This tool calculates the glomerular filtration rate in mice using the FITC-inulin method
When measuring glomerular filtration rate (GFR) by FITC-Inulin clearance a single bolus of FITC-Inulin is injected intravenously, blood samples are collected at 3, 7, 10, 15, 35, 55, and 75 minutes, and the fluorescent signal is measured. We developed a tool that uses both a one-compartment and two-compartment model to estimate the GFR based on the measurements.
Qi, Z., Whitt, I., Mehta, A., Jin, J., Zhao, M., Harris, R.C., Fogo, A.B., and Breyer, M.D. 2003. Serial Determination of Glomerular Filtration Rate in Conscious Mice Using FITC-Inulin Clearance. Am J Physiol Renal Physiol. 286:F590-F596.
Bivona, B.J., Park, S., Harrison-Bernard, L.M. 2010. Glomerular filtration rate determinations in conscious type II diabetic mice. Am J Physiol Renal Physiol. 300:F618-F625