GFR Calculator

This tool calculates the glomerular filtration rate in mice using the FITC-inulin method

When measuring glomerular filtration rate (GFR) by FITC-Inulin clearance a single bolus of FITC-Inulin is injected intravenously, blood samples are collected at 3, 7, 10, 15, 35, 55, and 75 minutes, and the fluorescent signal is measured. We developed a tool that uses both a one-compartment and two-compartment model to estimate the GFR based on the measurements.

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Qi, Z., Whitt, I., Mehta, A., Jin, J., Zhao, M., Harris, R.C., Fogo, A.B., and Breyer, M.D. 2003. Serial Determination of Glomerular Filtration Rate in Conscious Mice Using FITC-Inulin Clearance. Am J Physiol Renal Physiol. 286:F590-F596.

Bivona, B.J., Park, S., Harrison-Bernard, L.M. 2010. Glomerular filtration rate determinations in conscious type II diabetic mice. Am J Physiol Renal Physiol. 300:F618-F625