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2021
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Short Course
The Jackson Laboratory, Bar Harbor, ME
Human and Mammalian Genetics and Genomics: The 63rd McKusick Short Course
July
2022
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Short Course
The Jackson Laboratory, Bar Harbor, ME
31st Annual Short Course on Experimental Models of Human Cancer
August
2022
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Workshop
The Jackson Laboratory, Bar Harbor, ME
20th Annual Workshop on the Pathology of Mouse Models for Human Disease
September
2022
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RT @JAX_Education: High school student? ✔️ Interested in science? ✔️ Join us for @jacksonlab's virtual Open House and cancer genetics work…
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10/14 JAX appoints first ever Chief Medical Officer, Jens Rueter
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10/6 A lifelong friendship inspires support for JAX blood cancer research
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10/5 Discovering how to prevent aging and cancer in the blood cell system
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Cold Spring Harb Mol Case Stud. 2021 Jun; 7(3)
Functional impact of a germline RET mutation in alveolar rhabdomyosarcoma
Berlow NE, Crawford KA, Bult CJ, Noakes C, Sloma I, Rudzinski ER, et al.
Specific mutations in the RET proto-oncogene are associated with multiple endocrine neoplasia type 2A, a hereditary syndrome characterized by tumorigenesis in multiple glandular elements. In rare instances, MEN2A-associated germline RET mutations have also occurred with non-MEN2A associated cancers. One such germline mutant RET mutation occurred concomitantly in a young adult diagnosed with alveolar rhabdomyosarcoma, a pediatric and young adult soft-tissue cancer with a…
© 2021 Berlow et al.; Published by Cold Spring Harbor Laboratory Press.Nat Commun. 2021 Jun 2; 12(1):3297
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Grapotte M, Saraswat M, Bessière C, Menichelli C, Ramilowski JA, Severin J, et al.
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of…
Cancer Cell. 2021 Aug 9; 39(8):1018-1022
Developing and validating model systems for immuno-oncology
McCarthy CE, Zahir N, Eljanne M, Sharon E, Voest EE, Palucka K
Owing to clinical success of immune-checkpoint blockade, immunotherapy is becoming a cornerstone of modern oncology, and immuno-oncology is at the forefront of basic cancer research. This commentary outlines future opportunities for immuno-oncology modeling.
Copyright © 2021 Elsevier Inc. All rights reserved.Nat Commun. 2021 Jul 19; 12(1):4385
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data
Altman MC, Rinchai D, Baldwin N, Toufiq M, Whalen E, Garand M, et al.
As the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract…
© 2021. The Author(s).Nat Genet. 2021 Oct; 53(10):1456-1468
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
Johnson KC, Anderson KJ, Courtois ET, Gujar AD, Barthel FP, Varn FS, et al.
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH mutant or IDH…
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.Neuro Oncol. 2021 May 28
Spatial concordance of DNA methylation classification in diffuse glioma
Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, et al.
Intratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogeneity on classification confidence.
© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.