Upcoming Events
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February 7, 2023
JAX™ Tech Talk - Let's Talk About the Uncommon: Rare Diseases
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March 22 – 24, 2023
Workshop on Stereotaxic Surgery in the Laboratory Mouse
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April 29 – May 5, 2023
Workshop on Techniques in Modeling Human Cancer in Mice
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July 17 – 28, 2023
Human and Mammalian Genetics and Genomics: The 64th McKusick Short Course
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August 15 – 22, 2023
32nd Annual Short Course on Experimental Models of Human Cancer
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August 29 – 31, 2023
Workshop on Stereotaxic Surgery in the Laboratory Mouse
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September 11 – 13, 2023
Workshop on Vascular Catheterization in the Laboratory Mouse
Recent Tweets
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RT @emblebi: Explore the newly-launched PDCM Finder @CancerModelsOrg - the largest open catalogue of harmonised patient-derived cancer mode… -
RT @jacksonlab: 📙 New editorial in @FrontiersIn: "Stromal and immune microenvironment in breast cancer metastasis" with Guangwen "Gary" Ren…
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RT @jacksonlab: New in @CellStemCell, @FlorianMerkle @Michael_E_Ward_ @MarkRCookson1 & JAX's @BillSkarnes labs I.D. the KOLF2.1J iPSC line…
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RT @JAX_Education: ⏰ Application deadline: February 15 The two-year mentored program at @jacksonlab supports academically ambitious #postb…
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RT @TheMarkFdn: We’re excited to announce the 2023 Mark Foundation Emerging Leader Awards totaling $4.5 million to six early-career investi…
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RT @jax_mcgi: Join us for our interactive GTB case discussions on Friday, March 31 and Saturday, April 1 during the 2023 MCGI Forum. ✨ Reg…
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RT @TheMarkFdn: Congratulations Jennifer Trowbridge @TrowbridgeLab @JAXcancercenter @jacksonlab t.co/MZ9ryzuewz
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Massive congrats to @JAXcancercenter member @TrowbridgeLab for her 2023 Emerging Leader Award from @TheMarkFdn and thank you to the Mark Foundation for honoring this #exceptionalscientist with your prestigious award! #leukemia #stemcells #aging
News
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1/27 Improving iPSC research with new cell lines
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1/24 Jennifer Trowbridge receives award from The Mark Foundation for Cancer Research
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12/20 Revealing the biology of senescent cells
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12/1 Brooks Scholar Award propels cancer and aging research
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11/22 Understanding cancer-causing MYC and its alternative splicing accomplices
Genes (Basel). 2022 Dec 7; 13(12)
Ontological Analysis of Coronavirus Associated Human Genes at the COVID-19 Disease Portal
Wang SJ, Brodie KC, De Pons JL, Demos WM, Gibson AC, Hayman GT, et al.
The COVID-19 pandemic stemmed a parallel upsurge in the scientific literature about SARS-CoV-2 infection and its health burden. The Rat Genome Database (RGD) created a COVID-19 Disease Portal to leverage information from the scientific literature. In the COVID-19 Portal, gene-disease associations are established by manual curation of…
Hum Mol Genet. 2022 Nov 28; 31(23):4055-4074
Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology
Murray GC, Bais P, Hatton CL, Tadenev ALD, Hoffmann BR, Stodola TJ, et al.
NADK2 encodes the mitochondrial form of nicotinamide adenine dinucleotide (NAD) kinase, which phosphorylates NAD. Rare recessive mutations in human NADK2 are associated with a syndromic neurological mitochondrial disease that includes metabolic changes, such as hyperlysinemia and 2,4 dienoyl CoA reductase (DECR) deficiency. However, the full pathophysiology…
© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.J Surg Oncol. 2023 Mar; 127(3):426-433
Deep learning image analysis quantifies tumor heterogeneity and identifies microsatellite instability in colon cancer
Rubinstein JC, Foroughi Pour A, Zhou J, Sheridan TB, White BS, Chuang JH
Deep learning utilizing convolutional neural networks (CNNs) applied to hematoxylin & eosin (H&E)-stained slides numerically encodes histomorphological tumor features. Tumor heterogeneity is an emerging biomarker in colon cancer that is, captured by these features, whereas microsatellite instability (MSI) is an established biomarker traditionally assessed by immunohistochemistry or polymerase chain reaction.
© 2022 Wiley Periodicals LLC.Genome Biol. 2022 Dec 27; 23(1):270
NetAct: a computational platform to construct core transcription factor regulatory networks using gene activity
Su K, Katebi A, Kohar V, Clauss B, Gordin D, Qin ZS, et al.
A major question in systems biology is how to identify the core gene regulatory circuit that governs the decision-making of a biological process. Here, we develop a computational platform, named NetAct, for constructing core transcription factor regulatory networks using both transcriptomics data and literature-based transcription factor-target databases. NetAct robustly infers regulators' activity using target expression, constructs networks…
© 2022. The Author(s).Nat Rev Genet. 2022 Dec; 23(12):760-771
Extrachromosomal DNA amplifications in cancer
Yi E, Chamorro González R, Henssen AG, Verhaak RGW
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated with worse patient outcome. The functional impact of ecDNA has been linked to its unique properties, such as its circular structure that is associated with altered chromatinization and epigenetic regulatory landscape, as well as its ability to randomly segregate during cell division, which fuels intercellular copy number heterogeneity. Recent investigations suggest that ecDNA is…
© 2022. Springer Nature Limited.Trends Cancer. 2022 Sep; 8(9):747-758
Guilt by association: EcDNA as a mobile transactivator in cancer
Zhu Y, Gong L, Wei CL
Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene amplification and is associated with an aggressive tumor phenotype and poor patient outcome. Despite the long-held knowledge of its existence, little is known about how ecDNA affects tumor cell behavior. Recent data reveal that ecDNA hubs are mobile transcriptional enhancers which can transactivate gene expression through chromatin interactions. Given its prevalence…
Copyright © 2022 Elsevier Inc. All rights reserved.