Patient-Derived Xenograft (PDX) Models

Over 300 patient-derived xenograft (PDX) tumors are available for engrafting into immunocompromised NSG™ mice for shipment to your facility or use in JAX-directed preclinical efficacy studies.

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JAX has partnered with more than 20 cancer clinics to provide access to a wider range of patient-derived xenograft (PDX) cancer models at earlier passage numbers than any other PDX collection available today.

JAX PDX Resource: Development Process

PDX diagram

More than 350 unique PDX oncology models from both treatment naive and resistant patients have been established in the highly immunodeficient NSG™ (005557) mouse strain. NSG™ mice engraft primary human tumors that, after low passage, retain the genetic and phenotypic heterogeneity typically seen in human cancers, offering a distinct advantage over other PDX hosts. This preclinical platform can predict the effectiveness of novel therapeutics to treat patients with cancer. We can conduct preclinical efficacy testing with customer-provided compounds at JAX using any of our PDX cancer models or ship PDX tumor-bearing mice to your facility.

PDX Live™ tumor models

Our collection of readily available, off-the-shelf PDX tumor-engrafted cohorts can help you put mice on study sooner, allowing rapid study turnaround and faster decision-making.

See our inventory of PDX Live™ tumor-bearing mice

A complete PDX cancer resource

These tumors types are available for engraftment in NSG™ mice for shipment of tumor-bearing mice to your facility or for execution of efficacy studies performed in our facility by our oncology scientists:

Bladder cancer

We provide access to many bladder cancer PDX models, including muscle-invasive options. Models are currently available for efficacy testing of your candidate compound by our study directors or for distribution to your facility. For most of our bladder PDX tumors, gene expression data and genomic data, standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Featured bladder cancer PDX models

Model name Diagnosis Known mutations
TM00013

Urothelial Carcinoma

Genomic and other data

TM00014

Urothelial Carcinoma

Genomic and other data

TM00015

Urothelial Carcinoma Invasive

PIK3CA, TP53 variants

TM00016

Urothelial Carcinoma Invasive

RB1, TP53 variants

TM00017

Urothelial Carcinoma

Genomic and other data

TM00018

Urothelial Carcinoma

Genomic and other data

TM00019

Urothelial Carcinoma

Genomic and other data

TM00020

Urothelial Carcinoma

TP53

TM00021

Urothelial Carcinoma

ATM

TM00023

Urothelial Carcinoma

Genomic and other data

TM00024

Urothelial Carcinoma

TP53; Variant and other data

TM00025

Urothelial Carcinoma

FLT3

TM00026

Urothelial Carcinoma

PTPN11

TM00031

Urothelial Carcinoma

Genomic and other data

Additional bladder cancer PDX models are available in the Mouse Tumor Biology Database.

The histopathology images shown below reveal that the overall morphology and structure of JAX PDX tumors, engrafted in NSG™ mice, which are maintained at low-passage resemble the primary tumor from patients. The images below correspond to a primary tumor high-grade invasive urothelial bladder carcinoma (TM00016-PT) and the corresponding low-passage PDX tumor (TM00016-P1).

TM00016-PT

Breast cancer

Over 20 unique breast cancer PDX models are currently available within our PDX model cancer collection, including the most common and therapeutically relevant breast cancer diagnoses. Our models using NSG™ (005557) mice have distinct advantages as hosts for human breast tumors, preserving the biological characteristics of the original tumor. In addition, NSG™ mice support the robust growth of ER+ breast tumors that historically have been difficult to develop using other mouse models.

Breast cancer clinical markers:

Additional breast cancer models are available in the Mouse Tumor Biology Database. Mice engrafted with breast PDX samples are available for efficacy testing at JAX In Vivo Services or for distribution to your facility. For most of our breast PDX tumors, gene expression data and genomic data, standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Featured breast cancer PDX models

Model name Diagnosis Tumor markers Additional detail
TM00089

Carcinoma

ER-/PR-/HER2-

Variant data

TM00090

Carcinoma

ER-/PR-/HER2-

Variant data

TM00091

Invasive Ductal Carcinoma

ER-/PR-/HER2-

BRCA1

TM00094

Metaplastic Spindle Cell Carcinoma

ER-/PR-/HER2-

Variant data

TM00095

Invasive Ductal Carcinoma


Variant data

TM00096

Mixed Ductal Carcinoma

ER-/PR-/HER2-; AURKA, NRAS & TP53

Variant data

TM00097

Ductal Carcinoma

ER-/PR-/HER2-; TP53 & KRAS

Variant data

TM00098

Ductal Carcinoma

ER-/PR-/HER2-

Variant data

TM00099

Invasive Ductal Carcinoma

ER-/PR-/HER2-; TP53, ATM, KDR (VEGFR2),

Variant data

TM00103

Ductal Carcinoma

ER-/PR-/HER2+

Variant data

TM00107

Metastatic Adenocarcinoma

ER+/-/PR-/HER2-

TP53

TM00129

Ductal Carcinoma In Situ

ER-/PR-/HER2+

Variant data

TM00284

Metastatic Adenocarcinoma

ER+/PR+/HER2-

Variant data

TM00386

Carcinoma

ER+/PR+/HER2-

Variant data

TM00999

Invasive Ductal Carcinoma

ER-/PR-/HER2-

Variant data

Lung cancer

Our PDX collection has over 50 unique lung cancer PDX models representing a diverse set of clinically relevant mutations currently observed in the clinic. All lung patient-derived lung cancer models are available for efficacy testing at JAX In Vivo Services. For many of our lung PDX tumors, gene expression data and genomic data, standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Lung cancer clinical markers:

  • EGFR activating mutations, such as L858R (TM00784)
  • EGFR L858R mutation with acquired resistance to EGFR inhibitors (TM00199)
  • EGFR T790M mutation that confers resistance to EGFR inhibitors (TM00204)
  • KRAS mutations, associated with resistance to EGFR inhibitors (TM00186 and others)
  • EML4-ALK translocation (TM00206)
Additional lung cancer models are available in the Mouse Tumor Biology Database.

Ovarian cancer

We provide access to a large collection of ovarian PDX models currently available for efficacy testing at our facility or for distribution to your laboratory. For most of our PDX ovarian tumors, gene expression data and genomic data and pathology images are available through the Mouse Tumor Biology Database.

The graph illustrates the response of a papillary serous carcinoma PDX model TM00327 to chemotherapy.

tm00327

Featured ovarian cancer PDX models

Model name Diagnosis Known mutations
TM00324

Ovarian Carcinoma

IDH1; TP53; JAK3; KDR (VEGFR2)

TM00327

Papillary Serous Carcinoma

SMO; PIK3CA

TM00330

Ovarian Carcinoma

Genomic data

TM00332

Serous Carcinoma

TP53

TM00334

Carcinosarcoma, Malignant Mixed Müllerian Tumor 

KRAS; TP53

TM00391

Invasive Mucinous Ovarian Carcinoma

ATM

Additional ovarian cancer models are available in the Mouse Tumor Biology Database.

Pancreatic cancer

We provide access to a large collection of pancreatic cancer PDX models currently available for efficacy testing at our facility or for distribution to your laboratory. For many of our PDX pancreatic tumors, gene expression data and genomic data and pathology images are available through the Mouse Tumor Biology Database.

Featured pancreatic cancer PDX models

Model name  Diagnosis Known mutations
TM00176

Metastatic Pancreatic Carcinoma

 Genomic data

TM00303

Ampullary Cancer

 Genomic data

TM00304

Cholangiocarcinoma

 Genomic data

TM00305

Adenosquamous Carcinoma

 Genomic data

TM00310

Metastatic Pancreatic Carcinoma

KRAS; TP53

TM00312

Invasive Pancreatic Ductal Adenocarcinoma

TP53

TM00314

Pancreatic Carcinoma

KRAS G12A; MPL

TM00319

Pancreatic Carcinoma

TP53; KIT; GNA11


Additional pancreatic cancer models are available in the Mouse Tumor Biology Database.

Search for other PDX tumor types in the Mouse Tumor Biology Database

Over 350 different patient derived xenograft models for cancer research are available from our repository.  Navigate to the Patient Derived Xenograft Model Search page to find unique models based on the primary cancer site, diagnosis, gene variants present in engrafted tumors, gene expression profile, or gene copy number variation.