/snRNA-Seq) in research, e.g. Alzheimer's disease and cancer.