Oncology
We specialize in the production of innovative oncology research models including PDX models and compound evaluation using PDX or cell line xenograft models, and efficacy testing of cancer immunotherapeutics.
We offer definitive solutions for basic research and therapeutic development to advance the fields of oncology, immunology, and neurobiology. We provide the most robust and innovative humanized pre-clinical models and efficacy testing services to advance your research.
NSG™ and NSG™-SGM3 mice engrafted with allogeneic human tumors represent a valuable preclinical testing platform for immuno-oncology. Here we employ four 14-color flow cytometry panels to perform a comprehensive and detailed analysis of the entire immune system. Our results indicate that the triple transgenic NSG™-SGM3 mice exhibit a more completely humanized immune system as compared to NSG™ mice, with specific improvements in the distribution of T-cell subsets and overall representation of the myeloid lineage.
Humanized NSG™ mice are used by researchers and drug discovery scientists as powerful tools to study hematopoiesis, inflammatory disease and viral host-pathogen interactions. These mouse models are accelerating the development of novel therapies in HIV infection and oncology. This guide describes the development of humanized mice and how to select the appropriate model for your research
This guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development.
We review how JAX inbred mouse strains can be used to model infection as well as treatment and prevention of human infectious diseases.
NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. This guide explains why the interactions between human immune cells and tumors are paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
This guide summarizes the guidelines for preclinical testing and colony management of ALS mice discusses considerations for preclinical studies using SOD1 mice, colony management, QPCR protocol for determining copy number, and more.
Cre-lox technology is a powerful tool for creating sophisticated models of specific human cancers and other human diseases.
This webinar highlights recent advances and future directions using xenografted humanized NSG™ mice with functional human immune cells, to evaluate cancer immunotherapies.