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November
2021
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Short Course
Hybrid - The Jackson Laboratory, Bar Harbor, ME, & Virtual
Human and Mammalian Genetics and Genomics: The 63rd McKusick Short Course
July
2022
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Short Course
Hybrid - The Jackson Laboratory, Farmington, CT, & Virtual
31st Annual Short Course on Experimental Models of Human Cancer
August
2022
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Workshop
The Jackson Laboratory, Bar Harbor, ME
20th Annual Workshop on the Pathology of Mouse Models for Human Disease
September
2022
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Workshop
The Jackson Laboratory, Bar Harbor, ME
Vascular Catheterization in the Laboratory Mouse
November
2022
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Recent Tweets
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Annual #CancerShortCourse features seminars in #cancer genetics #cellbiology, animal models of human cancers, cancer #immunology & therapy. Workshop-based opportunities including computational, live panel discussions & trainee career development. t.co/3yiGzOtNrE
News
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5/4 Putting machine learning to work for cancer patients
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5/3 JAX announces 2022 recipients of the JAX Scholar awards
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4/27 Researching innate immune cells and metastatic cancer
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4/26 Using machine learning to keep an eye on healthy function and disease
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4/7 New Fellowship at JAX to Unravel the Complexities Between Aging and Cancer
Genetics. 2022 Apr 4; 220(4)
New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
Engel SR, Wong ED, Nash RS, Aleksander S, Alexander M, Douglass E, et al.
Saccharomyces cerevisiae is used to provide fundamental understanding of eukaryotic genetics, gene product function, and cellular biological processes. Saccharomyces Genome Database (SGD) has been supporting the yeast research community since 1993, serving as its de facto hub. Over the years, SGD has maintained the genetic nomenclature, chromosome maps, and functional…
© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.Mamm Genome. 2022 Mar; 33(1):4-18
Mouse Genome Informatics (MGI): latest news from MGD and GXD
Ringwald M, Richardson JE, Baldarelli RM, Blake JA, Kadin JA, Smith C, et al.
The Mouse Genome Informatics (MGI) database system combines multiple expertly curated community data resources into a shared knowledge management ecosystem united by common metadata annotation standards. MGI's mission is to facilitate the use of the mouse as an experimental model for understanding the genetic and genomic basis of human health and disease. MGI is the authoritative source for mouse gene, allele, and strain nomenclature and is the primary source of mouse phenotype annotations…
© 2021. The Author(s).EMBO J. 2022 Dec 17; 41(2):e109445
Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells
Byers C, Spruce C, Fortin HJ, Hartig EI, Czechanski A, Munger SC, et al.
Genetically diverse pluripotent stem cells display varied, heritable responses to differentiation cues. Here, we harnessed these disparities through derivation of mouse embryonic stem cells from the BXD genetic reference panel, along with C57BL/6J (B6) and DBA/2J (D2) parental strains, to identify loci regulating cell state transitions. Upon transition to formative pluripotency, B6 stem cells quickly dissolved naïve networks…
© 2021 The Authors.J Invest Dermatol. 2022 May; 142(5):1260-1264
State of Residency: Microbial Strain Diversity in the Skin
Kong HH, Oh J
Human skin hosts a diversity of microbiota. Advances in sequencing and analytical methods have increasingly illuminated the importance of the finest resolution in understanding the genetic diversity of the skin microbiota, highlighting strain-level differences and their functional implications. Such genetic diversity, which exists within an individual and is strongly individual specific underscores the difficulty in elucidating functionality. Integrated investigations of the microbial strain diversity through sequencing and culture-based approaches…
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.Nat Rev Cancer. 2022 Apr 4
Studying extrachromosomal DNA with the ecTag method
Yi E
View publicationCancer Discov. 2022 Feb; 12(2):468-483
Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer
Yi E, Gujar AD, Guthrie M, Kim H, Zhao D, Johnson KC, et al.
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models and observed how cell-to-cell ecDNA frequency varies greatly. The exceptional intratumoral heterogeneity of ecDNA…
©2021 American Association for Cancer Research.