Humanized Mice Solutions

Access the Full Suite of Humanized Solutions

Our portfolio of humanized mice support the development of functional cellular components of the human immune system. Mouse models with human immune cell engraftment represent ground-breaking platforms to evaluate compounds to treat a variety of human diseases.

  • JAX Solutions

  • Featured Models

JAX Solutions

Humanized CD34+ mice (hu-CD34) are a robust in vivo platform for analyzing the safety and effectiveness of potential new drugs to modulate the immune system. Hu-CD34+ mice are advantageous in vivo models for long-term studies in the fields of human immune cell biology, immuno-oncology, and infectious disease.

Models engrafted with cord blood-derived hematopoietic stem cells (HSC) develop multi-lineage engraftment and display robust T-cell maturation and T-cell dependent inflammatory responses. In addition, an improved human myeloid and NK lineage development is demonstrated in humanized NSG™-SGM3 and NSG™-Tg(IL15) mice. Large cohorts of humanized CD34+ NSG™, NSG™-SGM3 and NSG™-Tg(IL15) mice are available for immediate delivery or to enroll in JAX drug efficacy testing services.

Visit our CD34+ page to learn more.

Featured Models

STRAIN No. SIGNIFICANT MODELING
005557
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
Enhanced engraftment of multiple human tissues
013062
NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ
Enhanced myeloid cell production
030890
NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ
Enhanced Natural Killer Cell production
  • JAX Solutions

  • Featured Models

JAX Solutions

Humanized PBMC (hu-PBMC) mice feature quick engraftment of adult peripheral blood mononuclear cells and enable short-term studies requiring mature human T cells. Hu-PBMC mice are used as in vivo models to study and evaluate compounds for T cell immune modulation, infectious diseases and graft rejection research. Large cohorts of humanized PBMC mice in the background of NSG or NSG MHC I/II Double Knockout are available for immediate delivery or to enroll in JAX drug efficacy testing services.

One of the primary uses of the hu-PBMC-NSG model is the study of acute graft-versus-host disease (GVHD) which is a major problem in clinical hematopoietic stem cell transplantation. NSG mice engrafted with human PBMCs develop an acute xenogeneic GVHD-like disease upon recognition of the murine cells and tissues by mature human T cells. The hu-PBMC-NSG MHC I/II Double Knockout mouse model improves upon the limited brief window available in the hu-PBMC model to conduct experiments before the PBMC engrafted mice become affected by GvHD. NSG mice deficient in murine MHC I/II when engrafted with human PBMCs show delayed development of GvHD and support long-term studies of human immunity requiring human T cell engraftment, human tumor xenograft models, and enable evaluation of immune modulators targeting human T cells.

Visit our PBMC page to learn more.

Featured Models

STRAIN No. SIGNIFICANT MODELING
025216
NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-Ab1em1Mvw H2-D1tm1Bpe Il2rgtm1Wjl/SzJ
Delayed onset of Graft-versus-Host Disease
005557
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
Enhanced engraftment of multiple human tissues

Humanized mice contain human cell populations. Therefore, they are housed in an ABSL2 facility and are handled in a manner consistent with CDC guidelines (BMBL, 6th edition). Proper PPE and handling methods are used at all times when working with these mice.

Humanized Mice Resources