Onco-Hu® Models are a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells to help destroy cancers in vivo.
Humanized NSG™ and NSG™-SGM3 mouse models are powerful tools for studying cancer, inflammatory and infectious disease, and hematopoiesis. We maintain large on-the-shelf inventories of two versatile humanized models. Both are popular models for checkpoint inhibitor development.
NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. This guide explains why the interactions between human immune cells and tumors are paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
Investigates human immunological diseases and malignancy through the development and leveraging of novel humanized mouse models
In this webinar, our panel of experts will discuss the successes and caveats of using humanized mouse models to understand disease biology and evaluate therapeutic strategies.
The NOD scid gamma mouse uniquely supports the engraftment of human hematopoietic cells, enabling the creation of “humanized” NSG (huNSG) mice.
NSG™ and NSG™-SGM3 mice engrafted with allogeneic human tumors represent a valuable preclinical testing platform for immuno-oncology. Here we employ four 14-color flow cytometry panels to perform a comprehensive and detailed analysis of the entire immune system. Our results indicate that the triple transgenic NSG™-SGM3 mice exhibit a more completely humanized immune system as compared to NSG™ mice, with specific improvements in the distribution of T-cell subsets and overall representation of the myeloid lineage.
Here are 10 reasons to use hu-NSG™ models to test drugs that modulate the human immune system, and also as refined models for infectious diseases.
The monthly NSG™ Mice Pub Alert features recent high impact publications that utilize the NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG™) mouse.
Humanized mouse models, where human tumor tissue is engrafted into immunodeficient NOD SCID gamma (NSG) mice, are frequently used in oncology and infectious disease studies to provide valuable translational insights.
This webinar highlights recent advances and future directions using humanized NSG™ mice with functional human immune cells, to study human infectious diseases including HIV.