Onco-Hu® Models are a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells to help destroy cancers in vivo.
Humanized NSG™ and NSG™-SGM3 mouse models are powerful tools for studying cancer, inflammatory and infectious disease, and hematopoiesis. We maintain large on-the-shelf inventories of two versatile humanized models. Both are popular models for checkpoint inhibitor development.
NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. This guide explains why the interactions between human immune cells and tumors are paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
Develops immunodeficient mouse models and optimizes technologies for effective human cell and tissue engraftment.
In this webinar, our panel of experts will discuss the successes and caveats of using humanized mouse models to understand disease biology and evaluate therapeutic strategies.
The NOD scid gamma mouse uniquely supports the engraftment of human hematopoietic cells, enabling the creation of “humanized” NSG (huNSG) mice.
Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief guide we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.
Here are 10 reasons to use hu-NSG™ models to test drugs that modulate the human immune system, and also as refined models for infectious diseases.
The monthly NSG™ Mice Pub Alert features recent high impact publications that utilize the NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG™) mouse.
Humanized mouse models, where human tumor tissue is engrafted into immunodeficient NOD SCID gamma (NSG) mice, are frequently used in oncology and infectious disease studies to provide valuable translational insights.
This webinar highlights recent advances and future directions using humanized NSG™ mice with functional human immune cells, to study human infectious diseases including HIV.