Investigates the mechanisms and consequences of genomic rearrangements with a focus on repetitive elements. These lines of inquiry could find regions prone to instability in human cancers and lead to targets for therapy.
Metabolomics for precision medicine; ImmunoMetabolomics and multi-omics modeling of immune system. This revolutionary information fills a major gap between genome and environment, with broad applications to diseases and precision medicine.
Develops novel mouse models of human disease and provides these resources to the scientific community. Employs conditional mutagenesis and forward genetics to interrogate the role of individual genes in development and disease.